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Han, S B; Oh, G T; Kim, Y H; Hong, D H; Hong, N D; Yoo, I D", "year": 1996, "journal": "International journal of immunopharmacology, 18(5), 295-303", "doi": null, "pmid": "8933208", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00021", "slug": "hasler-1997-determination-of-psilocin-and", "title": "Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man.", "authors": "Hasler, F; Bourquin, D; Brenneisen, R; Bär, T; Vollenweider, F X", "year": 1997, "journal": "Pharmaceutica acta Helvetiae, 72(3), 175-84", "doi": null, "pmid": "9204776", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00022", "slug": "walton-1997-bioactivation-of-the-mushroom", "title": "Bioactivation of the mushroom hydrazine, agaritine, to intermediates that bind covalently to proteins and induce mutations in the Ames test.", "authors": "Walton, K; Coombs, M M; Catterall, F S; Walker, R; Ioannides, C", "year": 1997, "journal": "Carcinogenesis, 18(8), 1603-8", "doi": null, "pmid": "9276636", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00023", "slug": "walton-1997-bioactivation-of-mushroom-hydrazines", "title": "Bioactivation of mushroom hydrazines to mutagenic products by mammalian and fungal enzymes.", "authors": "Walton, K; Coombs, M M; Walker, R; Ioannides, C", "year": 1997, "journal": "Mutation research, 381(1), 131-9", "doi": null, "pmid": "9403039", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00024", "slug": "ebina-1998-antitumor-effect-of-a", "title": "Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice.", "authors": "Ebina, T; Fujimiya, Y", "year": 1998, "journal": "Biotherapy (Dordrecht, Netherlands), 11(4), 259-65", "doi": null, "pmid": "9950102", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00025", "slug": "fujimiya-1998-selective-tumoricidal-effect-of", "title": "Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis.", "authors": "Fujimiya, Y; Suzuki, Y; Oshiman, K; Kobori, H; Moriguchi, K; Nakashima, H; Matumoto, Y; Takahara, S; Ebina, T; Katakura, R", "year": 1998, "journal": "Cancer immunology, immunotherapy : CII, 46(3), 147-59", "doi": null, "pmid": "9625538", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00026", "slug": "mizuno-1998-polysaccharides-from-agaricus-blazei", "title": "Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.", "authors": "Mizuno, M; Morimoto, M; Minato, K; Tsuchida, H", "year": 1998, "journal": "Bioscience, biotechnology, and biochemistry, 62(3), 434-7", "doi": null, "pmid": "9571772", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00027", "slug": "wang-1998-effects-of-a-watersoluble", "title": "Effects of a water-soluble extract of Cordyceps sinensis on steroidogenesis and capsular morphology of lipid droplets in cultured rat adrenocortical cells.", "authors": "Wang, S M; Lee, L J; Lin, W W; Chang, C M", "year": 1998, "journal": "Journal of cellular biochemistry, 69(4), 483-9", "doi": null, "pmid": "9620174", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00028", "slug": "yuan-1998-hypoglycemic-effect-of-watersoluble", "title": "Hypoglycemic effect of water-soluble polysaccharide from Auricularia auricula-judae Quel. on genetically diabetic KK-Ay mice.", "authors": "Yuan, Z; He, P; Cui, J; Takeuchi, H", "year": 1998, "journal": "Bioscience, biotechnology, and biochemistry, 62(10), 1898-903", "doi": null, "pmid": "9836425", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00029", "slug": "lin-1999-inhibition-of-activated-human", "title": "Inhibition of activated human mesangial cell proliferation by the natural product of Cordyceps sinensis (H1-A): an implication for treatment of IgA mesangial nephropathy.", "authors": "Lin, C Y; Ku, F M; Kuo, Y C; Chen, C F; Chen, W P; Chen, A; Shiao, M S", "year": 1999, "journal": "The Journal of laboratory and clinical medicine, 133(1), 55-63", "doi": null, "pmid": "10385482", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00030", "slug": "mckay-1999-genetic-and-morphological-characterization", "title": "Genetic and morphological characterization of Cladobotryum species causing cobweb disease of mushrooms.", "authors": "McKay, G J; Egan, D; Morris, E; Scott, C; Brown, A E", "year": 1999, "journal": "Applied and environmental microbiology, 65(2), 606-10", "doi": null, "pmid": "9925589", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00031", "slug": "outila-1999-bioavailability-of-vitamin-d", "title": "Bioavailability of vitamin D from wild edible mushrooms (Cantharellus tubaeformis) as measured with a human bioassay.", "authors": "Outila, T A; Mattila, P H; Piironen, V I; Lamberg-Allardt, C J", "year": 1999, "journal": "The American journal of clinical nutrition, 69(1), 95-8", "doi": null, "pmid": "9925129", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00032", "slug": "falch-2000-the-cytokine-stimulating-activity", "title": "The cytokine stimulating activity of (1-->3)-beta-D-glucans is dependent on the triple helix conformation.", "authors": "Falch, B H; Espevik, T; Ryan, L; Stokke, B T", "year": 2000, "journal": "Carbohydrate research, 329(3), 587-96", "doi": null, "pmid": "11128587", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00033", "slug": "walton-2000-fate-of-the-mushroom", "title": "Fate of the mushroom hydrazine agaritine in the rat and mouse.", "authors": "Walton, K; Coombs, M M; King, L J; Walker, R; Ioannides, C", "year": 2000, "journal": "Nutrition and cancer, 37(1), 55-64", "doi": null, "pmid": "10965520", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00034", "slug": "grube-2001-white-button-mushroom-phytochemicals", "title": "White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.", "authors": "Grube, B J; Eng, E T; Kao, Y C; Kwon, A; Chen, S", "year": 2001, "journal": "The Journal of nutrition, 131(12), 3288-93", "doi": null, "pmid": "11739882", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00035", "slug": "horio-2001-maitake-grifola-frondosa-improve", "title": "Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats.", "authors": "Horio, H; Ohtsuru, M", "year": 2001, "journal": "Journal of nutritional science and vitaminology, 47(1), 57-63", "doi": null, "pmid": "11349892", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00036", "slug": "huang-2001-cordyceps-sinensis-and-its", "title": "Cordyceps sinensis and its fractions stimulate MA-10 mouse Leydig tumor cell steroidogenesis.", "authors": "Huang, B M; Ju, S Y; Wu, C S; Chuang, W J; Sheu, C C; Leu, S F", "year": 2001, "journal": "Journal of andrology, 22(5), 831-7", "doi": null, "pmid": "11545297", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00037", "slug": "huang-2001-effects-of-cordyceps-sinensis", "title": "Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells.", "authors": "Huang, B M; Hsu, C C; Tsai, S J; Sheu, C C; Leu, S F", "year": 2001, "journal": "Life sciences, 69(22), 2593-602", "doi": null, "pmid": "11712663", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00038", "slug": "ohno-2001-antitumor-beta-glucan-from", "title": "Antitumor beta glucan from the cultured fruit body of Agaricus blazei.", "authors": "Ohno, N; Furukawa, M; Miura, N N; Adachi, Y; Motoi, M; Yadomae, T", "year": 2001, "journal": "Biological & pharmaceutical bulletin, 24(7), 820-8", "doi": null, "pmid": "11456124", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00039", "slug": "takaku-2001-isolation-of-an-antitumor", "title": "Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action.", "authors": "Takaku, T; Kimura, Y; Okuda, H", "year": 2001, "journal": "The Journal of nutrition, 131(5), 1409-13", "doi": null, "pmid": "11340091", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00040", "slug": "walton-2001-the-metabolism-and-bioactivation", "title": "The metabolism and bioactivation of agaritine and of other mushroom hydrazines by whole mushroom homogenate and by mushroom tyrosinase.", "authors": "Walton, K; Coombs, M M; Walker, R; Ioannides, C", "year": 2001, "journal": "Toxicology, 161(3), 165-77", "doi": null, "pmid": "11297805", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00041", "slug": "balon-2002-a-fermentation-product-of", "title": "A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats.", "authors": "Balon, Thomas W; Jasman, Arnie P; Zhu, Jia-Shi", "year": 2002, "journal": "Journal of alternative and complementary medicine (New York, N.Y.), 8(3), 315-23", "doi": null, "pmid": "12165189", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00042", "slug": "barbisan-2002-influence-of-aqueous-extract", "title": "Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine.", "authors": "Barbisan, L F; Miyamoto, M; Scolastici, C; Salvadori, D M F; Ribeiro, L R; Eira, A F; de Camargo, João Lauro Viana", "year": 2002, "journal": "Journal of ethnopharmacology, 83(1-2), 25-32", "doi": null, "pmid": "12413704", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00043", "slug": "dauby-2002-crossreactivity-between-raw-mushroom", "title": "Cross-reactivity between raw mushroom and molds in a patient with oral allergy syndrome.", "authors": "Dauby, Pierr-Alain L; Whisman, Bonnie A; Hagan, Larry", "year": 2002, "journal": "Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 89(3), 319-21", "doi": null, "pmid": "12269655", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00044", "slug": "dong-2002-structural-characterization-of-a", "title": "Structural characterization of a water-soluble beta-D-glucan from fruiting bodies of Agaricus blazei Murr.", "authors": "Dong, Qun; Yao, Jian; Yang, Xiao-tong; Fang, Ji-nian", "year": 2002, "journal": "Carbohydrate research, 337(15), 1417-21", "doi": null, "pmid": "12204626", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00045", "slug": "hajslova-2002-stability-of-agaritine-a", "title": "Stability of agaritine - a natural toxicant of Agaricus mushrooms.", "authors": "Hajslová, J; Hájková, L; Schulzová, V; Frandsen, H; Gry, J; Andersson, H C", "year": 2002, "journal": "Food additives and contaminants, 19(11), 1028-33", "doi": null, "pmid": "12456273", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00046", "slug": "hajslova-2002-stability-of-agaritine-a-2", "title": "Stability of agaritine - a natural toxicant of Agaricus mushrooms.", "authors": "Hajslová, J; Hájková, L; Schulzová, V; Frandsen, H; Gry, J; Andersson, H C", "year": 2002, "journal": "Food additives and contaminants, 19(11), 1028-33", "doi": null, "pmid": "12456273", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00047", "slug": "hashimoto-2002-suppressive-effect-of-polysaccharides", "title": "Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice.", "authors": "Hashimoto, Takashi; 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Shen, Wei", "year": 2003, "journal": "World journal of gastroenterology, 9(3), 529-33", "doi": null, "pmid": "12632512", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00061", "slug": "pinheiro-2003-chemoprevention-of-preneoplastic-liver", "title": "Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat.", "authors": "Pinheiro, F; Faria, R R; de Camargo, J L V; Spinardi-Barbisan, A L T; da Eira, A F; Barbisan, L F", "year": 2003, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 41(11), 1543-50", "doi": null, "pmid": "12963007", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00062", "slug": "song-2003-protective-effects-of-fermented", "title": "Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.", "authors": "Song, Tuzz-Ying; Yen, Gow-Chin", "year": 2003, "journal": "Journal of agricultural and food chemistry, 51(6), 1571-7", "doi": null, "pmid": "12617586", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00063", "slug": "tateno-2003-molecular-cloning-expression-and", "title": "Molecular cloning, expression, and characterization of novel hemolytic lectins from the mushroom Laetiporus sulphureus, which show homology to bacterial toxins.", "authors": "Tateno, Hiroaki; Goldstein, Irwin J", "year": 2003, "journal": "The Journal of biological chemistry, 278(42), 40455-63", "doi": null, "pmid": "12900403", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00064", "slug": "wang-2003-the-vasorelaxation-of-antrodia", "title": "The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway.", "authors": "Wang, Guei-Jane; Tseng, Hsiang-Wen; Chou, Cheng-Jen; Tsai, Tung-Hu; Chen, Chi-Tin; Lu, Mei-Kuang", "year": 2003, "journal": "Life sciences, 73(21), 2769-83", "doi": null, "pmid": "13679244", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00065", "slug": "han-1999-the-inhibitory-effect-of", "title": "The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis.", "authors": "Han, S B; Lee, C W; Jeon, Y J; Hong, N D; Yoo, I D; Yang, K H; Kim, H M", "year": 1999, "journal": "Immunopharmacology, 41(2), 157-64", "doi": null, "pmid": "10102797", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00066", "slug": "ahn-2004-natural-killer-cell-activity", "title": "Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.", "authors": "Ahn, W-S; Kim, D-J; Chae, G-T; Lee, J-M; Bae, S-M; Sin, J-I; Kim, Y-W; Namkoong, S-E; Lee, I P", "year": 2004, "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 14(4), 589-94", "doi": null, "pmid": "15304151", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00067", "slug": "cao-2004-antitumor-and-antiangiogenic-activity", "title": "Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide.", "authors": "Cao, Qi-Zhen; Lin, Zhi-Bin", "year": 2004, "journal": "Acta pharmacologica Sinica, 25(6), 833-8", "doi": null, "pmid": "15169641", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00068", "slug": "chen-2004-coimmunization-of-agaricus-blazei", "title": "Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses.", "authors": "Chen, L; Shao, H J; Su, Y B", "year": 2004, "journal": "International immunopharmacology, 4(3), 403-9", "doi": null, "pmid": "15037217", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00069", "slug": "huang-2004-upregulation-of-steroidogenic-enzymes", "title": "Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium.", "authors": "Huang, Bu-Miin; Hsiao, Kuei-Yang; Chuang, Pei-Chin; Wu, Meng-Hsing; Pan, Hsien-An; Tsai, Shaw-Jenq", "year": 2004, "journal": "Biology of reproduction, 70(5), 1358-64", "doi": null, "pmid": "14711788", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00070", "slug": "huang-2004-in-vivo-stimulatory-effect", "title": "In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse.", "authors": "Huang, Yuan-Li; Leu, Sew-Fen; Liu, Bi-Ching; Sheu, Chia-Chin; Huang, Bu-Miin", "year": 2004, "journal": "Life sciences, 75(9), 1051-62", "doi": null, "pmid": "15207653", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00071", "slug": "kasai-2004-il12-production-induced-by", "title": "IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR).", "authors": "Kasai, H; He, L M; Kawamura, M; Yang, P T; Deng, X W; Munkanta, M; Yamashita, A; Terunuma, H; Hirama, M; Horiuchi, I; Natori, T; Koga, T; Amano, Y; Yamaguchi, N; Ito, M", "year": 2004, "journal": "Evidence-based complementary and alternative medicine : eCAM, 1(3), 259-267", "doi": null, "pmid": "15841259", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00072", "slug": "kim-2004-acidic-polysaccharide-isolated-from", "title": "Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages.", "authors": "Kim, Gi-Young; Choi, Gap-Seong; Lee, Sang-Hee; Park, Yeong-Min", "year": 2004, "journal": "Journal of ethnopharmacology, 95(1), 69-76", "doi": null, "pmid": "15374609", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00073", "slug": "kimura-2004-isolation-of-an-antiangiogenic", "title": "Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.", "authors": "Kimura, Yoshiyuki; Kido, Tadashi; Takaku, Takeshi; Sumiyoshi, Maho; Baba, Kimiye", "year": 2004, "journal": "Cancer science, 95(9), 758-64", "doi": null, "pmid": "15471563", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00074", "slug": "liu-2004-antitumor-effects-of-the", "title": "Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action.", "authors": "Liu, Jun-Jen; Huang, Tien-Shang; Hsu, Ming-Ling; Chen, Chin-Chu; Lin, Wen-Shin; Lu, Fung-Jou; Chang, Wen-Huei", "year": 2004, "journal": "Toxicology and applied pharmacology, 201(2), 186-93", "doi": null, "pmid": "15541758", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00075", "slug": "parcell-2004-cordyceps-sinensis-cordymax-cs4", "title": "Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance.", "authors": "Parcell, Allen C; Smith, Jason M; Schulthies, Shane S; Myrer, J William; Fellingham, Gilbert", "year": 2004, "journal": "International journal of sport nutrition and exercise metabolism, 14(2), 236-42", "doi": null, "pmid": "15118196", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00076", "slug": "park-2004-chaga-mushroom-extract-inhibits", "title": "Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.", "authors": "Park, Yoo Kyoung; Lee, Hyang Burm; Jeon, Eun-Jae; Jung, Hack Sung; Kang, Myung-Hee", "year": 2004, "journal": "BioFactors (Oxford, England), 21(1-4), 109-12", "doi": null, "pmid": "15630179", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00077", "slug": "shen-2004-evaluation-of-the-antiinflammatory", "title": "Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata.", "authors": "Shen, Yuh-Chiang; Wang, Yea-Hwey; Chou, Yueh-Ching; Chen, Chieh-Fu; Lin, Lie-Chwen; Chang, Tun-Tschu; Tien, Jung-Hsiung; Chou, Cheng-Jen", "year": 2004, "journal": "Planta medica, 70(4), 310-4", "doi": null, "pmid": "15095145", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00078", "slug": "bernardshaw-2005-an-extract-of-the", "title": "An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro.", "authors": "Bernardshaw, Soosaipillai; Hetland, Geir; Ellertsen, Linda Kathrine; Tryggestad, Anne Merete Aaland; Johnson, Egil", "year": 2005, "journal": "Inflammation, 29(4-6), 147-53", "doi": null, "pmid": "17091395", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00079", "slug": "hseu-2005-antiinflammatory-potential-of-antrodia", "title": "Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway.", "authors": "Hseu, You-Cheng; Wu, Fang-Yang; Wu, Jia-Jiuan; Chen, Jing-Yi; Chang, Wen-Huei; Lu, Fung-Jou; Lai, Yu-Ching; Yang, Hsin-Ling", "year": 2005, "journal": "International immunopharmacology, 5(13-14), 1914-25", "doi": null, "pmid": "16275626", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00080", "slug": "hsu-2005-apoptotic-effects-of-extract", "title": "Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.", "authors": "Hsu, Ya-Ling; Kuo, Yu-Chun; Kuo, Po-Lin; Ng, Lean-Teik; Kuo, Yueh-Hsiung; Lin, Chun-Ching", "year": 2005, "journal": "Cancer letters, 221(1), 77-89", "doi": null, "pmid": "15797630", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00081", "slug": "kerrigan-2005-agaricus-subrufescens-a-cultivated", "title": "Agaricus subrufescens, a cultivated edible and medicinal mushroom, and its synonyms.", "authors": "Kerrigan, Richard W", "year": 2005, "journal": "Mycologia, 97(1), 12-24", "doi": null, "pmid": "16389952", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00082", "slug": "kim-2005-antidiabetic-activity-of-betaglucans", "title": "Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei.", "authors": "Kim, Yea-Woon; Kim, Ki-Hoon; Choi, Hyun-Ju; Lee, Dong-Seok", "year": 2005, "journal": "Biotechnology letters, 27(7), 483-7", "doi": null, "pmid": "15928854", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00083", "slug": "kuroiwa-2005-lack-of-subchronic-toxicity", "title": "Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats.", "authors": "Kuroiwa, Y; Nishikawa, A; Imazawa, T; Kanki, K; Kitamura, Y; Umemura, T; Hirose, M", "year": 2005, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 43(7), 1047-53", "doi": null, "pmid": "15833380", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00084", "slug": "lin-2005-cellular-and-molecular-mechanisms", "title": "Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum.", "authors": "Lin, Zhi-Bin", "year": 2005, "journal": "Journal of pharmacological sciences, 99(2), 144-53", "doi": null, "pmid": "16230843", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00085", "slug": "rehner-2005-a-beauveria-phylogeny-inferred", "title": "A Beauveria phylogeny inferred from nuclear ITS and EF1-alpha sequences: evidence for cryptic diversification and links to Cordyceps teleomorphs.", "authors": "Rehner, Stephen A; Buckley, Ellen", "year": 2005, "journal": "Mycologia, 97(1), 84-98", "doi": null, "pmid": "16389960", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00086", "slug": "song-2005-mycelia-from-antrodia-camphorata", "title": "Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.", "authors": "Song, Tuzz-Ying; Hsu, Shih-Lan; Yeh, Chi-Tai; Yen, Gow-Chin", "year": 2005, "journal": "Journal of agricultural and food chemistry, 53(14), 5559-64", "doi": null, "pmid": "15998114", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00087", "slug": "stanley-2005-ganoderma-lucidum-suppresses-angiogenesis", "title": "Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells.", "authors": "Stanley, Gwenaelle; Harvey, Kevin; Slivova, Veronika; Jiang, Jiahua; Sliva, Daniel", "year": 2005, "journal": "Biochemical and biophysical research communications, 330(1), 46-52", "doi": null, "pmid": "15781230", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00088", "slug": "tang-2005-a-randomized-doubleblind-and", "title": "A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia.", "authors": "Tang, Wenbo; Gao, Yihuai; Chen, Guoliang; Gao, He; Dai, Xihu; Ye, Jinxian; Chan, Eli; Huang, Min; Zhou, Shufeng", "year": 2005, "journal": "Journal of medicinal food, 8(1), 53-8", "doi": null, "pmid": "15857210", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00089", "slug": "zhong-2005-in-vitro-augmentation-of", "title": "In vitro augmentation of natural killer activity and interferon-gamma production in murine spleen cells with Agaricus blazei fruiting body fractions.", "authors": "Zhong, Ming; Tai, Akihiro; Yamamoto, Itaru", "year": 2005, "journal": "Bioscience, biotechnology, and biochemistry, 69(12), 2466-9", "doi": null, "pmid": "16377912", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00090", "slug": "adie-2006-temporal-and-spatial-dispersal", "title": "Temporal and spatial dispersal of cladobotryum conidia in the controlled environment of a mushroom growing room.", "authors": "Adie, Bruce; Grogan, Helen; Archer, Simon; 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Watanabe, Asako; Iwanaga, Yuko; Abe, Ikuro; Tanaka, Hideya; Nagaoka, Megumi Hamano; Akiyama, Hiroshi; Maitani, Tamio", "year": 2006, "journal": "Journal of chromatography. 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Pan, Ching-Liang; Yao, Yun-Chin; Chang, Shau-Shin; Li, Shun-Lai; Wu, Ting-Feng", "year": 2006, "journal": "Proteomics, 6(3), 826-35", "doi": null, "pmid": "16411266", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00109", "slug": "yang-2006-antrodia-camphorata-in-submerged", "title": "Antrodia camphorata in submerged culture protects low density lipoproteins against oxidative modification.", "authors": "Yang, Hsin-Ling; Hseu, You-Cheng; Chen, Jing-Yi; Yech, Yi-Jen; Lu, Fung-Jou; Wang, Hsuan-Hui; Lin, Perng-Shiang; Wang, Bor-Cheh", "year": 2006, "journal": "The American journal of Chinese medicine, 34(2), 217-31", "doi": null, "pmid": "16552834", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00110", "slug": "akramiene-2007-effects-of-betaglucans-on", "title": "Effects of beta-glucans on the immune system.", "authors": "Akramiene, Dalia; Kondrotas, Anatolijus; Didziapetriene, Janina; Kevelaitis, Egidijus", "year": 2007, "journal": "Medicina (Kaunas, Lithuania), 43(8), 597-606", "doi": null, "pmid": "17895634", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00111", "slug": "brown-2007-structure-of-the-fungal", "title": "Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.", "authors": "Brown, James; O'Callaghan, Chris A; Marshall, Andrew S J; Gilbert, Robert J C; Siebold, Christian; Gordon, Siamon; Brown, Gordon D; Jones, E Yvonne", "year": 2007, "journal": "Protein science : a publication of the Protein Society, 16(6), 1042-52", "doi": null, "pmid": "17473009", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00112", "slug": "faccin-2007-antiviral-activity-of-aqueous", "title": "Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1.", "authors": "Faccin, L C; Benati, F; Rincão, V P; Mantovani, M S; Soares, S A; Gonzaga, M L; Nozawa, C; Carvalho Linhares, R E", "year": 2007, "journal": "Letters in applied microbiology, 45(1), 24-8", "doi": null, "pmid": "17594456", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00113", "slug": "hong-2007-antidiabetic-effect-of-an", "title": "Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.", "authors": "Hong, Lei; Xun, Ma; Wutong, Wu", "year": 2007, "journal": "The Journal of pharmacy and pharmacology, 59(4), 575-82", "doi": null, "pmid": "17430642", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00114", "slug": "hsu-2007-the-mushroom-agaricus-blazei", "title": "The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.", "authors": "Hsu, Chung-Hua; Liao, Yang-Li; Lin, Su-Ching; Hwang, Kung-Chang; Chou, Pesus", "year": 2007, "journal": "Journal of alternative and complementary medicine (New York, N.Y.), 13(1), 97-102", "doi": null, "pmid": "17309383", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00115", "slug": "khatun-2007-oyster-mushroom-reduced-blood", "title": "Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects.", "authors": "Khatun, K; Mahtab, H; Khanam, P A; Sayeed, M A; Khan, K A", "year": 2007, "journal": "Mymensingh medical journal : MMJ, 16(1), 94-9", "doi": null, "pmid": "17344789", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00116", "slug": "kim-2007-phellinus-linteus-inhibits-inflammatory", "title": "Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage.", "authors": "Kim, Ho Gyoung; Yoon, Deok Hyo; Lee, Won Ho; Han, Sang Kuk; Shrestha, Bhushan; Kim, Chun Hoi; Lim, Mi Hee; Chang, Woochul; Lim, Soyeon; Choi, Sunga; Song, Won O; Sung, Jae Mo; Hwang, Ki Chul; Kim, Tae Woong", "year": 2007, "journal": "Journal of ethnopharmacology, 114(3), 307-15", "doi": null, "pmid": "17936530", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00117", "slug": "kim-2007-ethanol-extract-of-inonotus", "title": "Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.", "authors": "Kim, Ho-Gyoung; Yoon, Deok-Hyo; Kim, Chun-Hoi; Shrestha, Bhushan; Chang, Woo-Chul; Lim, So-Yeon; Lee, Won-Ho; Han, Sang-Guk; Lee, Je-O; Lim, Mi-Hee; Kim, Geun-Young; Choi, Sunga; Song, Won O; Sung, Jae-Mo; Hwang, Ki-Chul; Kim, Tae-Woong", "year": 2007, "journal": "Journal of medicinal food, 10(1), 80-9", "doi": null, "pmid": "17472471", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00118", "slug": "lee-2007-new-antioxidant-polyphenols-from", "title": "New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.", "authors": "Lee, In-Kyoung; Kim, Young-Sook; Jang, Yoon-Woo; Jung, Jin-Young; Yun, Bong-Sik", "year": 2007, "journal": "Bioorganic & medicinal chemistry letters, 17(24), 6678-81", "doi": null, "pmid": "17980585", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00119", "slug": "liu-2007-comparative-antiinflammatory-characterization-of", "title": "Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action.", "authors": "Liu, Der-Zen; Liang, Hong-Jen; Chen, Chien-Ho; Su, Ching-Hua; Lee, Tzong-Huei; Huang, Chun-Ting; Hou, Wen-Chi; Lin, Shyr-Yi; Zhong, Wen-Bin; Lin, Pei-Jung; Hung, Ling-Fang; Liang, Yu-Chih", "year": 2007, "journal": "Journal of ethnopharmacology, 113(1), 45-53", "doi": null, "pmid": "17590297", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00120", "slug": "lu-2007-protective-effects-of-mycelia", "title": "Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.", "authors": "Lu, Zhen-Ming; Tao, Wen-Yi; Zou, Xi-Liang; Fu, Hui-Zi; Ao, Zong-Hua", "year": 2007, "journal": "Journal of ethnopharmacology, 110(1), 160-4", "doi": null, "pmid": "17092673", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00121", "slug": "talcott-2007-measuring-perceived-effects-of", "title": "Measuring perceived effects of drinking an extract of basidiomycetes Agaricus blazei Murill: a survey of Japanese consumers with cancer.", "authors": "Talcott, James A; Clark, Jack A; Lee, Insu P", "year": 2007, "journal": "BMC complementary and alternative medicine, 7, 32", "doi": null, "pmid": "17967191", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00122", "slug": "wanmuang-2007-fatal-fulminant-hepatitis-associated", "title": "Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder.", "authors": "Wanmuang, Harirak; Leopairut, Juvady; Kositchaiwat, Chomsri; Wananukul, Winai; Bunyaratvej, Sukhum", "year": 2007, "journal": "Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 90(1), 179-81", "doi": null, "pmid": "17621752", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00123", "slug": "wicks-2007-safety-and-tolerability-of", "title": "Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial.", "authors": "Wicks, Sheila M; Tong, Robin; Wang, Chong-Zhi; O'Connor, Michael; Karrison, Theodore; Li, Shang; Moss, Jonathan; Yuan, Chun-Su", "year": 2007, "journal": "The American journal of Chinese medicine, 35(3), 407-14", "doi": null, "pmid": "17597499", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00124", "slug": "wu-2007-modulation-of-inflammationrelated-genes", "title": "Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata.", "authors": "Wu, Yen-ying; Chen, Chin-chu; Chyau, Charng-cherng; Chung, Sin-yi; Liu, Yi-wen", "year": 2007, "journal": "Acta pharmacologica Sinica, 28(2), 258-67", "doi": null, "pmid": "17241529", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00125", "slug": "yuminamochi-2007-interleukin12-and-interferongammamediated-natural", "title": "Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.", "authors": "Yuminamochi, Eri; Koike, Taisuke; Takeda, Kazuyoshi; Horiuchi, Isao; Okumura, Ko", "year": 2007, "journal": "Immunology, 121(2), 197-206", "doi": null, "pmid": "17346284", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00126", "slug": "barros-2008-chemical-composition-and-biological", "title": "Chemical composition and biological properties of portuguese wild mushrooms: a comprehensive study.", "authors": "Barros, Lillian; Venturini, Bruna A; Baptista, Paula; Estevinho, Letícia M; Ferreira, Isabel C F R", "year": 2008, "journal": "Journal of agricultural and food chemistry, 56(10), 3856-62", "doi": "10.1021/jf8003114", "pmid": "18435539", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00127", "slug": "chang-2008-effect-of-cordyceps-militaris", "title": "Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats.", "authors": "Chang, Ying; Jeng, Kee-Ching; Huang, Kuei-Fen; Lee, Ying-Chung; Hou, Chien-Wei; Chen, Kuan-Hao; Cheng, Fu-Yen; Liao, Jiunn-Wang; Chen, Yuh-Shuen", "year": 2008, "journal": "The American journal of Chinese medicine, 36(5), 849-59", "doi": null, "pmid": "19051352", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00128", "slug": "chen-2008-effect-of-polysaccharide-from", "title": "Effect of polysaccharide from Auricularia auricula on blood lipid metabolism and lipoprotein lipase activity of ICR mice fed a cholesterol-enriched diet.", "authors": "Chen, G; Luo, Y C; Li, B P; Li, B; Guo, Y; Li, Y; Su, W; Xiao, Z L", "year": 2008, "journal": "Journal of food science, 73(6), H103-8", "doi": null, "pmid": "19241585", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00129", "slug": "chen-2008-polysaccharides-from-antrodia-camphorata", "title": "Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.", "authors": "Chen, Yu-Jen; 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Ho, Chin-Man; Lin, Ko-Long; Tsai, Jeng-Yu; Jan, Chung-Ren", "year": 2009, "journal": "The Chinese journal of physiology, 52(3), 128-35", "doi": null, "pmid": "19777798", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00156", "slug": "ji-2009-antiaging-effect-of-cordyceps", "title": "Antiaging effect of Cordyceps sinensis extract.", "authors": "Ji, Deng-Bo; Ye, Jia; Li, Chang-Ling; Wang, Yu-Hua; Zhao, Jiong; Cai, Shao-Qing", "year": 2009, "journal": "Phytotherapy research : PTR, 23(1), 116-22", "doi": "10.1002/ptr.2576", "pmid": "18803231", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00157", "slug": "johnson-2009-effect-of-an-extract", "title": "Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo.", "authors": "Johnson, E; Førland, D T; Saetre, L; Bernardshaw, S V; Lyberg, T; Hetland, G", "year": 2009, "journal": "Scandinavian journal of immunology, 69(3), 242-50", "doi": "10.1111/j.1365-3083.2008.02218.x", "pmid": "19281536", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00158", "slug": "kho-2009-antioxidant-capacity-of-fresh", "title": "Antioxidant capacity of fresh and processed fruit bodies and mycelium of Auricularia auricula-judae (Fr.) Quél.", "authors": "Kho, Y S; Vikineswary, S; Abdullah, Noorlidah; Kuppusamy, U R; Oh, H I", "year": 2009, "journal": "Journal of medicinal food, 12(1), 167-74", "doi": "10.1089/jmf.2007.0568", "pmid": "19298211", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00159", "slug": "koyyalamudi-2009-vitamin-d2-formation-and", "title": "Vitamin D2 formation and bioavailability from Agaricus bisporus button mushrooms treated with ultraviolet irradiation.", "authors": "Koyyalamudi, Sundar Rao; Jeong, Sang-Chul; Song, Chi-Hyun; Cho, Kai Yip; Pang, Gerald", "year": 2009, "journal": "Journal of agricultural and food chemistry, 57(8), 3351-5", "doi": "10.1021/jf803908q", "pmid": "19281276", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00160", "slug": "lee-2009-cordycepin-inhibits-uvbinduced-matrix", "title": "Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts.", "authors": "Lee, Young Rae; Noh, Eun Mi; Jeong, Eun Yong; Yun, Seok Kweon; Jeong, Young Ju; Kim, Jong Hyeon; Kwon, Kang Beom; Kim, Byeong Soo; Lee, Sung Ho; Park, Chang Sik; Kim, Jong Suk", "year": 2009, "journal": "Experimental & molecular medicine, 41(8), 548-54", "doi": "10.3858/emm.2009.41.8.060", "pmid": "19381070", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00161", "slug": "li-2009-clinical-application-of-cordyceps", "title": "Clinical application of Cordyceps sinensis on immunosuppressive therapy in renal transplantation.", "authors": "Li, Y; Xue, W-J; Tian, P-X; Ding, X-M; Yan, H; Pan, X-M; Feng, X-S", "year": 2009, "journal": "Transplantation proceedings, 41(5), 1565-9", "doi": "10.1016/j.transproceed.2009.02.085", "pmid": "19545680", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00162", "slug": "li-2009-a-novel-inhibitory-effect", "title": "A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice.", "authors": "Li, Yi-Heng; Chung, Hsing-Chun; Liu, Shu-Lin; Chao, Ting-Hsing; Chen, Jian-Chyi", "year": 2009, "journal": "International heart journal, 50(2), 207-20", "doi": null, "pmid": "19367031", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00163", "slug": "lu-2009-active-extracts-of-wild", "title": "Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A.", "authors": "Lu, Mei-Chin; Du, Ying-Chi; Chuu, Jiunn-Jye; Hwang, Shiuh-Lin; Hsieh, Pao-Chuan; Hung, Chih-Sheng; Chang, Fang-Rong; Wu, Yang-Chang", "year": 2009, "journal": "Archives of toxicology, 83(2), 121-9", "doi": "10.1007/s00204-008-0337-3", "pmid": "18709356", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00164", "slug": "lv-2009-comparison-of-hypoglycemic-activity", "title": "Comparison of hypoglycemic activity of trace elements absorbed in fermented mushroom of Coprinus comatus.", "authors": "Lv, Yingtao; Han, Linna; Yuan, Chao; Guo, Jianyou", "year": 2009, "journal": "Biological trace element research, 131(2), 177-85", "doi": "10.1007/s12011-009-8352-7", "pmid": "19283342", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00165", "slug": "mori-2009-improving-effects-of-the", "title": "Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.", "authors": "Mori, Koichiro; Inatomi, Satoshi; Ouchi, Kenzi; Azumi, Yoshihito; Tuchida, Takashi", "year": 2009, "journal": "Phytotherapy research : PTR, 23(3), 367-72", "doi": "10.1002/ptr.2634", "pmid": "18844328", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00166", "slug": "niu-2009-a-low-molecular-weight", "title": "A low molecular weight polysaccharide isolated from Agaricus blazei Murill (LMPAB) exhibits its anti-metastatic effect by down-regulating metalloproteinase-9 and up-regulating Nm23-H1.", "authors": "Niu, Ying-Cai; Liu, Ji-Cheng; Zhao, Xue-Mei; Cao, Jun", "year": 2009, "journal": "The American journal of Chinese medicine, 37(5), 909-21", "doi": null, "pmid": "19885951", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00167", "slug": "noh-2009-cordycepin-inhibits-il1betainduced-mmp1", "title": "Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.", "authors": "Noh, E-M; Kim, J-S; Hur, H; Park, B-H; Song, E-K; Han, M-K; Kwon, K-B; Yoo, W-H; Shim, I-K; Lee, S J; Youn, H J; Lee, Y-R", "year": 2009, "journal": "Rheumatology (Oxford, England), 48(1), 45-8", "doi": "10.1093/rheumatology/ken417", "pmid": "19056796", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00168", "slug": "panossian-2009-evidencebased-efficacy-of-adaptogens", "title": "Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.", "authors": "Panossian, Alexander; 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Huang, Jian; Xie, Xing; Holman, C D'Arcy J", "year": 2009, "journal": "International journal of cancer, 124(6), 1404-8", "doi": "10.1002/ijc.24047", "pmid": "19048616", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00174", "slug": "ziliotto-2009-screening-for-in-vitro", "title": "Screening for in vitro and in vivo antitumor activities of the mushroom Agaricus blazei.", "authors": "Ziliotto, Liane; Pinheiro, Fabriciano; Barbisan, Luís Fernando; Rodrigues, Maria Aparecida Marchesan", "year": 2009, "journal": "Nutrition and cancer, 61(2), 245-50", "doi": "10.1080/01635580802395717", "pmid": "19235041", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00175", "slug": "chen-2010-structure-and-functions-of", "title": "Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.", "authors": "Chen, Chia-Jung; Vijaya Krishna, R; Tsai, Chia-Che; Wu, Wan-Hsun; Chao, Louis Kuoping; 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Johnson, E; Tryggestad, A M A; Lyberg, T; Hetland, G", "year": 2010, "journal": "Cytokine, 49(3), 245-50", "doi": "10.1016/j.cyto.2009.09.002", "pmid": "20036142", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00182", "slug": "hseu-2010-antrodia-camphorata-suppresses-lipopolysaccharideinduced", "title": "Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging.", "authors": "Hseu, You-Cheng; Huang, Hui-Chi; Hsiang, Chien-Yun", "year": 2010, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(8-9), 2319-25", "doi": "10.1016/j.fct.2010.05.066", "pmid": "20621584", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00183", "slug": "hsieh-2010-methyl-antcinate-a-from", "title": "Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.", "authors": "Hsieh, Yun-Chih; Rao, Yerra Koteswara; Wu, Chun-Chi; Huang, Chi-Ying F; Geethangili, Madamanchi; Hsu, Shih-Lan; Tzeng, Yew-Min", "year": 2010, "journal": "Chemical research in toxicology, 23(7), 1256-67", "doi": "10.1021/tx100116a", "pmid": "20557081", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00184", "slug": "huang-2010-fruiting-body-of-niuchangchih", "title": "Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.", "authors": "Huang, Chia-Hsin; Chang, Yuan-Yen; Liu, Cheng-Wei; Kang, Wen-Yu; Lin, Yi-Ling; Chang, Hsien-Chang; Chen, Yi-Chen", "year": 2010, "journal": "Journal of agricultural and food chemistry, 58(6), 3859-66", "doi": "10.1021/jf100530c", "pmid": "20192205", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00185", "slug": "huang-2010-promoting-effect-of-antrodia", "title": "Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine.", "authors": "Huang, Chia-Hsin; Chang, Chia-Che; Lin, Chiu-Mei; Wang, Sin-Ting; Wu, Min-Tze; Li, Eric I C; Chang, Hsien-Chang; Lin, Chi-Chen", "year": 2010, "journal": "Cancer immunology, immunotherapy : CII, 59(8), 1259-72", "doi": "10.1007/s00262-010-0852-y", "pmid": "20390417", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00186", "slug": "huang-2010-analgesic-effects-and-the", "title": "Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice.", "authors": "Huang, Guan-Jhong; Huang, Shyh-Shyun; Lin, Shiang-Shiou; Shao, Yi-Yuan; Chen, Chin-Chu; Hou, Wen-Chi; Kuo, Yueh-Hsiung", "year": 2010, "journal": "Journal of agricultural and food chemistry, 58(12), 7445-52", "doi": "10.1021/jf1013764", "pmid": "20507140", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00187", "slug": "huang-2010-optimization-of-alkaline-extraction", "title": "Optimization of alkaline extraction of polysaccharides from Ganoderma lucidum and their effect on immune function in mice.", "authors": "Huang, Sheng-Quan; Li, Jin-Wei; Wang, Zhou; Pan, Hua-Xin; Chen, Jiang-Xu; Ning, Zheng-Xiang", "year": 2010, "journal": "Molecules (Basel, Switzerland), 15(5), 3694-708", "doi": "10.3390/molecules15053694", "pmid": "20657508", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00188", "slug": "kim-2010-cordlan-polysaccharide-isolated-from", "title": "Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings.", "authors": "Kim, Hyung Sook; Kim, Jee Youn; Kang, Jong Soon; Kim, Hwan Mook; Kim, Yong Ook; Hong, In Pyo; Lee, Mi Kyeong; Hong, Jin Tae; Kim, Youngsoo; Han, Sang-Bae", "year": 2010, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(7), 1926-33", "doi": "10.1016/j.fct.2010.04.036", "pmid": "20434503", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00189", "slug": "largeteau-2010-microbially-induced-diseases-of", "title": "Microbially induced diseases of Agaricus bisporus: biochemical mechanisms and impact on commercial mushroom production.", "authors": "Largeteau, Michèle L; Savoie, Jean-Michel", "year": 2010, "journal": "Applied microbiology and biotechnology, 86(1), 63-73", "doi": "10.1007/s00253-010-2445-2", "pmid": "20127233", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00190", "slug": "lavi-2010-orally-administered-glucans-from", "title": "Orally administered glucans from the edible mushroom Pleurotus pulmonarius reduce acute inflammation in dextran sulfate sodium-induced experimental colitis.", "authors": "Lavi, Iris; Levinson, Dana; Peri, Irena; Nimri, Lili; Hadar, Yitzhak; Schwartz, Betty", "year": 2010, "journal": "The British journal of nutrition, 103(3), 393-402", "doi": "10.1017/S0007114509991760", "pmid": "19772681", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00191", "slug": "li-2010-protective-effects-on-mitochondria", "title": "Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris.", "authors": "Li, Xing-Tai; Li, Hong-Cheng; Li, Chun-Bin; Dou, De-Qiang; Gao, Ming-Bo", "year": 2010, "journal": "The American journal of Chinese medicine, 38(6), 1093-106", "doi": null, "pmid": "21061463", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00192", "slug": "liu-2010-administration-of-polysaccharides-from", "title": "Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma.", "authors": "Liu, Ko-Jiunn; Leu, Sy-Jye; Su, Ching-Hua; Chiang, Bor-Luen; Chen, Yi-Lien; Lee, Yueh-Lun", "year": 2010, "journal": "Immunology, 129(3), 351-62", "doi": "10.1111/j.1365-2567.2009.03175.x", "pmid": "19909376", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00193", "slug": "mancheno-2010-laetiporus-sulphureus-lectin-and", "title": "Laetiporus sulphureus lectin and aerolysin protein family.", "authors": "Mancheño, José Miguel; Tateno, Hiroaki; Sher, Daniel; Goldstein, Irwin J", "year": 2010, "journal": "Advances in experimental medicine and biology, 677, 67-80", "doi": null, "pmid": "20687481", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00194", "slug": "nagano-2010-reduction-of-depression-and", "title": "Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.", "authors": "Nagano, Mayumi; Shimizu, Kuniyoshi; Kondo, Ryuichiro; Hayashi, Chickako; Sato, Daigo; Kitagawa, Katsuyuki; Ohnuki, Koichiro", "year": 2010, "journal": "Biomedical research (Tokyo, Japan), 31(4), 231-7", "doi": null, "pmid": "20834180", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00195", "slug": "oh-2010-semipurified-fractions-from-the", "title": "Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats.", "authors": "Oh, Tae W; Kim, Yun A; Jang, Wook J; Byeon, Jae I; Ryu, Chung H; Kim, Jeong O; Ha, Yeong L", "year": 2010, "journal": "Journal of agricultural and food chemistry, 58(7), 4113-9", "doi": "10.1021/jf9036672", "pmid": "20196600", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00196", "slug": "preuss-2010-maitake-mushroom-extracts-ameliorate", "title": "Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats.", "authors": "Preuss, Harry G; Echard, Bobby; Bagchi, Debasis; Perricone, Nicholas V", "year": 2010, "journal": "International journal of medical sciences, 7(4), 169-80", "doi": null, "pmid": "20567593", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00197", "slug": "shin-2010-dietary-mushroom-intake-and", "title": "Dietary mushroom intake and the risk of breast cancer based on hormone receptor status.", "authors": "Shin, Aesun; Kim, Jeongseon; Lim, Sun-Young; Kim, Gaeul; Sung, Mi-Kyung; Lee, Eun-Sook; Ro, Jungsil", "year": 2010, "journal": "Nutrition and cancer, 62(4), 476-83", "doi": "10.1080/01635580903441212", "pmid": "20432168", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00198", "slug": "song-2010-isolation-of-a-polysaccharide", "title": "Isolation of a polysaccharide with anticancer activity from Auricularia polytricha using high-speed countercurrent chromatography with an aqueous two-phase system.", "authors": "Song, Guanglei; Du, Qizhen", "year": 2010, "journal": "Journal of chromatography. 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Wei, Song; Baars, Johan J P; van Griensven, Leo J L D; Sonnenberg, Anton S M; Mensink, Ronald P; Plat, Jogchum", "year": 2010, "journal": "Molecular nutrition & food research, 54(2), 268-76", "doi": "10.1002/mnfr.200900009", "pmid": "19885842", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00201", "slug": "wu-2010-chemical-characterization-of-auricularia", "title": "Chemical characterization of Auricularia auricula polysaccharides and its pharmacological effect on heart antioxidant enzyme activities and left ventricular function in aged mice.", "authors": "Wu, Qin; Tan, Zhiping; Liu, Haidan; Gao, Lei; Wu, Sijie; Luo, Jinwen; Zhang, Weizhi; Zhao, Tianli; Yu, Jiefeng; Xu, Xinhua", "year": 2010, "journal": "International journal of biological macromolecules, 46(3), 284-8", "doi": "10.1016/j.ijbiomac.2010.01.016", "pmid": "20105437", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00202", "slug": "zhao-2010-quality-evaluation-of-mycelial", "title": "Quality evaluation of mycelial Antrodia camphorata using high-performance liquid chromatography (HPLC) coupled with diode array detector and mass spectrometry (DAD-MS).", "authors": "Zhao, Sandy Shuo; Leung, Kelvin Sze-Yin", "year": 2010, "journal": "Chinese medicine, 5, 4", "doi": "10.1186/1749-8546-5-4", "pmid": "20205903", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00203", "slug": "abrams-2011-antihyperlipidemic-effects-of-pleurotus", "title": "Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy.", "authors": "Abrams, Donald I; Couey, Paul; Shade, Starley B; Kelly, Mary Ellen; Kamanu-Elias, Nnemdi; Stamets, Paul", "year": 2011, "journal": "BMC complementary and alternative medicine, 11, 60", "doi": "10.1186/1472-6882-11-60", "pmid": "21831304", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00204", "slug": "alam-2011-dietary-effect-of-pleurotus", "title": "Dietary effect of Pleurotus eryngii on biochemical function and histology in hypercholesterolemic rats.", "authors": "Alam, Nuhu; Yoon, Ki Nam; Lee, Jae Seong; Cho, Hae Jin; Shim, Mi Ja; Lee, Tae Soo", "year": 2011, "journal": "Saudi journal of biological sciences, 18(4), 403-9", "doi": "10.1016/j.sjbs.2011.07.001", "pmid": "23961153", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00205", "slug": "bouike-2011-oral-treatment-with-extract", "title": "Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice.", "authors": "Bouike, Go; Nishitani, Yosuke; Shiomi, Hideyuki; Yoshida, Masaru; Azuma, Takeshi; Hashimoto, Takashi; Kanazawa, Kazuki; Mizuno, Masashi", "year": 2011, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2011", "doi": "10.1155/2011/532180", "pmid": "20953432", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00206", "slug": "chang-2011-an-extract-of-antrodia", "title": "An Extract of Antrodia camphorata Mycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice.", "authors": "Chang, Jia-Ming; Lee, Yi-Ru; Hung, Le-Mei; Liu, Sheng-Yung; Kuo, Mao-Tien; Wen, Wu-Che; Chen, Peini", "year": 2011, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2011, 465894", "doi": "10.1093/ecam/nen057", "pmid": "18955361", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00207", "slug": "chang-2011-carbon-tetrachlorideinduced-hepatotoxicity-and", "title": "Carbon tetrachloride-induced hepatotoxicity and its amelioration by Agaricus blazei Murrill extract in a mouse model.", "authors": "Chang, Jin-Biou; Wu, Ming-Fang; Yang, Yi-Yuan; Leu, Sy-Jye; Chen, Yung-Liang; Yu, Chun-Shu; Yu, Chieh-Chih; Chang, Shu-Jen; Lu, Hsu-Feng; Chung, Jing-Gung", "year": 2011, "journal": "In vivo (Athens, Greece), 25(6), 971-6", "doi": null, "pmid": "22021691", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00208", "slug": "chen-2011-hypocholesterolemic-effects-of-auricularia", "title": "Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet.", "authors": "Chen, Gang; Luo, Yang-Chao; Ji, Bao-Ping; Li, Bo; Su, Wei; Xiao, Zhen-Lei; Zhang, Gui-Zhi", "year": 2011, "journal": "Journal of food science and technology, 48(6), 692-8", "doi": "10.1007/s13197-010-0196-9", "pmid": "23572806", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00209", "slug": "chen-2011-a-90day-subchronic-toxicological", "title": "A 90-day subchronic toxicological assessment of Antrodia cinnamomea in Sprague-Dawley rats.", "authors": "Chen, Tai-I; Chen, Chin-Chu; Lin, Ting-Wei; Tsai, Yueh-Ting; Nam, Mun-Kit", "year": 2011, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(2), 429-33", "doi": "10.1016/j.fct.2010.11.018", "pmid": "21093523", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00210", "slug": "chen-2011-antcin-a-a-steroidlike", "title": "Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids.", "authors": "Chen, Yi-ching; 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Benzie, Iris F F; Lam, Christopher W K; Fok, Benny S P; Lee, Kenneth K C; Tomlinson, Brian", "year": 2012, "journal": "The British journal of nutrition, 107(7), 1017-27", "doi": "10.1017/S0007114511003795", "pmid": "21801467", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00248", "slug": "dong-2012-a-novel-watersoluble-dglucan", "title": "A novel water-soluble β-D-glucan isolated from the spores of Ganoderma lucidum.", "authors": "Dong, Qun; Wang, Ying; Shi, Lei; Yao, Jian; Li, Jie; Ma, Fangli; Ding, Kan", "year": 2012, "journal": "Carbohydrate research, 353, 100-5", "doi": "10.1016/j.carres.2012.02.029", "pmid": "22486826", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00249", "slug": "huang-2012-the-antitumorigenic-mushroom-agaricus", "title": "The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages.", "authors": "Huang, Tsung-Teng; Ojcius, David M; Young, John D; Wu, Yi-Hui; Ko, Yun-Fei; Wong, Tsui-Yin; Wu, Cheng-Yeu; Lu, Chia-Chen; Lai, Hsin-Chih", "year": 2012, "journal": "PloS one, 7(7), e41383", "doi": "10.1371/journal.pone.0041383", "pmid": "22844468", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00250", "slug": "griffiths-2008-mysticaltype-experiences-occasioned-by", "title": "Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later.", "authors": "Griffiths, Roland R; Richards, William A; Johnson, Matthew W; McCann, Una D; Jesse, Robert", "year": 2008, "journal": "Journal of Psychopharmacology, 22(6), 621-632", "doi": "10.1177/0269881108094300", "pmid": "18593735", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00251", "slug": "jeong-2012-dietary-intake-of-agaricus", "title": "Dietary intake of Agaricus bisporus white button mushroom accelerates salivary immunoglobulin A secretion in healthy volunteers.", "authors": "Jeong, Sang Chul; Koyyalamudi, Sundar Rao; Pang, Gerald", "year": 2012, "journal": "Nutrition (Burbank, Los Angeles County, Calif.), 28(5), 527-31", "doi": "10.1016/j.nut.2011.08.005", "pmid": "22113068", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00252", "slug": "lee-2012-anticancer-effects-of-eleven", "title": "Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.", "authors": "Lee, Yi-Pang; Tsai, Wan-Chi; Ko, Chih-Jan; Rao, Yerra Koteswara; Yang, Chiung-Ru; Chen, Dar-Ren; Yang, Ming-Hui; Yang, Chi-Chiang; Tzeng, Yew-Min", "year": 2012, "journal": "Anticancer research, 32(7), 2727-34", "doi": null, "pmid": "22753732", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00253", "slug": "li-2012-cordyceps-militaris-extract-attenuates", "title": "Cordyceps militaris extract attenuates D-galactose-induced memory impairment in mice.", "authors": "Li, Zaixin; Zhang, Zhi; Zhang, Jinshan; Jia, Jing; Ding, Jie; Luo, Rongzhen; Liu, Zhangqin", "year": 2012, "journal": "Journal of medicinal food, 15(12), 1057-63", "doi": "10.1089/jmf.2011.2105", "pmid": "23216110", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00254", "slug": "lima-2012-agaricus-blazei-murrill-and", "title": "Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial.", "authors": "Lima, C U J O; Souza, V C; Morita, M C; Chiarello, M D; Karnikowski, M G de Oliveira", "year": 2012, "journal": "Scandinavian journal of immunology, 75(3), 336-41", "doi": "10.1111/j.1365-3083.2011.02656.x", "pmid": "22010847", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00255", "slug": "liu-2012-protective-effects-of-antrodia", "title": "Protective effects of Antrodia cinnamomea against liver injury.", "authors": "Liu, Yen-Wenn; Lu, Kuan-Hung; Ho, Chi-Tang; Sheen, Lee-Yan", "year": 2012, "journal": "Journal of traditional and complementary medicine, 2(4), 284-94", "doi": null, "pmid": "24716143", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00256", "slug": "lo-2012-comparative-study-of-contents", "title": "Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms.", "authors": "Lo, Yu-Chang; Lin, Shin-Yi; Ulziijargal, Enkhjargal; Chen, Shin-Yu; Chien, Rao-Chi; Tzou, Yi-Jing; Mau, Jeng-Leun", "year": 2012, "journal": "International journal of medicinal mushrooms, 14(4), 357-63", "doi": null, "pmid": "23510173", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00257", "slug": "meng-2012-polysaccharides-from-extracts-of", "title": "Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis.", "authors": "Meng, Ling-Min; Pai, Man-Hui; Liu, Jun-Jen; Yeh, Sung-Ling", "year": 2012, "journal": "Nutrition (Burbank, Los Angeles County, Calif.), 28(9), 942-9", "doi": "10.1016/j.nut.2012.01.006", "pmid": "22541057", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00258", "slug": "mishra-2012-orally-administered-aqueous-extract", "title": "Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice.", "authors": "Mishra, Siddhartha Kumar; Kang, Ju-Hee; Kim, Dong-Kyu; Oh, Seung Hyun; Kim, Mi Kyung", "year": 2012, "journal": "Journal of ethnopharmacology, 143(2), 524-32", "doi": "10.1016/j.jep.2012.07.008", "pmid": "22819687", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00259", "slug": "nguyen-2012-immunoenhancing-activity-of-sulfated", "title": "Immuno-enhancing activity of sulfated Auricularia auricula polysaccharides.", "authors": "Nguyen, The Luong; Wang, Deyun; Hu, Yuanliang; Fan, Yunpeng; Wang, Junmin; Abula, Saifuding; Guo, Liwei; Zhang, Jing; khakame, Shem Kakai; Dang, Bao Khanh", "year": 2012, "journal": "Carbohydrate polymers, 89(4), 1117-22", "doi": "10.1016/j.carbpol.2012.03.082", "pmid": "24750922", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00260", "slug": "phan-2012-potential-uses-of-spent", "title": "Potential uses of spent mushroom substrate and its associated lignocellulosic enzymes.", "authors": "Phan, Chia-Wei; Sabaratnam, Vikineswary", "year": 2012, "journal": "Applied microbiology and biotechnology, 96(4), 863-73", "doi": "10.1007/s00253-012-4446-9", "pmid": "23053096", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00261", "slug": "phillips-2012-vitamin-d4-in-mushrooms", "title": "Vitamin D4 in mushrooms.", "authors": "Phillips, Katherine M; Horst, Ronald L; Koszewski, Nicholas J; Simon, Ryan R", "year": 2012, "journal": "PloS one, 7(8), e40702", "doi": "10.1371/journal.pone.0040702", "pmid": "22870201", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00262", "slug": "preuss-2012-fraction-sx-of-maitake", "title": "Fraction SX of maitake mushroom favorably influences blood glucose levels and blood pressure in streptozotocin-induced diabetic rats.", "authors": "Preuss, Harry G; Echard, Bobby; Fu, Jia; Perricone, Nicholas V; Bagchi, Debasis; Kaylor, Mark; Zhuang, Cun", "year": 2012, "journal": "Journal of medicinal food, 15(10), 901-8", "doi": "10.1089/jmf.2012.0011", "pmid": "22873755", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00263", "slug": "song-2012-antiinflammatory-and-antiallergic-effect", "title": "Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells.", "authors": "Song, Hyuk-Hwan; Chae, Hee-Sung; Oh, Sei-Ryang; Lee, Hyeong-Kyu; Chin, Young-Won", "year": 2012, "journal": "The American journal of Chinese medicine, 40(5), 1073-84", "doi": "10.1142/S0192415X12500796", "pmid": "22928836", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00264", "slug": "stamets-2012-trametes-versicolor-turkey-tail", "title": "Trametes versicolor (Turkey Tail Mushrooms) and the Treatment of Breast Cancer.", "authors": "Stamets, Paul", "year": 2012, "journal": "Global advances in health and medicine, 1(5), 20", "doi": "10.7453/gahmj.2012.1.5.007", "pmid": "27257526", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00265", "slug": "teplyakova-2012-antiviral-activity-of-polyporoid", "title": "Antiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altai Mountains (Russia).", "authors": "Teplyakova, Tamara V; Psurtseva, Nadezhda V; Kosogova, Tatiana A; Mazurkova, Natalia A; Khanin, Viacheslav A; Vlasenko, Viacheslav A", "year": 2012, "journal": "International journal of medicinal mushrooms, 14(1), 37-45", "doi": null, "pmid": "22339706", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00266", "slug": "teplyakova-2012-antiviral-activity-of-polyporoid-2", "title": "Antiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altai Mountains (Russia).", "authors": "Teplyakova, Tamara V; Psurtseva, Nadezhda V; Kosogova, Tatiana A; Mazurkova, Natalia A; Khanin, Viacheslav A; Vlasenko, Viacheslav A", "year": 2012, "journal": "International journal of medicinal mushrooms, 14(1), 37-45", "doi": null, "pmid": "22339706", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00267", "slug": "torkelson-2012-phase-1-clinical-trial", "title": "Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer.", "authors": "Torkelson, Carolyn J; Sweet, Erin; Martzen, Mark R; Sasagawa, Masa; Wenner, Cynthia A; Gay, Juliette; Putiri, Amy; Standish, Leanna J", "year": 2012, "journal": "ISRN oncology, 2012, 251632", "doi": "10.5402/2012/251632", "pmid": "22701186", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00268", "slug": "tung-2012-ethanolic-extract-of-agaricus", "title": "Ethanolic Extract of Agaricus blazei Fermentation Product Inhibits the Growth and Invasion of Human Hepatoma HA22T/VGH and SK-Hep-1 Cells.", "authors": "Tung, Yen-Chen; Su, Zheng-Yuan; Kuo, Min-Liang; Sheen, Lee-Yan", "year": 2012, "journal": "Journal of traditional and complementary medicine, 2(2), 145-53", "doi": null, "pmid": "24716127", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00269", "slug": "wang-2012-in-vitro-and-in", "title": "In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment.", "authors": "Wang, Li-Chun; Wang, Shen-En; Wang, Jyh-Jye; Tsai, Tsung-Yu; Lin, Chun-Hong; Pan, Tzu-Ming; Lee, Chun-Lin", "year": 2012, "journal": "Applied microbiology and biotechnology, 94(6), 1505-19", "doi": "10.1007/s00253-012-3941-3", "pmid": "22350319", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00270", "slug": "weigand-heller-2012-the-bioavailability-of-ergothioneine", "title": "The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation.", "authors": "Weigand-Heller, AuBrei J; Kris-Etherton, Penny M; Beelman, Robert B", "year": 2012, "journal": "Preventive medicine, 54 Suppl, S75-8", "doi": "10.1016/j.ypmed.2011.12.028", "pmid": "22230474", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00271", "slug": "sliva-2008-phellinus-linteus-suppresses-growth", "title": "Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling.", "authors": "Sliva, D; Jedinak, A; Kawasaki, J; Harvey, K; Slivova, V", "year": 2008, "journal": "British journal of cancer, 98(8), 1348-56", "doi": "10.1038/sj.bjc.6604319", "pmid": "18362935", "tags": ["cancer-oncology"], "studyType": "Multi-assay in-vitro breast-cancer and endothelial-cell study using a commercial aqueous Phellinus linteus extract plus pharmacologic AKT controls.", "evidenceStrength": "This is materially stronger than a single readout extract paper because it lines up growth, colony formation, invasion, endothelial morphogenesis, VEGF secretion, and AKT signaling in one system. The main weaknesses are material uncertainty and translation: the extract is not chemically standardized, most outcomes are presented as figure-driven dose responses rather than exact endpoint tables, and there is no breast-cancer animal model.", "keyFinding": "The intervention is not a purified polysaccharide or isolated mushroom compound. It is a commercial aqueous Phellinus linteus extract with no batch chemistry or active-fraction analysis in the paper.\n\nPL suppressed breast-cancer growth more than cell viability, especially in the 72-hour 1.0 mg/mL lane, which makes the main growth claim more cytostatic than directly cytotoxic.\n\nThe MDA-MB-231 cell-cycle result is not generic arrest language. The paper shows a specific S-phase build from 27% to 34% and 44% with p27 upregulation and without a matching apoptotic sub-G0 or G1 spike.\n\nThe anti-invasive lane is broader than a single migration assay, because adhesion, migration, invasion, and uPA secretion all move down together in the invasive MDA-MB-231 model.\n\nThe angiogenesis story is meaningful but capped. Direct PL exposure, PL-conditioned media, lower VEGF secretion, and lower p-AKT all point in the same direction, yet the conditioned-media lane remains partly confounded because the authors say they could not remove PL from that media.\n\nThis 2008 paper gives Phellinus linteus a real but narrow breast-cancer cell-culture signal. A commercial aqueous extract slowed growth mostly through cytostatic S-phase arrest, reduced adhesion, migration, invasion, uPA, endothelial tube formation, and VEGF, and lowered AKT phosphorylation in MDA-MB-231 cells. It does not identify the active molecule or show that the same effect happens in breast tumors in animals or people."}, {"rthcId": "RTHM-00272", "slug": "xu-2012-glucan-from-lentinus-edodes", "title": "β-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages.", "authors": "Xu, Xiaojuan; Yasuda, Michiko; Nakamura-Tsuruta, Sachiko; Mizuno, Masashi; Ashida, Hitoshi", "year": 2012, "journal": "The Journal of biological chemistry, 287(2), 871-8", "doi": "10.1074/jbc.M111.297887", "pmid": "22102286", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00273", "slug": "yamanaka-2012-effect-of-agaricus-brasiliensisderived", "title": "Effect of Agaricus brasiliensis-derived cold water extract on Toll-like receptor 2-dependent cytokine production in vitro.", "authors": "Yamanaka, Daisuke; Motoi, Masuro; Ishibashi, Ken-ichi; Miura, Noriko N; Adachi, Yoshiyuki; Ohno, Naohito", "year": 2012, "journal": "Immunopharmacology and immunotoxicology, 34(4), 561-70", "doi": "10.3109/08923973.2011.633526", "pmid": "22126586", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00274", "slug": "yue-2012-review-of-biological-and", "title": "Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).", "authors": "Yue, Patrick Ying-Kit; Wong, Yi-Yi; Chan, Tony Yuk-Kit; Law, Carman Ka-Man; Tsoi, Yeuk-Ki; Leung, Kelvin Sze-Yin", "year": 2012, "journal": "International journal of medicinal mushrooms, 14(3), 241-56", "doi": null, "pmid": "22577975", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00275", "slug": "zeng-2012-characterization-of-antioxidant-polysaccharides", "title": "Characterization of antioxidant polysaccharides from Auricularia auricular using microwave-assisted extraction.", "authors": "Zeng, Wei-Cai; Zhang, Zeng; Gao, Hong; Jia, Li-Rong; Chen, Wu-Yong", "year": 2012, "journal": "Carbohydrate polymers, 89(2), 694-700", "doi": "10.1016/j.carbpol.2012.03.078", "pmid": "24750775", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00276", "slug": "zhao-2012-spore-powder-of-ganoderma", "title": "Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial.", "authors": "Zhao, Hong; Zhang, Qingyuan; Zhao, Ling; Huang, Xu; Wang, Jincai; Kang, Xinmei", "year": 2012, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2012, 809614", "doi": "10.1155/2012/809614", "pmid": "22203880", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00277", "slug": "atli-2013-optimization-of-submerged-fermentation", "title": "Optimization of submerged fermentation conditions for lovastatin production by the culinary-medicinal oyster mushroom, Pleurotus ostreatus (Higher Basidiomycetes).", "authors": "Atli, Burcu; Yamac, Mustafa; Yildiz, Zeki", "year": 2013, "journal": "International journal of medicinal mushrooms, 15(5), 487-95", "doi": null, "pmid": "24266373", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00278", "slug": "auinger-2013-yeast-1316betaglucan-helps-to", "title": "Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects.", "authors": "Auinger, Annegret; Riede, Linda; Bothe, Gordana; Busch, Regina; Gruenwald, Joerg", "year": 2013, "journal": "European journal of nutrition, 52(8), 1913-8", "doi": "10.1007/s00394-013-0492-z", "pmid": "23340963", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00279", "slug": "catlow-2013-effects-of-psilocybin-on", "title": "Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning.", "authors": "Catlow, Briony J; Song, Shijie; Paredes, Daniel A; Kirstein, Cheryl L; Sanchez-Ramos, Juan", "year": 2013, "journal": "Experimental brain research, 228(4), 481-91", "doi": "10.1007/s00221-013-3579-0", "pmid": "23727882", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00280", "slug": "cha-2013-protective-effect-of-cordycepinenriched", "title": "Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague-Dawley rats.", "authors": "Cha, Jae-Young; Ahn, Hee-Young; Cho, Young-Su; Je, Jae-Young", "year": 2013, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 60, 52-7", "doi": "10.1016/j.fct.2013.07.033", "pmid": "23876821", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00281", "slug": "cheng-2013-aqueous-extracts-of-cordyceps", "title": "Aqueous extracts of Cordyceps militaris (Ascomycetes) lower the levels of plasma glucose by activating the cholinergic nerve in streptozotocin-induced diabetic rats.", "authors": "Cheng, Yu-Wen; Chen, Ying-I; Tzeng, Chung-Yuh; Chang, Chin-Hsien; Lee, Yu-Chen; Chen, Hong-Chen; Tsai, Chin-Chun; Hsu, Tai-Hao; Lai, Yiu-Kay; Chang, Shih-Liang", "year": 2013, "journal": "International journal of medicinal mushrooms, 15(3), 277-86", "doi": null, "pmid": "23662615", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00282", "slug": "chiu-2013-physicochemical-characteristics-and-antiinflammatory", "title": "Physicochemical characteristics and anti-inflammatory activities of antrodan, a novel glycoprotein isolated from Antrodia cinnamomea mycelia.", "authors": "Chiu, Chun-Hung; Peng, Chiung-Chi; Ker, Yaw-Bee; Chen, Chin-Chu; Lee, Arwen; Chang, Wan-Lin; Chyau, Charng-Cherng; Peng, Robert Y", "year": 2013, "journal": "Molecules (Basel, Switzerland), 19(1), 22-40", "doi": "10.3390/molecules19010022", "pmid": "24451244", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00283", "slug": "debnath-2013-antioxidant-and-antiinflammatory-activities", "title": "Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts.", "authors": "Debnath, Trishna; Park, Sa Ra; Kim, Da Hye; Jo, Jeong Eun; Lim, Beong Ou", "year": 2013, "journal": "Molecules (Basel, Switzerland), 18(8), 9293-304", "doi": "10.3390/molecules18089293", "pmid": "23917116", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00284", "slug": "deng-2013-analgesic-and-antiinflammatory-bioactivities", "title": "Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.", "authors": "Deng, Jeng-Shyan; Huang, Shyh-Shyun; Lin, Tsung-Hui; Lee, Min-Min; Kuo, Ching-Chuan; Sung, Ping-Jyun; Hou, Wen-Chi; Huang, Guan-Jhong; Kuo, Yueh-Hsiung", "year": 2013, "journal": "Journal of agricultural and food chemistry, 61(21), 5064-71", "doi": "10.1021/jf303820k", "pmid": "23495748", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00285", "slug": "geng-2013-antrodia-camphorata-atcc-200183", "title": "Antrodia camphorata ATCC 200183 sporulates asexually in submerged culture.", "authors": "Geng, Yan; He, Zhe; Lu, Zhen-Ming; Xu, Hong-Yu; Xu, Guo-Hua; Shi, Jin-Song; Xu, Zheng-Hong", "year": 2013, "journal": "Applied microbiology and biotechnology, 97(7), 2851-8", "doi": "10.1007/s00253-012-4513-2", "pmid": "23104644", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00286", "slug": "gokila-2013-antcin-c-from-antrodia", "title": "Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism.", "authors": "Gokila Vani, M; Kumar, K J Senthil; Liao, Jiunn-Wang; Chien, Shih-Chang; Mau, Jeng-Leun; Chiang, Shen-Shih; Lin, Chin-Chung; Kuo, Yueh-Hsiung; Wang, Sheng-Yang", "year": 2013, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2013, 296082", "doi": "10.1155/2013/296082", "pmid": "24391672", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00287", "slug": "hisamochi-2013-druginduced-liver-injury-associated", "title": "Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis.", "authors": "Hisamochi, Akiko; Kage, Masayoshi; Arinaga, Teruko; Ide, Tatsuya; Miyajima, Ichiro; Ogata, Kei; Kuwahara, Reiichiro; Koga, Yuriko; Kumashiro, Ryukichi; Sata, Michio", "year": 2013, "journal": "Clinical journal of gastroenterology, 6(2), 139-44", "doi": "10.1007/s12328-013-0359-0", "pmid": "26181451", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00288", "slug": "hu-2013-cordycepin-increases-nonrapid-eye", "title": "Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats.", "authors": "Hu, Zhenzhen; 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Park, Hye-Jin", "year": 2013, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2013, 914524", "doi": "10.1155/2013/914524", "pmid": "23818935", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00303", "slug": "peng-2013-antifibrotic-effect-of-cordyceps", "title": "Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs.", "authors": "Peng, Jinghua; Li, Xuemei; Feng, Qin; Chen, Liang; Xu, Lili; Hu, Yiyang", "year": 2013, "journal": "Experimental biology and medicine (Maywood, N.J.), 238(6), 668-77", "doi": "10.1177/1535370213480741", "pmid": "23918878", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00304", "slug": "shang-2013-in-vitro-antihelicobacter-pylori", "title": "In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion's Mane mushroom, Hericium erinaceus (higher Basidiomycetes).", "authors": "Shang, Xiaodong; Tan, Qi; Liu, Ruina; Yu, Kangying; Li, Pingzuo; Zhao, Guo-Ping", "year": 2013, "journal": "International journal of medicinal mushrooms, 15(2), 165-74", "doi": null, "pmid": "23557368", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00305", "slug": "singh-2013-cordyceps-sinensis-increases-hypoxia", "title": "Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells.", "authors": "Singh, Mrinalini; Tulsawani, Rajkumar; Koganti, Praveen; Chauhan, Amitabh; Manickam, Manimaran; Misra, Kshipra", "year": 2013, "journal": "BioMed research international, 2013, 569206", "doi": "10.1155/2013/569206", "pmid": "24063008", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00306", "slug": "soares-2013-effects-of-an-agaricus", "title": "Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.", "authors": "Soares, Andréia A; de Oliveira, Andrea L; Sá-Nakanishi, Anacharis B; Comar, Jurandir F; Rampazzo, Ana P S; Vicentini, Fernando A; Natali, Maria R M; Gomes da Costa, Sandra M; Bracht, Adelar; Peralta, Rosane M", "year": 2013, "journal": "BioMed research international, 2013, 469180", "doi": "10.1155/2013/469180", "pmid": "23984368", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00307", "slug": "song-2013-regulation-of-the-exopolysaccharide", "title": "Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line.", "authors": "Song, Dan; He, Zhenyue; Wang, Chenhao; Yuan, Fengjiao; Dong, Ping; Zhang, Weiyun", "year": 2013, "journal": "European journal of nutrition, 52(2), 687-94", "doi": "10.1007/s00394-012-0373-x", "pmid": "22610670", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00308", "slug": "vincent-2013-dietary-supplementation-with-agaricus", "title": "Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats.", "authors": "Vincent, Mylène; Philippe, Erwann; Everard, Amandine; Kassis, Nadim; Rouch, Claude; Denom, Jessica; Takeda, Yorihiko; Uchiyama, Shoji; Delzenne, Nathalie M; Cani, Patrice D; Migrenne, Stéphanie; Magnan, Christophe", "year": 2013, "journal": "Obesity (Silver Spring, Md.), 21(3), 553-61", "doi": "10.1002/oby.20276", "pmid": "23592663", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00309", "slug": "wang-2013-antrodia-camphoratafermented-product-cultured", "title": "Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.", "authors": "Wang, Li-Chun; Kuo, Iau-Uen; Tsai, Tsung-Yu; Lee, Chun-Lin", "year": 2013, "journal": "Applied microbiology and biotechnology, 97(23), 9955-67", "doi": "10.1007/s00253-013-5214-1", "pmid": "24061418", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00310", "slug": "yan-2013-cardiovascular-protection-and-antioxidant", "title": "Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors.", "authors": "Yan, Xiao-Feng; Zhang, Zhong-Miao; Yao, Hong-Yi; Guan, Yan; Zhu, Jian-Ping; Zhang, Lin-Hui; Jia, Yong-Liang; Wang, Ru-Wei", "year": 2013, "journal": "Phytotherapy research : PTR, 27(11), 1597-604", "doi": "10.1002/ptr.4899", "pmid": "23192916", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00311", "slug": "yang-2013-antroquinonol-mitigates-an-accelerated", "title": "Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.", "authors": "Yang, Shun-Min; Ka, Shuk-Man; Hua, Kuo-Feng; Wu, Tzu-Hua; Chuang, Yi-Ping; Lin, Ya-Wen; Yang, Feng-Ling; Wu, Shih-Hsiung; Yang, Sung-Sen; Lin, Shih-Hua; Chang, Jia-Ming; Chen, Ann", "year": 2013, "journal": "Free radical biology & medicine, 61, 285-97", "doi": "10.1016/j.freeradbiomed.2013.03.024", "pmid": "23567192", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00312", "slug": "yeh-2013-a-sesquiterpene-lactone-antrocin", "title": "A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.", "authors": "Yeh, Chi-Tai; Huang, Wen-Chien; Rao, Yerra Koteswara; Ye, Min; Lee, Wei-Hwa; Wang, Liang-Shun; Tzeng, David T W; Wu, Chih-Hsiung; Shieh, Yi-Shing; Huang, Chi-Ying F; Chen, Yu-Jen; Hsiao, Michael; Wu, Alexander T H; Yang, Zhen; Tzeng, Yew-Min", "year": 2013, "journal": "Carcinogenesis, 34(12), 2918-28", "doi": "10.1093/carcin/bgt255", "pmid": "23880305", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00313", "slug": "chen-2014-rhodiola-crenulata-and-cordyceps", "title": "Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training.", "authors": "Chen, Chung-Yu; Hou, Chien-Wen; Bernard, Jeffrey R; Chen, Chiu-Chou; Hung, Ta-Cheng; Cheng, Lu-Ling; Liao, Yi-Hung; Kuo, Chia-Hua", "year": 2014, "journal": "High altitude medicine & biology, 15(3), 371-9", "doi": "10.1089/ham.2013.1114", "pmid": "25251930", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00314", "slug": "cheng-2014-radioprotective-effects-of-antrodia", "title": "Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells.", "authors": "Cheng, Po-Ching; Huang, Chun-Chih; Chiang, Ping-Fang; Lin, Ching-Nan; Li, Li-Li; Lee, Te-Wei; Lin, Bin; Chen, I-Chen; Chang, Kang-Wei; Fan, Chia-Kwung; Luo, Tsai-Yueh", "year": 2014, "journal": "International journal of radiation biology, 90(10), 841-52", "doi": "10.3109/09553002.2014.911989", "pmid": "24708166", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00315", "slug": "cheng-2014-cordyceps-sinensis-prevents-apoptosis", "title": "Cordyceps sinensis prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure.", "authors": "Cheng, Yu-Jung; Cheng, Shiu-Min; Teng, Yi-Hsien; Shyu, Woei-Cherng; Chen, Hsiu-Ling; Lee, Shin-Da", "year": 2014, "journal": "The American journal of Chinese medicine, 42(2), 427-41", "doi": "10.1142/S0192415X14500281", "pmid": "24707872", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00316", "slug": "choi-2014-cordyceps-militaris-alleviates-nonalcoholic", "title": "Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice.", "authors": "Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In", "year": 2014, "journal": "Nutrition research and practice, 8(2), 172-6", "doi": "10.4162/nrp.2014.8.2.172", "pmid": "24741401", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00317", "slug": "choi-2014-antiinflammatory-effects-of-cordycepin", "title": "Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways.", "authors": "Choi, Yung Hyun; Kim, Gi-Young; Lee, Hye Hyeon", "year": 2014, "journal": "Drug design, development and therapy, 8, 1941-53", "doi": "10.2147/DDDT.S71957", "pmid": "25342887", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00318", "slug": "chung-2014-coenzyme-q0-from-antrodia", "title": "Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells.", "authors": "Chung, Cheng-Han; Yeh, Szu-Chien; Chen, Chun-Jen; Lee, Kung-Ta", "year": 2014, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2014, 246748", "doi": "10.1155/2014/246748", "pmid": "25431605", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00319", "slug": "diao-2014-protective-effect-of-polysaccharides", "title": "Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats.", "authors": "Diao, Bao-Zhong; Jin, Wei-Rong; Yu, Xue-Jing", "year": 2014, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2014, 841496", "doi": "10.1155/2014/841496", "pmid": "25093030", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00320", "slug": "fang-2014-concentrations-and-health-risks", "title": "Concentrations and health risks of lead, cadmium, arsenic, and mercury in rice and edible mushrooms in China.", "authors": "Fang, Yong; 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Zhong, Fang; Tang, Xu-long; Lian, Fu-lin; Zhou, Qiao; Guo, Shan-mai; Liu, Jia-fu; Sun, Peng; Hao, Xu; Lu, Ying; Wang, Wei-ming; Chen, Nan; Zhang, Nai-xia", "year": 2014, "journal": "Acta pharmacologica Sinica, 35(5), 697-706", "doi": "10.1038/aps.2013.186", "pmid": "24632844", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00338", "slug": "lu-2014-effect-of-antrodia-camphorata", "title": "Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.", "authors": "Lu, Wan-Jung; Lin, Shih-Chang; Lan, Chang-Chou; Lee, Tzu-Yin; Hsia, Chih-Hsuan; Huang, Yung-Kai; Lee, Hsiu-Chuan; Sheu, Joen-Rong", "year": 2014, "journal": "TheScientificWorldJournal, 2014, 745802", "doi": "10.1155/2014/745802", "pmid": "25541625", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00339", "slug": "lu-2014-alphaterpineol-promotes-triterpenoid-production", "title": "Alpha-terpineol promotes triterpenoid production of Antrodia cinnamomea in submerged culture.", "authors": "Lu, Zhen-Ming; Geng, Yan; Li, Hua-Xiang; Sun, Qing; Shi, Jin-Song; Xu, Zheng-Hong", "year": 2014, "journal": "FEMS microbiology letters, 358(1), 36-43", "doi": "10.1111/1574-6968.12545", "pmid": "25053476", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00340", "slug": "mehrotra-2014-bioavailability-of-vitamin-d2", "title": "Bioavailability of vitamin D2 from enriched mushrooms in prediabetic adults: a randomized controlled trial.", "authors": "Mehrotra, A; Calvo, M S; Beelman, R B; Levy, E; Siuty, J; Kalaras, M D; Uribarri, J", "year": 2014, "journal": "European journal of clinical nutrition, 68(10), 1154-60", "doi": "10.1038/ejcn.2014.157", "pmid": "25117997", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00341", "slug": "ohyama-2014-effect-of-the-ethanol", "title": "Effect of the ethanol extract of Pleurotus eryngii on bone metabolism in ovariectomized rats.", "authors": "Ohyama, Y; Matsushita, H; Minami, A; Kanazawa, H; Suzuki, T; Watanabe, K; Wakatsuki, A", "year": 2014, "journal": "Climacteric : the journal of the International Menopause Society, 17(4), 492-9", "doi": "10.3109/13697137.2014.891197", "pmid": "24502200", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00342", "slug": "palanisamy-2014-pressurized-water-extraction-of", "title": "Pressurized water extraction of β-glucan enriched fractions with bile acids-binding capacities obtained from edible mushrooms.", "authors": "Palanisamy, Marimuthu; Aldars-García, Laila; Gil-Ramírez, Alicia; Ruiz-Rodríguez, Alejandro; Marín, Francisco R; Reglero, Guillermo; Soler-Rivas, Cristina", "year": 2014, "journal": "Biotechnology progress, 30(2), 391-400", "doi": "10.1002/btpr.1865", "pmid": "24399760", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00343", "slug": "park-2014-cordycepin-3deoxyadenosine-prevents-rat", "title": "Cordycepin, 3'-deoxyadenosine, prevents rat hearts from ischemia/reperfusion injury via activation of Akt/GSK-3β/p70S6K signaling pathway and HO-1 expression.", "authors": "Park, Eun-Seok; Kang, Do-Hyun; Yang, Min-Kyu; Kang, Jun Chul; Jang, Yong Chang; Park, Jong Seok; Kim, Si-Kwan; Shin, Hwa-Sup", "year": 2014, "journal": "Cardiovascular toxicology, 14(1), 1-9", "doi": "10.1007/s12012-013-9232-0", "pmid": "24178833", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00344", "slug": "peng-2014-ergosterol-is-the-active", "title": "Ergosterol Is the Active Compound of Cultured Mycelium Cordyceps sinensis on Antiliver Fibrosis.", "authors": "Peng, Yuan; Tao, Yanyan; Wang, Qinglan; Shen, Li; Yang, Tao; Liu, Zulong; Liu, Chenghai", "year": 2014, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2014, 537234", "doi": "10.1155/2014/537234", "pmid": "25386220", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00345", "slug": "petri-2014-homological-scaffolds-of-brain", "title": "Homological scaffolds of brain functional networks.", "authors": "Petri, G; Expert, P; Turkheimer, F; 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Qin, Dan; Zhao, Chen; Sun, Xiao-Le; Huang, Fang; Kong, Chao; Yang, Song", "year": 2014, "journal": "International journal of medicinal mushrooms, 16(1), 95-103", "doi": null, "pmid": "24940908", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00350", "slug": "sun-2014-effect-of-different-cooking", "title": "Effect of different cooking methods on total phenolic contents and antioxidant activities of four Boletus mushrooms.", "authors": "Sun, Liping; Bai, Xue; Zhuang, Yongliang", "year": 2014, "journal": "Journal of food science and technology, 51(11), 3362-8", "doi": "10.1007/s13197-012-0827-4", "pmid": "26396332", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00351", "slug": "thongklang-2014-evidence-for-amphithallism-and", "title": "Evidence for amphithallism and broad geographical hybridization potential among Agaricus subrufescens isolates from Brazil, France, and Thailand.", "authors": "Thongklang, Naritsada; 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Lee, Tzong-Huei; Hsu, Chun-Hua; Chang, Yu-Jia; Chang, Man-Shan; Wang, Yi-Ching; Ho, Yuan-Soon; Wen, Wu-Che; Lin, Ruo-Kai", "year": 2014, "journal": "Journal of agricultural and food chemistry, 62(24), 5625-35", "doi": "10.1021/jf4056924", "pmid": "24784321", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00356", "slug": "xia-2014-effect-of-cultural-conditions", "title": "Effect of cultural conditions on antrodin C production by basidiomycete Antrodia camphorata in solid-state fermentation.", "authors": "Xia, Yongjun; Wang, Yuanlong; Zhang, Bobo; Xu, Ganrong; Ai, Lianzhong", "year": 2014, "journal": "Biotechnology and applied biochemistry, 61(6), 724-32", "doi": "10.1002/bab.1220", "pmid": "24548184", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00357", "slug": "ying-2014-cordycepin-prevented-ilinduced-expression", "title": "Cordycepin prevented IL-β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.", "authors": "Ying, Xiaozhou; Peng, Lei; Chen, Hua; Shen, Yue; Yu, Kehe; Cheng, Shaowen", "year": 2014, "journal": "International orthopaedics, 38(7), 1519-26", "doi": "10.1007/s00264-013-2219-4", "pmid": "24346509", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00358", "slug": "yu-2014-auricularia-polytricha-polysaccharides-induce", "title": "Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells.", "authors": "Yu, Jie; Sun, Ruilin; Zhao, Zhongquan; Wang, Yingyu", "year": 2014, "journal": "International journal of biological macromolecules, 68, 67-71", "doi": "10.1016/j.ijbiomac.2014.04.018", "pmid": "24755260", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00359", "slug": "zhang-2014-the-effects-of-cordyceps", "title": "The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in ovariectomized rats.", "authors": "Zhang, Da-wei; Wang, Zhen-lin; 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Xu, Ying; Shen, Jie", "year": 2014, "journal": "International journal of molecular sciences, 15(7), 12119-34", "doi": "10.3390/ijms150712119", "pmid": "25007068", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00362", "slug": "zhang-2014-neuroprotective-effects-of-gualou", "title": "Neuroprotective effects of Gualou Guizhi decoction in vivo and in vitro.", "authors": "Zhang, Yuqin; Li, Huang; Huang, Mei; Chu, Kedan; Xu, Wei; Zhang, Shengnan; Que, Jinhua; Chen, Lidian", "year": 2014, "journal": "Journal of ethnopharmacology, 158 Pt A, 76-84", "doi": "10.1016/j.jep.2014.10.020", "pmid": "25456424", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00363", "slug": "zhu-2014-preparation-characterization-and-antihelicobacter", "title": "Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex.", "authors": "Zhu, Yang; Chen, Yao; Li, Qian; Zhao, Ting; 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Kuo, Hsiang-Ping; Chang, Ke Liang B; Kong, Zwe-Ling", "year": 2015, "journal": "PloS one, 10(9), e0136782", "doi": "10.1371/journal.pone.0136782", "pmid": "26327534", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00366", "slug": "chang-2015-antroquinonol-lowers-brain-amyloid", "title": "Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease.", "authors": "Chang, Wen-Han; Chen, Miles C; Cheng, Irene H", "year": 2015, "journal": "Scientific reports, 5, 15067", "doi": "10.1038/srep15067", "pmid": "26469245", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00367", "slug": "chen-2015-synergistic-effect-of-hmgb1", "title": "Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line.", "authors": "Chen, Xi; Wang, Ying; Liu, Juan; Xu, Ping; Zhang, Xiao-Min; Tian, Yao-Yao; Xue, Yan-Ming; 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González-Delgado, Purificación; Postigo, Idoia; Fernández, Javier; Soriano, Victor; Cueva, Begoña; Martínez, Jorge", "year": 2015, "journal": "Medical mycology case reports, 8, 14-6", "doi": "10.1016/j.mmcr.2015.02.003", "pmid": "25750856", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00373", "slug": "glamoclija-2015-chemical-characterization-and-biological", "title": "Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal \"mushroom\".", "authors": "Glamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Fernandes, Ângela; Barros, Lillian; Calhelha, Ricardo C; Ferreira, Isabel C F R; Soković, Marina; van Griensven, Leo J L D", "year": 2015, "journal": "Journal of ethnopharmacology, 162, 323-32", "doi": "10.1016/j.jep.2014.12.069", "pmid": "25576897", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00374", "slug": "hong-2015-hepatoprotective-activity-of-water", "title": "Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes.", "authors": "Hong, Ki Bae; Noh, Dong Ouk; Park, Yooheon; Suh, Hyung Joo", "year": 2015, "journal": "International journal of medicinal mushrooms, 17(11), 1069-76", "doi": null, "pmid": "26853962", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00375", "slug": "hong-2015-cordyceps-sinensis-a-traditional", "title": "Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients.", "authors": "Hong, Tao; Zhang, Minghua; Fan, Junming", "year": 2015, "journal": "The Cochrane database of systematic reviews, 2015(10), CD009698", "doi": "10.1002/14651858.CD009698.pub2", "pmid": "26457607", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00376", "slug": "hsieh-2015-effects-of-antrodia-camphorata", "title": "Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage.", "authors": "Hsieh, Yu-Lin; Wu, Szu-Pei; Fang, Li-Wen; Hwang, Tzann-Shun", "year": 2015, "journal": "BMC complementary and alternative medicine, 15, 237", "doi": "10.1186/s12906-015-0768-3", "pmid": "26179175", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00377", "slug": "huang-2015-antcin-k-an-active", "title": "Antcin K, an Active Triterpenoid from the Fruiting Bodies of Basswood-Cultivated Antrodia cinnamomea, Inhibits Metastasis via Suppression of Integrin-Mediated Adhesion, Migration, and Invasion in Human Hepatoma Cells.", "authors": "Huang, Ya-Ling; Chu, Yung-Lin; Ho, Chi-Tang; Chung, Jing-Gung; Lai, Chiao-I; Su, Yu-Cheng; Kuo, Yueh-Hsiung; Sheen, Lee-Yan", "year": 2015, "journal": "Journal of agricultural and food chemistry, 63(18), 4561-9", "doi": "10.1021/jf5059304", "pmid": "25911944", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00378", "slug": "kang-2015-cordyceps-militaris-enhances-cellmediated", "title": "Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men.", "authors": "Kang, Ho Joon; Baik, Hyun Wook; Kim, Sang Jung; Lee, Seong Gyu; Ahn, Hong Yup; Park, Ju Sang; Park, Sang Jong; Jang, Eun Jeong; Park, Sang Woon; Choi, Jin Young; Sung, Ji Hee; Lee, Seung Min", "year": 2015, "journal": "Journal of medicinal food, 18(10), 1164-72", "doi": "10.1089/jmf.2014.3350", "pmid": "26284906", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00379", "slug": "khaskheli-2015-characterization-of-auricularia-auricula", "title": "Characterization of Auricularia auricula polysaccharides and its antioxidant properties in fresh and pickled product.", "authors": "Khaskheli, Shahzor Gul; Zheng, Wen; Sheikh, Saghir Ahmed; Khaskheli, Ashfaque Ahmed; Liu, Ying; Soomro, Aijaz Hussain; Feng, Xi; Sauer, Mary Ball; Wang, Yan Feng; Huang, Wen", "year": 2015, "journal": "International journal of biological macromolecules, 81, 387-95", "doi": "10.1016/j.ijbiomac.2015.08.020", "pmid": "26277748", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00380", "slug": "klupp-2015-ganoderma-lucidum-mushroom-for", "title": "Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.", "authors": "Klupp, Nerida L; Chang, Dennis; Hawke, Fiona; Kiat, Hosen; Cao, Huijuan; Grant, Suzanne J; Bensoussan, Alan", "year": 2015, "journal": "The Cochrane database of systematic reviews, 2015(2), CD007259", "doi": "10.1002/14651858.CD007259.pub2", "pmid": "25686270", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00381", "slug": "kozarski-2015-nutraceutical-properties-of-the", "title": "Nutraceutical properties of the methanolic extract of edible mushroom Cantharellus cibarius (Fries): primary mechanisms.", "authors": "Kozarski, Maja; Klaus, Anita; Vunduk, Jovana; Zizak, Zeljko; Niksic, Miomir; Jakovljevic, Dragica; Vrvic, Miroslav M; Van Griensven, Leo J L D", "year": 2015, "journal": "Food & function, 6(6), 1875-86", "doi": "10.1039/c5fo00312a", "pmid": "25943486", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00382", "slug": "kuo-2015-ergostatrien3ol-from-antrodia-camphorata", "title": "Ergostatrien-3β-ol from Antrodia camphorata inhibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation.", "authors": "Kuo, Yueh-Hsiung; Lin, Cheng-Hsiu; Shih, Chun-Ching", "year": 2015, "journal": "Journal of agricultural and food chemistry, 63(9), 2479-89", "doi": "10.1021/acs.jafc.5b00073", "pmid": "25693659", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00383", "slug": "kuo-2015-antidiabetic-and-antihyperlipidemic-properties", "title": "Antidiabetic and Antihyperlipidemic Properties of a Triterpenoid Compound, Dehydroeburicoic Acid, from Antrodia camphorata in Vitro and in Streptozotocin-Induced Mice.", "authors": "Kuo, Yueh-Hsiung; Lin, Cheng-Hsiu; Shih, Chun-Ching", "year": 2015, "journal": "Journal of agricultural and food chemistry, 63(46), 10140-51", "doi": "10.1021/acs.jafc.5b04400", "pmid": "26503742", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00384", "slug": "lam-2015-determination-of-lovastatin-glucan", "title": "Determination of Lovastatin, β-glucan, Total Polyphenols, and Antioxidant Activity in Raw and Processed Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Higher Basidiomycetes).", "authors": "Lam, Yu Shan; Okello, Edward J", "year": 2015, "journal": "International journal of medicinal mushrooms, 17(2), 117-28", "doi": null, "pmid": "25746617", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00385", "slug": "lee-2015-antitumor-effect-of-cordyceps", "title": "Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells.", "authors": "Lee, Seulki; Lee, Hwan Hee; Kim, Jisung; Jung, Joohee; Moon, Aree; Jeong, Choon-Sik; Kang, Hyojeung; Cho, Hyosun", "year": 2015, "journal": "Journal of microbiology (Seoul, Korea), 53(7), 468-74", "doi": "10.1007/s12275-015-5198-x", "pmid": "26115996", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00386", "slug": "lee-2015-antroquinonol-from-antrodia-camphorata", "title": "Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.", "authors": "Lee, Wai-Theng; Lee, Tzong-Huei; Cheng, Chia-Hsiung; Chen, Ku-Chung; Chen, Yen-Chou; Lin, Cheng-Wei", "year": 2015, "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 78, 33-41", "doi": "10.1016/j.fct.2015.01.012", "pmid": "25656647", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00387", "slug": "lee-2015-a-phase-i-multicenter", "title": "A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.", "authors": "Lee, Yu-Chin; Ho, Ching-Liang; Kao, Woei-Yau; Chen, Yuh-Min", "year": 2015, "journal": "Molecular and clinical oncology, 3(6), 1375-1380", "doi": null, "pmid": "26807250", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00388", "slug": "li-2015-efficient-production-of-bioactive", "title": "Efficient production of bioactive metabolites from Antrodia camphorata ATCC 200183 by asexual reproduction-based repeated batch fermentation.", "authors": "Li, Hua-Xiang; Lu, Zhen-Ming; Geng, Yan; Gong, Jin-Song; Zhang, Xiao-Juan; Shi, Jin-Song; Xu, Zheng-Hong; Ma, Yan-He", "year": 2015, "journal": "Bioresource technology, 194, 334-43", "doi": "10.1016/j.biortech.2015.06.144", "pmid": "26210148", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00389", "slug": "li-2015-antrodia-cinnamomea-extract-inhibits", "title": "Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.", "authors": "Li, Ming-Han; Wu, Hsin-Chieh; Yao, Hsin-Jan; Lin, Chi-Chen; Wen, Shu-Fang; Pan, I-Horng", "year": 2015, "journal": "The American journal of Chinese medicine, 43(7), 1401-17", "doi": "10.1142/S0192415X15500792", "pmid": "26477794", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00390", "slug": "liao-2015-cordycepin-induces-cell-cycle", "title": "Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells.", "authors": "Liao, Yuanhong; Ling, Jianya; Zhang, Guoying; Liu, Fengjun; Tao, Shengce; Han, Zeguang; Chen, Saijuan; Chen, Zhu; Le, Huangying", "year": 2015, "journal": "Cell cycle (Georgetown, Tex.), 14(5), 761-71", "doi": "10.1080/15384101.2014.1000097", "pmid": "25590866", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00391", "slug": "lin-2015-the-adjuvant-effects-of", "title": "The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines.", "authors": "Lin, Chi-Chen; Pan, I-Hong; Li, Yi-Rong; Pan, Yi-Gen; Lin, Ming-Kuem; Lu, Yi-Huang; Wu, Hsin-Chieh; Chu, Ching-Liang", "year": 2015, "journal": "PloS one, 10(2), e0116191", "doi": "10.1371/journal.pone.0116191", "pmid": "25723174", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00392", "slug": "lin-2015-genotoxic-teratotoxic-and-oral", "title": "Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®).", "authors": "Lin, Chin-Chung; Kumar, K J Senthil; Liao, Jiunn-Wang; Kuo, Yueh-Hsiung; Wang, Sheng-Yang", "year": 2015, "journal": "Toxicology reports, 2, 1409-1417", "doi": "10.1016/j.toxrep.2015.10.007", "pmid": "28962482", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00393", "slug": "lin-2015-the-ethanolic-extract-of", "title": "The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells.", "authors": "Lin, Liang-Tzung; Tai, Chen-Jei; Su, Ching-Hua; Chang, Fang-Mo; Choong, Chen-Yen; Wang, Chien-Kai; Tai, Cheng-Jeng", "year": 2015, "journal": "BioMed research international, 2015, 415269", "doi": "10.1155/2015/415269", "pmid": "26557666", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00394", "slug": "liu-2015-study-of-heavy-metal", "title": "Study of heavy metal concentrations in wild edible mushrooms in Yunnan Province, China.", "authors": "Liu, Borui; Huang, Qing; Cai, Huajie; Guo, Xiang; Wang, Tingting; Gui, Mingying", "year": 2015, "journal": "Food chemistry, 188, 294-300", "doi": "10.1016/j.foodchem.2015.05.010", "pmid": "26041195", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00395", "slug": "liu-2015-polysaccharide-agaricus-blazei-murill", "title": "Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway.", "authors": "Liu, Yi; Zhang, Lingyun; Zhu, Xiangxiang; Wang, Yuehua; Liu, WenWei; Gong, Wei", "year": 2015, "journal": "Immunology, 146(3), 379-91", "doi": "10.1111/imm.12508", "pmid": "26194418", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00396", "slug": "ma-2015-cordycepin-from-cordyceps-militaris", "title": "Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice.", "authors": "Ma, Li; Zhang, Song; Du, Mei", "year": 2015, "journal": "Nutrition research (New York, N.Y.), 35(5), 431-9", "doi": "10.1016/j.nutres.2015.04.011", "pmid": "25940982", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00397", "slug": "phan-2015-therapeutic-potential-of-culinarymedicinal", "title": "Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism.", "authors": "Phan, Chia-Wei; David, Pamela; Naidu, Murali; Wong, Kah-Hui; 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Hossain, Md Akil; Damte, Dereje; Jo, Woo-Sik; Hsu, Walter H; Park, Seung-Chun", "year": 2015, "journal": "International journal of medicinal mushrooms, 17(8), 723-34", "doi": null, "pmid": "26559859", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00400", "slug": "socala-2015-evaluation-of-anticonvulsant-antidepressant", "title": "Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice.", "authors": "Socala, Katarzyna; Nieoczym, Dorota; Grzywnowicz, Krzysztof; Stefaniuk, Dawid; Wlaz, Piotr", "year": 2015, "journal": "International journal of medicinal mushrooms, 17(3), 209-18", "doi": null, "pmid": "25954905", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00401", "slug": "song-2015-studies-on-the-antifatigue", "title": "Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model.", "authors": "Song, Jingjing; 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Qian, Yi; Li, Zi-Wei; Tzeng, Yew-Min; Zhou, De-Min; Guo, De-An; Ye, Min", "year": 2015, "journal": "Natural products and bioprospecting, 5(5), 237-46", "doi": "10.1007/s13659-015-0072-4", "pmid": "26411834", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00410", "slug": "xiao-2015-hypoglycemic-effects-of-grifola", "title": "Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.", "authors": "Xiao, Chun; Wu, Qingping; Xie, Yizhen; Zhang, Jumei; Tan, Jianbin", "year": 2015, "journal": "Food & function, 6(11), 3567-75", "doi": "10.1039/c5fo00497g", "pmid": "26311233", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00411", "slug": "yang-2015-cordycepin-alleviates-airway-hyperreactivity", "title": "Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process.", "authors": "Yang, Xiaofeng; 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Qiu, Xue-Hong; Han, Ri-Chou", "year": 2015, "journal": "Mycobiology, 43(1), 37-42", "doi": "10.5941/MYCO.2015.43.1.37", "pmid": "25892913", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00414", "slug": "zhou-2015-hypoglycemic-activity-of-polysaccharide", "title": "Hypoglycemic Activity of Polysaccharide from Fruiting Bodies of the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes), on Mice Induced by Alloxan and Its Potential Mechanism.", "authors": "Zhou, Shuai; Liu, Yanfang; Yang, Yan; Tang, Qingjiu; Zhang, Jingsong", "year": 2015, "journal": "International journal of medicinal mushrooms, 17(10), 957-64", "doi": null, "pmid": "26756187", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00415", "slug": "zhuk-2015-research-on-acute-toxicity", "title": "Research on acute toxicity and the behavioral effects of methanolic extract from psilocybin mushrooms and psilocin in mice.", "authors": "Zhuk, Olga; 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Bensoussan, Alan; Steiner, Genevieve Z; Chang, Dennis H", "year": 2016, "journal": "Scientific reports, 6, 29540", "doi": "10.1038/srep29540", "pmid": "27511742", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00430", "slug": "kuo-2016-antcin-k-a-triterpenoid", "title": "Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles.", "authors": "Kuo, Yueh-Hsiung; Lin, Cheng-Hsiu; Shih, Chun-Ching; Yang, Chang-Syun", "year": 2016, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2016, 4867092", "doi": "10.1155/2016/4867092", "pmid": "27242912", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00431", "slug": "kuo-2016-dehydroeburicoic-acid-from-antrodia", "title": "Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice.", "authors": "Kuo, Yueh-Hsiung; 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Tseng, Hisa Hui Ling; Kwan, Yiu Wa; Lee, Simon Ming-Yuen; Hoi, Maggie Pui Man", "year": 2016, "journal": "Frontiers in pharmacology, 7, 67", "doi": "10.3389/fphar.2016.00067", "pmid": "27047382", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00455", "slug": "wang-2016-diversity-and-effect-of", "title": "Diversity and effect of Trichoderma spp. associated with green mold disease on Lentinula edodes in China.", "authors": "Wang, Gangzheng; Cao, Xiantao; Ma, Xiaolong; Guo, Mengpei; Liu, Changhao; Yan, Lianlian; Bian, Yinbing", "year": 2016, "journal": "MicrobiologyOpen, 5(4), 709-18", "doi": "10.1002/mbo3.364", "pmid": "27147196", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00456", "slug": "wang-2016-herbal-medicine-cordyceps-sinensis", "title": "Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma.", "authors": "Wang, Ningqun; Li, Jie; Huang, Xiaobo; Chen, Wenqiang; Chen, Yujing", "year": 2016, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2016, 6134593", "doi": "10.1155/2016/6134593", "pmid": "28050193", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00457", "slug": "xu-2016-antioxidant-activity-in-vitro", "title": "Antioxidant activity in vitro and in vivo of the polysaccharides from different varieties of Auricularia auricula.", "authors": "Xu, Siqi; Zhang, Yongjun; Jiang, Kan", "year": 2016, "journal": "Food & function, 7(9), 3868-79", "doi": "10.1039/c6fo00686h", "pmid": "27506886", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00458", "slug": "yu-2016-cordyceps-militaris-treatment-preserves", "title": "Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice.", "authors": "Yu, Sung-Hsun; Dubey, Navneet Kumar; Li, Wei-Shan; Liu, Ming-Che; Chiang, Han-Sun; Leu, Sy-Jye; Shieh, Ying-Hua; 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Griffiths, Roland R", "year": 2017, "journal": "Personality and individual differences, 117, 155-160", "doi": "10.1016/j.paid.2017.06.004", "pmid": "28781400", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00461", "slug": "brown-2017-pharmacokinetics-of-escalating-doses", "title": "Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults.", "authors": "Brown, Randall T; Nicholas, Christopher R; Cozzi, Nicholas V; Gassman, Michele C; Cooper, Karen M; Muller, Daniel; Thomas, Chantelle D; Hetzel, Scott J; Henriquez, Kelsey M; Ribaudo, Alexandra S; Hutson, Paul R", "year": 2017, "journal": "Clinical pharmacokinetics, 56(12), 1543-1554", "doi": "10.1007/s40262-017-0540-6", "pmid": "28353056", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00462", "slug": "cai-2017-polysaccharides-from-ganoderma-lucidum", "title": "Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.", "authors": "Cai, Qing; Li, Yuanyuan; Pei, Gang", "year": 2017, "journal": "Journal of neuroinflammation, 14(1), 63", "doi": "10.1186/s12974-017-0839-0", "pmid": "28340576", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00463", "slug": "carhart-harris-2017-psilocybin-for-treatmentresistant-depression", "title": "Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms.", "authors": "Carhart-Harris, Robin L; Roseman, Leor; Bolstridge, Mark; Demetriou, Lysia; Pannekoek, J Nienke; Wall, Matthew B; Tanner, Mark; Kaelen, Mendel; McGonigle, John; Murphy, Kevin; Leech, Robert; Curran, H Valerie; Nutt, David J", "year": 2017, "journal": "Scientific reports, 7(1), 13187", "doi": "10.1038/s41598-017-13282-7", "pmid": "29030624", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00464", "slug": "chang-2017-effects-of-antrosterol-from", "title": "Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice.", "authors": "Chang, Yuan-Yen; Liu, Yi-Chen; Kuo, Yueh-Hsiung; Lin, Yi-Ling; Wu, Yi-Hsieng Samuel; Chen, Jr-Wei; Chen, Yi-Chen", "year": 2017, "journal": "Journal of ethnopharmacology, 202, 200-207", "doi": "10.1016/j.jep.2017.03.003", "pmid": "28274894", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00465", "slug": "chen-2017-dglucan-from-antrodia-camphorata", "title": "β-d-glucan from Antrodia Camphorata ameliorates LPS-induced inflammation and ROS production in human hepatocytes.", "authors": "Chen, Qiuli; Tang, Huiling; Zha, Zhengqi; Yin, Hongping; Wang, Ying; Wang, Yufeng; Li, Haitao; Yue, Long", "year": 2017, "journal": "International journal of biological macromolecules, 104(Pt A), 768-777", "doi": "10.1016/j.ijbiomac.2017.05.191", "pmid": "28642114", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00466", "slug": "chen-2017-functional-study-of-cordyceps", "title": "Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review.", "authors": "Chen, Yung-Chia; Chen, Ying-Hui; Pan, Bo-Syong; Chang, Ming-Min; Huang, Bu-Miin", "year": 2017, "journal": "Journal of food and drug analysis, 25(1), 197-205", "doi": "10.1016/j.jfda.2016.10.020", "pmid": "28911537", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00467", "slug": "chiu-2017-antcinh-isolated-from-antrodia", "title": "Antcin-H Isolated from Antrodia cinnamomea Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-β/c-Fos-MMP-7 Pathways.", "authors": "Chiu, Kun-Yuan; Chen, Tzu-Hsiu; Wen, Chi-Luan; Lai, Jin-Mei; Cheng, Chi-Chih; Liu, Hsiang-Chun; Hsu, Shih-Lan; Tzeng, Yew-Min", "year": 2017, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2017, 5052870", "doi": "10.1155/2017/5052870", "pmid": "29234409", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00468", "slug": "da-2017-agaricus-blazei-bioactive-compounds", "title": "Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies.", "authors": "da Silva de Souza, Aline Cristine; Correa, Vanesa Gesser; Goncalves, Geferson de Almeida; Soares, Andreia Assuncao; Bracht, Adelar; Peralta, Rosane Marina", "year": 2017, "journal": "Current pharmaceutical design, 23(19), 2807-2834", "doi": "10.2174/1381612823666170119093719", "pmid": "28103773", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00469", "slug": "da-2017-agaricus-blazei-bioactive-compounds-2", "title": "Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies.", "authors": "da Silva de Souza, Aline Cristine; Correa, Vanesa Gesser; Goncalves, Geferson de Almeida; Soares, Andreia Assuncao; Bracht, Adelar; Peralta, Rosane Marina", "year": 2017, "journal": "Current pharmaceutical design, 23(19), 2807-2834", "doi": "10.2174/1381612823666170119093719", "pmid": "28103773", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00470", "slug": "diling-2017-extracts-from-hericium-erinaceus", "title": "Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota.", "authors": "Diling, Chen; Xin, Yang; Chaoqun, Zheng; Jian, Yang; Xiaocui, Tang; Jun, Chen; Ou, Shuai; Yizhen, Xie", "year": 2017, "journal": "Oncotarget, 8(49), 85838-85857", "doi": "10.18632/oncotarget.20689", "pmid": "29156761", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00471", "slug": "fricke-2017-enzymatic-synthesis-of-psilocybin", "title": "Enzymatic Synthesis of Psilocybin.", "authors": "Fricke, Janis; Blei, Felix; Hoffmeister, Dirk", "year": 2017, "journal": "Angewandte Chemie (International ed. in English), 56(40), 12352-12355", "doi": "10.1002/anie.201705489", "pmid": "28763571", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00472", "slug": "he-2017-structures-biological-activities-and", "title": "Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review.", "authors": "He, Xirui; Wang, Xiaoxiao; Fang, Jiacheng; Chang, Yu; Ning, Ning; Guo, Hao; Huang, Linhong; Huang, Xiaoqiang; Zhao, Zefeng", "year": 2017, "journal": "International journal of biological macromolecules, 97, 228-237", "doi": "10.1016/j.ijbiomac.2017.01.040", "pmid": "28087447", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00473", "slug": "hirsch-2017-cordyceps-militaris-improves-tolerance", "title": "Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation.", "authors": "Hirsch, Katie R; Smith-Ryan, Abbie E; Roelofs, Erica J; Trexler, Eric T; Mock, Meredith G", "year": 2017, "journal": "Journal of dietary supplements, 14(1), 42-53", "doi": "10.1080/19390211.2016.1203386", "pmid": "27408987", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00474", "slug": "hu-2017-hpyerglycemic-and-antidiabetic-nephritis", "title": "Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats.", "authors": "Hu, Xinyu; 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Jiang, Guohong; Yang, Jingbo; Liu, Jizhang; Zhao, Lijie; Ma, Peilong", "year": 2019, "journal": "Oxidative medicine and cellular longevity, 2019, 7850863", "doi": "10.1155/2019/7850863", "pmid": "31049139", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00589", "slug": "sun-2019-domestic-cooking-methods-affect", "title": "Domestic cooking methods affect nutrient, phytochemicals, and flavor content in mushroom soup.", "authors": "Sun, Yujing; Lv, Feiyan; Tian, Jinhu; Ye, Xing Qian; Chen, Jianchu; Sun, Peilong", "year": 2019, "journal": "Food science & nutrition, 7(6), 1969-1975", "doi": "10.1002/fsn3.996", "pmid": "31289644", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00590", "slug": "vigna-2019-hericium-erinaceus-improves-mood", "title": "Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?", "authors": "Vigna, Luisella; 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Dziendzikowska, Katarzyna; Gajewska, Małgorzata; Wilczak, Jacek; Harasym, Joanna; Gromadzka-Ostrowska, Joanna", "year": 2019, "journal": "Molecules (Basel, Switzerland), 24(19)", "doi": "10.3390/molecules24193591", "pmid": "31590413", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00604", "slug": "almeida-2020-toucan-a-framework-for", "title": "TOUCAN: a framework for fungal biosynthetic gene cluster discovery.", "authors": "Almeida, Hayda; Palys, Sylvester; Tsang, Adrian; Diallo, Abdoulaye Baniré", "year": 2020, "journal": "NAR genomics and bioinformatics, 2(4), lqaa098", "doi": "10.1093/nargab/lqaa098", "pmid": "33575642", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00605", "slug": "ashraf-2020-cordycepin-for-health-and", "title": "Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential.", "authors": "Ashraf, Syed Amir; Elkhalifa, Abd Elmoneim O; Siddiqui, Arif Jamal; Patel, Mitesh; Awadelkareem, Amir Mahgoub; Snoussi, Mejdi; Ashraf, Mohammad Saquib; Adnan, Mohd; Hadi, Sibte", "year": 2020, "journal": "Molecules (Basel, Switzerland), 25(12)", "doi": "10.3390/molecules25122735", "pmid": "32545666", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00606", "slug": "bai-2020-the-protective-effect-of", "title": "The protective effect of cordyceps sinensis extract on cerebral ischemic injury via modulating the mitochondrial respiratory chain and inhibiting the mitochondrial apoptotic pathway.", "authors": "Bai, Xue; Tan, Tian-Yang; Li, Yun-Xin; Li, Yue; Chen, Ya-Fei; Ma, Ru; Wang, Shu-Yan; Li, Qiang; Liu, Zhen-Quan", "year": 2020, "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 124, 109834", "doi": "10.1016/j.biopha.2020.109834", "pmid": "31978767", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00607", "slug": "bao-2020-isolation-purification-characterization-and", "title": "Isolation, purification, characterization, and immunomodulatory effects of polysaccharide from Auricularia auricula on RAW264.7 macrophages.", "authors": "Bao, Zhijie; Yao, Liqun; Zhang, Xiyue; Lin, Songyi", "year": 2020, "journal": "Journal of food biochemistry, 44(12), e13516", "doi": "10.1111/jfbc.13516", "pmid": "33051900", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00608", "slug": "barrett-2020-psilocybin-acutely-alters-the", "title": "Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.", "authors": "Barrett, Frederick S; Krimmel, Samuel R; Griffiths, Roland R; Seminowicz, David A; Mathur, Brian N", "year": 2020, "journal": "NeuroImage, 218, 116980", "doi": "10.1016/j.neuroimage.2020.116980", "pmid": "32454209", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00609", "slug": "bian-2020-extraction-optimization-structural-characterization", "title": "Extraction Optimization, Structural Characterization, and Anticoagulant Activity of Acidic Polysaccharides from Auricularia auricula-judae.", "authors": "Bian, Chun; Wang, ZhenYu; Shi, John", "year": 2020, "journal": "Molecules (Basel, Switzerland), 25(3)", "doi": "10.3390/molecules25030710", "pmid": "32041370", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00610", "slug": "blumfield-2020-examining-the-health-effects", "title": "Examining the health effects and bioactive components in Agaricus bisporus mushrooms: a scoping review.", "authors": "Blumfield, Michelle; Abbott, Kylie; Duve, Emily; Cassettari, Tim; Marshall, Skye; Fayet-Moore, Flavia", "year": 2020, "journal": "The Journal of nutritional biochemistry, 84, 108453", "doi": "10.1016/j.jnutbio.2020.108453", "pmid": "32653808", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00611", "slug": "chen-2020-polysaccharides-from-auricularia-auricula", "title": "Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities.", "authors": "Chen, Nana; Zhang, Hao; Zong, Xin; Li, Siyu; Wang, Jiaojiao; Wang, Yizhen; Jin, Mingliang", "year": 2020, "journal": "Carbohydrate polymers, 247, 116750", "doi": "10.1016/j.carbpol.2020.116750", "pmid": "32829866", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00612", "slug": "chen-2020-a-pilot-study-to", "title": "A Pilot Study to Assess Food Safety and Potential Cholesterol-Lowering Efficacy of Antrodia cinnamomea Solid-State Cultivated Mycelium in Healthy Adults.", "authors": "Chen, Wan-Jing; Chang, Fung-Wei", "year": 2020, "journal": "Evidence-based complementary and alternative medicine : eCAM, 2020, 5865764", "doi": "10.1155/2020/5865764", "pmid": "32351598", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00613", "slug": "choi-2020-beneficial-effect-of-cordyceps", "title": "Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production.", "authors": "Choi, Eunhyun; Oh, Junsang; Sung, Gi-Ho", "year": 2020, "journal": "Mycobiology, 48(6), 512-517", "doi": "10.1080/12298093.2020.1831135", "pmid": "33312018", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00614", "slug": "dicks-2020-effect-of-the-intake", "title": "Effect of the Intake of Oyster Mushrooms (Pleurotus ostreatus) on Cardiometabolic Parameters-A Systematic Review of Clinical Trials.", "authors": "Dicks, Lisa; Ellinger, Sabine", "year": 2020, "journal": "Nutrients, 12(4)", "doi": "10.3390/nu12041134", "pmid": "32316680", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00615", "slug": "gunnels-2020-the-its-region-provides", "title": "The ITS region provides a reliable DNA barcode for identifying reishi/lingzhi (Ganoderma) from herbal supplements.", "authors": "Gunnels, Tess; Creswell, Matthew; McFerrin, Janis; Whittall, Justen B", "year": 2020, "journal": "PloS one, 15(11), e0236774", "doi": "10.1371/journal.pone.0236774", "pmid": "33180770", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00616", "slug": "han-2020-antrodia-camphorata-polysaccharide-resists", "title": "Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.", "authors": "Han, Chenyang; Shen, Heping; Yang, Yi; Sheng, Yongjia; Wang, Jin; Li, Wenyan; Zhou, Xiaohong; Guo, Li; Zhai, Liping; Guan, Qiaobing", "year": 2020, "journal": "Brain and behavior, 10(11), e01824", "doi": "10.1002/brb3.1824", "pmid": "32902155", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00617", "slug": "han-2020-cordycepin-protects-renal-ischemiareperfusion", "title": "Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress.", "authors": "Han, Feng; Dou, Meng; Wang, Yuxiang; Xu, Cuixiang; Li, Yang; Ding, XiaoMing; Xue, WuJun; Zheng, Jin; Tian, Puxun; Ding, Chenguang", "year": 2020, "journal": "Acta biochimica et biophysica Sinica, 52(2), 125-132", "doi": "10.1093/abbs/gmz145", "pmid": "31951250", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00618", "slug": "hawley-2020-mechanism-of-activation-of", "title": "Mechanism of Activation of AMPK by Cordycepin.", "authors": "Hawley, Simon A; Ross, Fiona A; Russell, Fiona M; Atrih, Abdelmadjid; Lamont, Douglas J; Hardie, D Grahame", "year": 2020, "journal": "Cell chemical biology, 27(2), 214-222.e4", "doi": "10.1016/j.chembiol.2020.01.004", "pmid": "31991096", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00619", "slug": "he-2020-cordyceps-sinensis-attenuates-hbxinduced", "title": "Cordyceps sinensis attenuates HBx‑induced cell apoptosis in HK‑2 cells through suppressing the PI3K/Akt pathway.", "authors": "He, Ping; Lei, Jing; Miao, Jia-Ning; Wu, Di; Wang, Cheng", "year": 2020, "journal": "International journal of molecular medicine, 45(4), 1261-1269", "doi": "10.3892/ijmm.2020.4503", "pmid": "32124952", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00620", "slug": "hetland-2020-antitumor-antiinflammatory-and-antiallergic", "title": "Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies.", "authors": "Hetland, Geir; Tangen, Jon-Magnus; Mahmood, Faiza; Mirlashari, Mohammad Reza; Nissen-Meyer, Lise Sofie Haug; Nentwich, Ivo; Therkelsen, Stig Palm; Tjønnfjord, Geir Erland; Johnson, Egil", "year": 2020, "journal": "Nutrients, 12(5)", "doi": "10.3390/nu12051339", "pmid": "32397163", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00621", "slug": "hu-2020-ultraviolet-irradiation-increased-the", "title": "Ultraviolet Irradiation Increased the Concentration of Vitamin D2 and Decreased the Concentration of Ergosterol in Shiitake Mushroom (Lentinus edodes) and Oyster Mushroom (Pleurotus ostreatus) Powder in Ethanol Suspension.", "authors": "Hu, Daihua; Chen, Wang; Li, Xinsheng; Yue, Tianli; Zhang, Zhijian; Feng, Zili; Li, Cuili; Bu, Xing; Li, Qing X; Hu, Ching Y; Li, LiuDi", "year": 2020, "journal": "ACS omega, 5(13), 7361-7368", "doi": "10.1021/acsomega.9b04321", "pmid": "32280877", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00622", "slug": "jeitler-2020-significance-of-medicinal-mushrooms", "title": "Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.", "authors": "Jeitler, Michael; Michalsen, Andreas; Frings, Daniela; Hübner, Marisa; Fischer, Moritz; Koppold-Liebscher, Daniela A; Murthy, Vijay; Kessler, Christian S", "year": 2020, "journal": "Frontiers in pharmacology, 11, 580656", "doi": "10.3389/fphar.2020.580656", "pmid": "33424591", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00623", "slug": "jiang-2020-uv-induced-conversion-during", "title": "UV induced conversion during drying of ergosterol to vitamin D in various mushrooms: Effect of different drying conditions.", "authors": "Jiang, Qiyong; Zhang, Min; Mujumdar, Arun S", "year": 2020, "journal": "Trends in food science & technology, 105, 200-210", "doi": "10.1016/j.tifs.2020.09.011", "pmid": "32982063", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00624", "slug": "kang-2020-auricularia-auricula-increases-an", "title": "Auricularia auricula increases an apoptosis in human hepatocellular carcinoma cells via a regulation of the peroxiredoxin1.", "authors": "Kang, Mi Ae; Jeon, Young Keul; Nam, Myeong Jin", "year": 2020, "journal": "Journal of food biochemistry, 44(10), e13373", "doi": "10.1111/jfbc.13373", "pmid": "32743825", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00625", "slug": "kanno-2020-quantification-of-glucan-from", "title": "Quantification of β-Glucan from Culinary-Medicinal Mushrooms Using Novel Artificial β-Glucan Recognition Protein.", "authors": "Kanno, Takashi; Adachi, Yoshiyuki; Ishibashi, Ken-Ichi; Yamanaka, Daisuke; Ohno, Naohito", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(3), 269-276", "doi": "10.1615/IntJMedMushrooms.2020034003", "pmid": "32479021", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-00626", "slug": "kayode-2020-mushroom-allergy-case-series", "title": "Mushroom allergy: Case series.", "authors": "Kayode, Oyindamola Stephanie; Siew, Leonard Quok Chean; Pillai, Prathap; Haque, Rubaiyat; Rutkowski, Krzysztof; Caballero, Maria Rosario", "year": 2020, "journal": "The journal of allergy and clinical immunology. 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Cortes, Hernán; Singh, Yengkhom Disco; Panda, Manasa Kumar; Mishra, Abhay Prakash; Nigam, Manisha; Saklani, Sarla; Chaturi, Praveen Kumar; Martorell, Miquel; Cruz-Martins, Natália; Sharma, Vineet; Garg, Neha; Sharma, Rohit; Patra, Jayanta Kumar", "year": 2020, "journal": "Frontiers in pharmacology, 11, 602364", "doi": "10.3389/fphar.2020.602364", "pmid": "33628175", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01185", "slug": "diallo-2020-antioxidant-and-antiinflammatory-potential", "title": "Antioxidant and Anti-Inflammatory Potential of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Sporophores from Various Culture Conditions.", "authors": "Diallo, Ibrahima; Boudard, Frédéric; Morel, Sylvie; Vitou, Manon; Guzman, Caroline; Saint, Nathalie; Michel, Alain; Rapior, Sylvie; Traoré, Lonsény; Poucheret, Patrick; Fons, Françoise", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(6), 535-546", "doi": "10.1615/IntJMedMushrooms.2020034864", "pmid": "32865895", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01186", "slug": "RTHM-01186", "title": "Effect of the Intake of Oyster Mushrooms (Pleurotus ostreatus) on Cardiometabolic Parameters-A Systematic Review of Clinical Trials.", "authors": "Dicks, Lisa; 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Deng, Jia-Cong; Pan, Yu-Yang; Xu, Jia-Xin; Hong, Jia-Li; Shi, Fei-Fei; Liu, Gong-Liang; Qian, Min; Bai, Wei-Dong; Zhang, Wen; Liu, Bin; Zhang, Yan-Yan; Luo, Peng-Jie; Ni, Li; Rao, Ping-Fan; Lv, Xu-Cong", "year": 2020, "journal": "International journal of biological macromolecules, 153, 1231-1240", "doi": "10.1016/j.ijbiomac.2019.10.253", "pmid": "31759027", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01194", "slug": "habtemariam-2020-trametes-versicolor-synn-coriolus", "title": "Trametes versicolor (Synn. 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Shojaosadati, Seyed Abbas; Najafi, Vahid; Alizadeh, Vahid", "year": 2020, "journal": "Carbohydrate polymers, 229, 115383", "doi": "10.1016/j.carbpol.2019.115383", "pmid": "31826529", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01197", "slug": "RTHM-01197", "title": "Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.", "authors": "Han, Chenyang; Shen, Heping; Yang, Yi; Sheng, Yongjia; Wang, Jin; Li, Wenyan; Zhou, Xiaohong; Guo, Li; Zhai, Liping; Guan, Qiaobing", "year": 2020, "journal": "Brain and behavior, 10(11), e01824", "doi": "10.1002/brb3.1824", "pmid": "32902155", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01198", "slug": "RTHM-01198", "title": "Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress.", "authors": "Han, Feng; Dou, Meng; Wang, Yuxiang; Xu, Cuixiang; Li, Yang; Ding, XiaoMing; Xue, WuJun; Zheng, Jin; Tian, Puxun; Ding, Chenguang", "year": 2020, "journal": "Acta biochimica et biophysica Sinica, 52(2), 125-132", "doi": "10.1093/abbs/gmz145", "pmid": "31951250", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01199", "slug": "RTHM-01199", "title": "Mechanism of Activation of AMPK by Cordycepin.", "authors": "Hawley, Simon A; Ross, Fiona A; Russell, Fiona M; Atrih, Abdelmadjid; Lamont, Douglas J; Hardie, D Grahame", "year": 2020, "journal": "Cell chemical biology, 27(2), 214-222.e4", "doi": "10.1016/j.chembiol.2020.01.004", "pmid": "31991096", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01200", "slug": "RTHM-01200", "title": "Cordyceps sinensis attenuates HBx‑induced cell apoptosis in HK‑2 cells through suppressing the PI3K/Akt pathway.", "authors": "He, Ping; Lei, Jing; Miao, Jia-Ning; Wu, Di; Wang, Cheng", "year": 2020, "journal": "International journal of molecular medicine, 45(4), 1261-1269", "doi": "10.3892/ijmm.2020.4503", "pmid": "32124952", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01201", "slug": "RTHM-01201", "title": "Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies.", "authors": "Hetland, Geir; 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Chen, Wang; Li, Xinsheng; Yue, Tianli; Zhang, Zhijian; Feng, Zili; Li, Cuili; Bu, Xing; Li, Qing X; Hu, Ching Y; Li, LiuDi", "year": 2020, "journal": "ACS omega, 5(13), 7361-7368", "doi": "10.1021/acsomega.9b04321", "pmid": "32280877", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01204", "slug": "huang-2020-poria-cocos-water-extract", "title": "Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation.", "authors": "Huang, Yun-Ju; Hsu, Nai-Yuan; Lu, Kuan-Hung; Lin, Yu-En; Lin, Shih-Hang; Lu, Yun-Sheng; Liu, Wei-Ting; Chen, Mei-Hsing; Sheen, Lee-Yan", "year": 2020, "journal": "Journal of ethnopharmacology, 258, 112566", "doi": "10.1016/j.jep.2020.112566", "pmid": "31926986", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01205", "slug": "huo-2020-polysaccharide-from-wild-morels", "title": "Polysaccharide from wild morels alters the spatial structure of gut microbiota and the production of short-chain fatty acids in mice.", "authors": "Huo, Wenyan; 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Pawlikowska, Małgorzata; Sobocińska, Justyna; Wrotek, Sylwia", "year": 2020, "journal": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(4), 615-628", "doi": "10.33594/000000244", "pmid": "32559360", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01210", "slug": "RTHM-01210", "title": "Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.", "authors": "Jeitler, Michael; Michalsen, Andreas; Frings, Daniela; Hübner, Marisa; Fischer, Moritz; Koppold-Liebscher, Daniela A; Murthy, Vijay; Kessler, Christian S", "year": 2020, "journal": "Frontiers in pharmacology, 11, 580656", "doi": "10.3389/fphar.2020.580656", "pmid": "33424591", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01211", "slug": "RTHM-01211", "title": "UV induced conversion during drying of ergosterol to vitamin D in various mushrooms: Effect of different drying conditions.", "authors": "Jiang, Qiyong; Zhang, Min; Mujumdar, Arun S", "year": 2020, "journal": "Trends in food science & technology, 105, 200-210", "doi": "10.1016/j.tifs.2020.09.011", "pmid": "32982063", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01212", "slug": "jiang-2020-adjuvant-therapy-with-mushroom", "title": "Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications.", "authors": "Jiang, Xue; Meng, Weiqi; Li, Lanzhou; Meng, Zhaoli; Wang, Di", "year": 2020, "journal": "Frontiers in pharmacology, 11, 168", "doi": "10.3389/fphar.2020.00168", "pmid": "32180724", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01213", "slug": "jin-2020-effect-of-cultivating-pleurotus", "title": "Effect of cultivating Pleurotus ostreatus on substrates supplemented with herb residues on yield characteristics, substrates degradation, and fruiting bodies' properties.", "authors": "Jin, Zhiqiang; Hou, Qinwen; Niu, Tianzeng", "year": 2020, "journal": "Journal of the science of food and agriculture, 100(13), 4901-4910", "doi": "10.1002/jsfa.10551", "pmid": "32478436", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01214", "slug": "RTHM-01214", "title": "Auricularia auricula increases an apoptosis in human hepatocellular carcinoma cells via a regulation of the peroxiredoxin1.", "authors": "Kang, Mi Ae; Jeon, Young Keul; Nam, Myeong Jin", "year": 2020, "journal": "Journal of food biochemistry, 44(10), e13373", "doi": "10.1111/jfbc.13373", "pmid": "32743825", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01215", "slug": "RTHM-01215", "title": "Quantification of β-Glucan from Culinary-Medicinal Mushrooms Using Novel Artificial β-Glucan Recognition Protein.", "authors": "Kanno, Takashi; Adachi, Yoshiyuki; Ishibashi, Ken-Ichi; Yamanaka, Daisuke; Ohno, Naohito", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(3), 269-276", "doi": "10.1615/IntJMedMushrooms.2020034003", "pmid": "32479021", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01216", "slug": "katrolia-2020-gene-cloning-expression-and", "title": "Gene cloning, expression and homology modeling of first fibrinolytic enzyme from mushroom (Cordyceps militaris).", "authors": "Katrolia, Priti; Liu, Xiaolan; Zhao, Yiyu; Kopparapu, Narasimha Kumar; Zheng, Xiqun", "year": 2020, "journal": "International journal of biological macromolecules, 146, 897-906", "doi": "10.1016/j.ijbiomac.2019.09.212", "pmid": "31726136", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01217", "slug": "RTHM-01217", "title": "Mushroom allergy: Case series.", "authors": "Kayode, Oyindamola Stephanie; Siew, Leonard Quok Chean; Pillai, Prathap; Haque, Rubaiyat; Rutkowski, Krzysztof; Caballero, Maria Rosario", "year": 2020, "journal": "The journal of allergy and clinical immunology. 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Tang, Xiaoxian; Duan, Zhenhua", "year": 2020, "journal": "Frontiers in immunology, 11, 595700", "doi": "10.3389/fimmu.2020.595700", "pmid": "33240285", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01222", "slug": "konno-2020-sxfraction-promise-for-novel", "title": "SX-fraction: Promise for novel treatment of type 2 diabetes.", "authors": "Konno, Sensuke", "year": 2020, "journal": "World journal of diabetes, 11(12), 572-583", "doi": "10.4239/wjd.v11.i12.572", "pmid": "33384765", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01223", "slug": "RTHM-01223", "title": "Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy.", "authors": "Kusama, Kazuya; Miyagawa, Mayuko; Ota, Koichiro; Kuwabara, Naoko; Saeki, Kaori; Ohnishi, Yuki; Kumaki, Yasuhiro; Aizawa, Tomoyasu; Nakasone, Toyokazu; Okamatsu, Shigemi; Miyaoka, Hiroaki; Tamura, Kazuhiro", "year": 2020, "journal": "Nutrients, 13(1)", "doi": "10.3390/nu13010050", "pmid": "33375244", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01224", "slug": "kushairi-2020-comparative-neuroprotective-antiinflammatory-and", "title": "Comparative Neuroprotective, Anti-Inflammatory and Neurite Outgrowth Activities of Extracts of King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes).", "authors": "Kushairi, Naufal; Phan, Chia-Wei; Sabaratnam, Vikineswary; Vidyadaran, Sharmili; Naidu, Murali; David, Pamela", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(12), 1171-1181", "doi": "10.1615/IntJMedMushrooms.2020036938", "pmid": "33463934", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01225", "slug": "lam-2020-herbdrug-interactions-between-the", "title": "Herb-drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review.", "authors": "Lam, Chun Sing; Cheng, Lok Pui; Zhou, Li Min; Cheung, Yin Ting; Zuo, Zhong", "year": 2020, "journal": "Chinese medicine, 15, 75", "doi": "10.1186/s13020-020-00356-4", "pmid": "32724333", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01226", "slug": "lee-2020-trends-in-the-immunomodulatory", "title": "Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin.", "authors": "Lee, Chun-Ting; Huang, Keng-Shiang; Shaw, Jei-Fu; Chen, Jung-Ren; Kuo, Wen-Shuo; Shen, Gangxu; Grumezescu, Alexandru Mihai; Holban, Alina Maria; Wang, Yi-Ting; Wang, Jun-Sheng; Hsiang, Yi-Ping; Lin, Yu-Mei; Hsu, Hsiao-Han; Yang, Chih-Hui", "year": 2020, "journal": "Frontiers in pharmacology, 11, 575704", "doi": "10.3389/fphar.2020.575704", "pmid": "33328984", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01227", "slug": "lee-2020-dietary-schizophyllan-reduces-mitochondrial", "title": "Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice.", "authors": "Lee, Daeun; Kim, Ye-Ram; Kim, Jae-Sung; Kim, Donggyu; Kim, Sojin; Kim, Sun Young; Jang, Kiseok; Lee, Jong-Dae; Yang, Chul-Su", "year": 2020, "journal": "Archives of pharmacal research, 43(4), 449-461", "doi": "10.1007/s12272-020-01231-4", "pmid": "32236798", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01228", "slug": "lee-2020-ganoderma-lucidum-extract-reduces", "title": "Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.", "authors": "Lee, Hyeon A; Cho, Jae-Han; Afinanisa, Qonita; An, Gi-Hong; Han, Jae-Gu; Kang, Hyo Jeung; Choi, Seong Ho; Seong, Hyun-A", "year": 2020, "journal": "Nutrients, 12(11)", "doi": "10.3390/nu12113338", "pmid": "33142995", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01229", "slug": "lee-2020-posttreatment-with-erinacine-a", "title": "Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson's Disease.", "authors": "Lee, Kam-Fai; Tung, Shui-Yi; Teng, Chih-Chuan; Shen, Chien-Heng; Hsieh, Meng Chiao; Huang, Cheng-Yi; Lee, Ko-Chao; Lee, Li-Ya; Chen, Wan-Ping; Chen, Chin-Chu; Huang, Wen-Shih; Kuo, Hsing-Chun", "year": 2020, "journal": "Antioxidants (Basel, Switzerland), 9(2)", "doi": "10.3390/antiox9020137", "pmid": "32033220", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01230", "slug": "lee-2020-inflammatory-responses-of-macrophagelike", "title": "Inflammatory responses of macrophage-like RAW264.7 cells in a 3D hydrogel matrix to ultrasonicated schizophyllan.", "authors": "Lee, Sora; Ki, Chang Seok", "year": 2020, "journal": "Carbohydrate polymers, 229, 115555", "doi": "10.1016/j.carbpol.2019.115555", "pmid": "31826421", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01231", "slug": "RTHM-01231", "title": "Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literature.", "authors": "Lee, Sua; Lee, Hwa Young; Park, Yohan; Ko, Eun Jeong; Ban, Tae Hyun; Chung, Byung Ha; Lee, Hyun Soon; Yang, Chul Woo", "year": 2020, "journal": "Journal of Korean medical science, 35(19), e122", "doi": "10.3346/jkms.2020.35.e122", "pmid": "32419395", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01232", "slug": "lenz-2020-injurytriggered-blueing-reactions-of", "title": "Injury-Triggered Blueing Reactions of Psilocybe \"Magic\" Mushrooms.", "authors": "Lenz, Claudius; Wick, Jonas; Braga, Daniel; García-Altares, María; Lackner, Gerald; Hertweck, Christian; Gressler, Markus; Hoffmeister, Dirk", "year": 2020, "journal": "Angewandte Chemie (International ed. in English), 59(4), 1450-1454", "doi": "10.1002/anie.201910175", "pmid": "31725937", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01233", "slug": "lew-2020-neuroprotective-effects-of-hericium", "title": "Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells.", "authors": "Lew, Sze Yuen; Lim, Siew Huah; Lim, Lee Wei; Wong, Kah Hui", "year": 2020, "journal": "BMC complementary medicine and therapies, 20(1), 340", "doi": "10.1186/s12906-020-03132-x", "pmid": "33176761", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01234", "slug": "li-2020-ganoderma-lucidum-polysaccharides-ameliorates", "title": "Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.", "authors": "Li, Hong Ning; Zhao, Ling Li; Zhou, Di Yi; Chen, Dan Qing", "year": 2020, "journal": "Medical science monitor : international medical journal of experimental and clinical research, 26, e921905", "doi": "10.12659/MSM.921905", "pmid": "32245940", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01235", "slug": "RTHM-01235", "title": "Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study.", "authors": "Li, I-Chen; Chang, Han-Hsin; Lin, Chuan-Han; Chen, Wan-Ping; Lu, Tsung-Han; Lee, Li-Ya; Chen, Yu-Wen; Chen, Yen-Po; Chen, Chin-Chu; Lin, David Pei-Cheng", "year": 2020, "journal": "Frontiers in aging neuroscience, 12, 155", "doi": "10.3389/fnagi.2020.00155", "pmid": "32581767", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01236", "slug": "li-2020-effects-of-agaricus-blazei", "title": "Effects of Agaricus blazei Murrill polysaccharides on hyperlipidemic rats by regulation of intestinal microflora.", "authors": "Li, Yuxin; Lu, Xuechun; Li, Xiao; Guo, Xiao; Sheng, Yu; Li, Yingna; Xu, Guangyu; Han, Xiao; An, Liping; Du, Peige", "year": 2020, "journal": "Food science & nutrition, 8(6), 2758-2772", "doi": "10.1002/fsn3.1568", "pmid": "32566193", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01237", "slug": "liang-2020-effect-of-the-king", "title": "Effect of the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Basidiocarps Powder to Ameliorate Memory and Learning Deficit in Ability in Aβ-Induced Alzheimer's Disease C57BL/6J Mice Model.", "authors": "Liang, Chih-Hung; Huang, Po-Chang; Mau, Jeng-Leun; Chiang, Shen-Shih", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(2), 145-159", "doi": "10.1615/IntJMedMushrooms.2020033766", "pmid": "32479003", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01238", "slug": "liao-2020-cordycepin-reverses-cisplatin-resistance", "title": "Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway.", "authors": "Liao, Xiao-Zhong; Gao, Ying; Zhao, Hong-Wei; Zhou, Mi; Chen, Dan-Lei; Tao, Lan-Ting; Guo, Wei; Sun, Ling-Ling; Gu, Chu-Ying; Chen, Han-Rui; Xiao, Zhi-Wei; Zhang, Jia-Xing; He, Mei-Fang; Lin, Li-Zhu", "year": 2020, "journal": "Frontiers in cell and developmental biology, 8, 609285", "doi": "10.3389/fcell.2020.609285", "pmid": "33520990", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01239", "slug": "RTHM-01239", "title": "Medicinal Mushrooms for Treatment of Type 2 Diabetes: An Update on Clinical Trials.", "authors": "Lindequist, Ulrike; Haertel, Beate", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(9), 845-854", "doi": "10.1615/IntJMedMushrooms.2020035863", "pmid": "33389851", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01240", "slug": "liu-2020-preliminary-efficacy-and-safety", "title": "Preliminary Efficacy and Safety of Reishi & Privet Formula on Quality of Life Among Non-Small Cell Lung Cancer Patients Undergoing Chemotherapy: A Randomized Placebo-Controlled Trial.", "authors": "Liu, Jie; Mao, Jun J; Li, Susan Qing; Lin, Hongsheng", "year": 2020, "journal": "Integrative cancer therapies, 19, 1534735420944491", "doi": "10.1177/1534735420944491", "pmid": "32840126", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01241", "slug": "liu-2020-isolation-and-structural-characterization", "title": "Isolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of cell cycle at S-phage in colon cancer cells.", "authors": "Liu, Jing-Yu; Hou, Xiao-Xiao; Li, Zhuo-Yu; Shan, Shu-Hua; Chang, Ming-Chang; Feng, Cui-Ping; Wei, Yin", "year": 2020, "journal": "International journal of biological macromolecules, 157, 288-295", "doi": "10.1016/j.ijbiomac.2020.04.162", "pmid": "32339580", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01242", "slug": "liu-2020-a-review-on-linking", "title": "A Review on Linking the Medicinal Functions of Mushroom Prebiotics with Gut Microbiota.", "authors": "Liu, Xiaoxiao; Yu, Zihang; Jia, Wei; Wu, Yingying; Wu, Di; Zhang, Henan; Liu, Zhendong; Yang, Yan; Zhang, Jingsong; Liu, Yanfang; Tang, Chuanhong; Wang, Wenhan; Zhu, Lina", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(10), 943-951", "doi": "10.1615/IntJMedMushrooms.2020035799", "pmid": "33426824", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01243", "slug": "RTHM-01243", "title": "A Study on the Antioxidant Properties and Stability of Ergothioneine from Culinary-Medicinal Mushrooms.", "authors": "Liu, Xinqi; Huang, Yiwen; Wang, Jinyan; Zhou, Shuai; Wang, Yili; Cai, Mengting; Yu, Ling; Tang, Qingjiu", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(3), 211-220", "doi": "10.1615/IntJMedMushrooms.2020033625", "pmid": "32479016", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01244", "slug": "liu-2020-triterpenoids-extracted-from-antrodia", "title": "Triterpenoids Extracted From Antrodia cinnamomea Mycelia Attenuate Acute Alcohol-Induced Liver Injury in C57BL/6 Mice via Suppression Inflammatory Response.", "authors": "Liu, Yange; Wang, Zhuqian; Kong, Fange; Teng, Lesheng; Zheng, Xiaoyi; Liu, Xingkai; Wang, Di", "year": 2020, "journal": "Frontiers in microbiology, 11, 1113", "doi": "10.3389/fmicb.2020.01113", "pmid": "32719658", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01245", "slug": "lo-2020-extracellular-polysaccharopeptides-from-fermented", "title": "Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus.", "authors": "Lo, Hui-Chen; Hsu, Tai-Hao; Lee, Chien-Hsing", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(5), 417-429", "doi": "10.1615/IntJMedMushrooms.2020034560", "pmid": "32749097", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01246", "slug": "RTHM-01246", "title": "The Novel Herbal Cocktail AGA Alleviates Oral Cancer through Inducing Apoptosis, Inhibited Migration and Promotion of Cell Cycle Arrest at SubG1 Phase.", "authors": "Lu, Jui-Hua; Chou, Yen-Ru; Deng, Yue-Hua; Huang, Mao-Suan; Chien, Shaw-Ting; Quynh, Bach Thi Nhu; Wu, Chia-Yu; Peláez Achtmann, Edlin Anahi; Cheng, Hsin-Chung; Dubey, Navneet Kumar; Deng, Win-Ping", "year": 2020, "journal": "Cancers, 12(11)", "doi": "10.3390/cancers12113214", "pmid": "33142749", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01247", "slug": "ma-2020-preparation-of-newly-identified", "title": "Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti-inflammation activities potential.", "authors": "Ma, Gaoxing; Kimatu, Benard Muinde; Yang, Wenjian; Pei, Fei; Zhao, Liyan; Du, Hengjun; Su, Anxiang; Hu, Qiuhui; Xiao, Hang", "year": 2020, "journal": "Journal of food science, 85(9), 2822-2831", "doi": "10.1111/1750-3841.15375", "pmid": "32794226", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01248", "slug": "machon-2020-expression-purification-and-applications", "title": "Expression, Purification, and Applications of the Recombinant Lectin PVL from Psathyrella velutina Specific for Terminal N-Acetyl-Glucosamine.", "authors": "Machon, Oriane; Varrot, Annabelle", "year": 2020, "journal": "Methods in molecular biology (Clifton, N.J.), 2132, 421-436", "doi": "10.1007/978-1-0716-0430-4_41", "pmid": "32306349", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01249", "slug": "RTHM-01249", "title": "A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding.", "authors": "Madsen, Martin Korsbak; Fisher, Patrick MacDonald; Stenbæk, Dea Siggaard; Kristiansen, Sara; Burmester, Daniel; Lehel, Szabolcs; Páleníček, Tomas; Kuchař, Martin; Svarer, Claus; Ozenne, Brice; Knudsen, Gitte M", "year": 2020, "journal": "European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 33, 71-80", "doi": "10.1016/j.euroneuro.2020.02.001", "pmid": "32146028", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01250", "slug": "mason-2020-me-myself-bye-regional", "title": "Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin.", "authors": "Mason, N L; Kuypers, K P C; Müller, F; Reckweg, J; Tse, D H Y; Toennes, S W; Hutten, N R P W; Jansen, J F A; Stiers, P; Feilding, A; Ramaekers, J G", "year": 2020, "journal": "Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(12), 2003-2011", "doi": "10.1038/s41386-020-0718-8", "pmid": "32446245", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01251", "slug": "RTHM-01251", "title": "Purified β-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis.", "authors": "Masterson, C H; Murphy, E J; Gonzalez, H; Major, I; McCarthy, S D; O'Toole, D; Laffey, J G; Rowan, N J", "year": 2020, "journal": "Letters in applied microbiology, 71(4), 405-412", "doi": "10.1111/lam.13358", "pmid": "32706908", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01252", "slug": "mertens-2020-therapeutic-mechanisms-of-psilocybin", "title": "Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression.", "authors": "Mertens, Lea J; Wall, Matthew B; Roseman, Leor; Demetriou, Lysia; Nutt, David J; Carhart-Harris, Robin L", "year": 2020, "journal": "Journal of psychopharmacology (Oxford, England), 34(2), 167-180", "doi": "10.1177/0269881119895520", "pmid": "31941394", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01253", "slug": "RTHM-01253", "title": "Evaluation of Polish wild Mushrooms as Beta-Glucan Sources.", "authors": "Mirończuk-Chodakowska, Iwona; Witkowska, Anna Maria", "year": 2020, "journal": "International journal of environmental research and public health, 17(19)", "doi": "10.3390/ijerph17197299", "pmid": "33036263", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01254", "slug": "monteyne-2020-mycoprotein-ingestion-stimulates-protein", "title": "Mycoprotein ingestion stimulates protein synthesis rates to a greater extent than milk protein in rested and exercised skeletal muscle of healthy young men: a randomized controlled trial.", "authors": "Monteyne, Alistair J; Coelho, Mariana O C; Porter, Craig; Abdelrahman, Doaa R; Jameson, Thomas S O; Jackman, Sarah R; Blackwell, Jamie R; Finnigan, Tim J A; Stephens, Francis B; Dirks, Marlou L; Wall, Benjamin T", "year": 2020, "journal": "The American journal of clinical nutrition, 112(2), 318-333", "doi": "10.1093/ajcn/nqaa092", "pmid": "32438401", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01255", "slug": "moorlag-2020-glucan-induces-protective-trained", "title": "β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.", "authors": "Moorlag, Simone J C F M; Khan, Nargis; Novakovic, Boris; Kaufmann, Eva; Jansen, Trees; van Crevel, Reinout; Divangahi, Maziar; Netea, Mihai G", "year": 2020, "journal": "Cell reports, 31(7), 107634", "doi": "10.1016/j.celrep.2020.107634", "pmid": "32433977", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01256", "slug": "morillon-2020-effect-of-lergothioneine-on", "title": "Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia.", "authors": "Morillon, Aude-Claire; Williamson, Rachel D; Baker, Philip N; Kell, Douglas B; Kenny, Louise C; English, Jane A; McCarthy, Fergus P; McCarthy, Cathal", "year": 2020, "journal": "PloS one, 15(3), e0230977", "doi": "10.1371/journal.pone.0230977", "pmid": "32231385", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01257", "slug": "RTHM-01257", "title": "β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies.", "authors": "Murphy, Emma J; Masterson, Claire; Rezoagli, Emanuele; O'Toole, Daniel; Major, Ian; Stack, Gary D; Lynch, Mark; Laffey, John G; Rowan, Neil J", "year": 2020, "journal": "The Science of the total environment, 732, 139330", "doi": "10.1016/j.scitotenv.2020.139330", "pmid": "32413619", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01258", "slug": "RTHM-01258", "title": "β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application.", "authors": "Murphy, Emma J; Rezoagli, Emanuele; Major, Ian; Rowan, Neil J; Laffey, John G", "year": 2020, "journal": "Journal of fungi (Basel, Switzerland), 6(4)", "doi": "10.3390/jof6040356", "pmid": "33322069", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01259", "slug": "RTHM-01259", "title": "Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties.", "authors": "Muszyńska, Bożena; Fijałkowska, Agata; Sułkowska-Ziaja, Katarzyna; Włodarczyk, Anna; Kaczmarczyk, Piotr; Nogaj, Ewa; Piętka, Jacek", "year": 2020, "journal": "Chemistry & biodiversity, 17(6), e2000213", "doi": "10.1002/cbdv.202000213", "pmid": "32271491", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01260", "slug": "RTHM-01260", "title": "Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties.", "authors": "Muszyńska, Bożena; Fijałkowska, Agata; Sułkowska-Ziaja, Katarzyna; Włodarczyk, Anna; Kaczmarczyk, Piotr; Nogaj, Ewa; Piętka, Jacek", "year": 2020, "journal": "Chemistry & biodiversity, 17(6), e2000213", "doi": "10.1002/cbdv.202000213", "pmid": "32271491", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01261", "slug": "RTHM-01261", "title": "Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties.", "authors": "Muszyńska, Bożena; Fijałkowska, Agata; Sułkowska-Ziaja, Katarzyna; Włodarczyk, Anna; Kaczmarczyk, Piotr; Nogaj, Ewa; Piętka, Jacek", "year": 2020, "journal": "Chemistry & biodiversity, 17(6), e2000213", "doi": "10.1002/cbdv.202000213", "pmid": "32271491", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01262", "slug": "RTHM-01262", "title": "Effect of mushroom polysaccharides from Pleurotus eryngii on obesity and gut microbiota in mice fed a high-fat diet.", "authors": "Nakahara, Daiki; Nan, Cui; Mori, Koichiro; Hanayama, Motoki; Kikuchi, Haruhisa; Hirai, Shizuka; Egashira, Yukari", "year": 2020, "journal": "European journal of nutrition, 59(7), 3231-3244", "doi": "10.1007/s00394-019-02162-7", "pmid": "31865422", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01263", "slug": "netea-2020-defining-trained-immunity-and", "title": "Defining trained immunity and its role in health and disease.", "authors": "Netea, Mihai G; Domínguez-Andrés, Jorge; Barreiro, Luis B; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A B; van der Meer, Jos W M; Mhlanga, Musa M; Mulder, Willem J M; Riksen, Niels P; Schlitzer, Andreas; Schultze, Joachim L; Stabell Benn, Christine; Sun, Joseph C; Xavier, Ramnik J; Latz, Eicke", "year": 2020, "journal": "Nature reviews. Immunology, 20(6), 375-388", "doi": "10.1038/s41577-020-0285-6", "pmid": "32132681", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01264", "slug": "neuwirthova-2020-immunostimulatory-and-anticancer-effect", "title": "Immunostimulatory and anticancer effect of Reishi and Coriol extracts at the level of clinical studies and their implementation in practice.", "authors": "Neuwirthová, Jana; Urbánková, Pavla; Smilek, Pavel", "year": 2020, "journal": "Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti, 33(6), 426-434", "doi": null, "pmid": "33685191", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01265", "slug": "RTHM-01265", "title": "Mushrooms Bioactive as Prebiotics to Modulate Gut Microbiota in Relationships with Causes and Prevention of Liver Diseases (Review).", "authors": "Nguepi, Tsopmejio Ivan Steve; Song, Hui", "year": 2020, "journal": "International journal of medicinal mushrooms, 22(6), 509-519", "doi": "10.1615/IntJMedMushrooms.2020034706", "pmid": "32865893", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01266", "slug": "RTHM-01266", "title": "Effect of Different Culture Media, Grain Sources and Alternate Substrates on the Mycelial Growth of Pleurotus eryngii and Pleurotus ostreatus.", "authors": "Nguyen, Thanh M; Ranamukhaarachchi, Senaratne L", "year": 2020, "journal": "Pakistan journal of biological sciences : PJBS, 23(3), 223-230", "doi": "10.3923/pjbs.2020.223.230", "pmid": "31944082", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01267", "slug": "RTHM-01267", "title": "Psilocybin: from ancient magic to modern medicine.", "authors": "Nichols, David E", "year": 2020, "journal": "The Journal of antibiotics, 73(10), 679-686", "doi": "10.1038/s41429-020-0311-8", "pmid": "32398764", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01268", "slug": "nie-2020-phytochemistry-and-pharmacological-activities", "title": "Phytochemistry and Pharmacological Activities of Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb.", "authors": "Nie, Anzheng; Chao, Yanhui; Zhang, Xiaochuan; Jia, Wenrui; Zhou, Zheng; Zhu, Chunsheng", "year": 2020, "journal": "Frontiers in pharmacology, 11, 505249", "doi": "10.3389/fphar.2020.505249", "pmid": "33071776", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01269", "slug": "RTHM-01269", "title": "Exploring the binding modes of cordycepin to human adenosine deaminase 1 (ADA1) compared to adenosine and 2'-deoxyadenosine.", "authors": "Niramitranon, Jitti; Pongprayoon, Prapasiri", "year": 2020, "journal": "Journal of molecular modeling, 26(2), 29", "doi": "10.1007/s00894-020-4289-8", "pmid": "31953681", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01270", "slug": "nowakowski-2020-the-two-faces-of", "title": "The two faces of Coprinus comatus-Functional properties and potential hazards.", "authors": "Nowakowski, Patryk; Naliwajko, Sylwia K; Markiewicz-Żukowska, Renata; Borawska, Maria H; Socha, Katarzyna", "year": 2020, "journal": "Phytotherapy research : PTR, 34(11), 2932-2944", "doi": "10.1002/ptr.6741", "pmid": "32462723", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01271", "slug": "ona-2020-potential-safety-benefits-and", "title": "Potential safety, benefits, and influence of the placebo effect in microdosing psychedelic drugs: A systematic review.", "authors": "Ona, Genís; Bouso, José Carlos", "year": 2020, "journal": "Neuroscience and biobehavioral reviews, 119, 194-203", "doi": "10.1016/j.neubiorev.2020.09.035", "pmid": "33031815", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01272", "slug": "pan-2020-regulatory-effect-of-grifola", "title": "Regulatory effect of Grifola frondosa extract rich in polysaccharides and organic acids on glycolipid metabolism and gut microbiota in rats.", "authors": "Pan, Yuyang; Wan, Xuzhi; Zeng, Feng; Zhong, Ruting; Guo, Weiling; Lv, Xu-Cong; Zhao, Chao; Liu, Bin", "year": 2020, "journal": "International journal of biological macromolecules, 155, 1030-1039", "doi": "10.1016/j.ijbiomac.2019.11.067", "pmid": "31712147", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01273", "slug": "pang-2020-pachymic-acid-protects-against", "title": "Pachymic acid protects against cerebral ischemia/reperfusion injury by the PI3K/Akt signaling pathway.", "authors": "Pang, Yingqiao; Zhu, Shaozhi; Pei, Haitao", "year": 2020, "journal": "Metabolic brain disease, 35(4), 673-680", "doi": "10.1007/s11011-020-00540-3", "pmid": "32140824", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01274", "slug": "pazzi-2020-ganoderma-lucidum-effects-on-mood", "title": "Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia.", "authors": "Pazzi, Francesco; Adsuar, Jose Carmelo; Dominguez-Munoz, Francisco Javier; Garcia-Gordillo, Miguel Angel; Gusi, Narcis; Collado-Mateo, Daniel", "year": 2020, "journal": "Healthcare (Basel, Switzerland), 8(4), 520", "doi": "10.3390/healthcare8040520", "pmid": "33265969", "tags": ["mood-depression", "reishi"], "studyType": "double-blind randomized placebo-controlled pilot trial", "evidenceStrength": "Null pilot evidence. Correct design, but underpowered and reporting no significant between-group differences, so it neither supports nor refutes a reishi mood effect.", "keyFinding": "Six grams per day of micro-milled Ganoderma lucidum carpophores for 6 weeks produced no statistically significant between-group differences versus placebo on happiness, depression, satisfaction with life, or health-related quality of life.\n\nA trend toward improved happiness and satisfaction with life and reduced depression was visible within the reishi group when comparing end of treatment to baseline, but within-group trends are not evidence of a treatment effect.\n\nThe authors describe the work as a pilot and state that protocol limitations mean further studies are needed.\n\nThis is the most directly relevant standalone human trial of reishi against a mood endpoint, and its primary comparison was null."}, {"rthcId": "RTHM-01275", "slug": "perduca-2020-structure-and-properties-of", "title": "Structure and properties of the oyster mushroom (Pleurotus ostreatus) lectin.", "authors": "Perduca, Massimiliano; 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Mozdianfard, Mohammad Reza; Shojaosadati, Seyed Abbas; Khorasani, Alireza Chackoshian; Saleh, Tayebeh", "year": 2020, "journal": "International journal of biological macromolecules, 144, 380-388", "doi": "10.1016/j.ijbiomac.2019.12.079", "pmid": "31837368", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01278", "slug": "RTHM-01278", "title": "Effects of Cultured Cordycep militaris on Sexual Performance and Erectile Function in Streptozotocin-Induced Diabetic Male Rats.", "authors": "Pohsa, Sureena; Hanchang, Wanthanee; Singpoonga, Nattapong; Chaiprasart, Peerasak; Taepavarapruk, Pornnarin", "year": 2020, "journal": "BioMed research international, 2020, 4198397", "doi": "10.1155/2020/4198397", "pmid": "33274209", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01279", "slug": "preller-2020-psilocybin-induces-timedependent-changes", "title": "Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity.", "authors": "Preller, Katrin H; 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Bell, Lynne; Shukitt-Hale, Barbara; Williams, Claire M", "year": 2024, "journal": "Neuroscience and biobehavioral reviews, 158, 105548", "doi": "10.1016/j.neubiorev.2024.105548", "pmid": "38246232", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01865", "slug": "cha-2024-the-relationship-between-mushroom", "title": "The Relationship between Mushroom Intake and Cognitive Performance: An Epidemiological Study in the European Investigation of Cancer-Norfolk Cohort (EPIC-Norfolk).", "authors": "Cha, Sara; Bell, Lynne; Williams, Claire M", "year": 2024, "journal": "Nutrients, 16(3)", "doi": "10.3390/nu16030353", "pmid": "38337638", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01866", "slug": "chen-2024-ergothioneine-improves-cognitive-function", "title": "Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model.", "authors": "Chen, Fangyang; Wang, Botao; Sun, Xin; Wang, Yage; Wang, Ruiyan; Li, Kaikai", "year": 2024, "journal": "Food & function, 15(23), 11686-11696", "doi": "10.1039/d4fo02321h", "pmid": "39530768", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01867", "slug": "chen-2024-phellinus-linteus-activates-treg", "title": "Phellinus linteus activates Treg cells via FAK to promote M2 macrophage polarization in hepatocellular carcinoma.", "authors": "Chen, Feihua; Gong, Mouchun; Weng, Dengcheng; Jin, Zhaoqing; Han, Guofeng; Yang, Ziqiang; Han, Junjun; Wang, Jianjiang", "year": 2024, "journal": "Cancer immunology, immunotherapy : CII, 73(1), 18", "doi": "10.1007/s00262-023-03592-3", "pmid": "38240856", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01868", "slug": "chen-2024-cordyceps-polysaccharides-a-review", "title": "Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects.", "authors": "Chen, Liping; Liu, Xiao; Zheng, Kaiyue; Wang, Yang; Li, Minglong; Zhang, Yuyu; Cui, Yuan; Deng, Sichun; Liu, Shiqi; Zhang, Gaoju; Li, Ling; He, Yuxin", "year": 2024, "journal": "Molecules (Basel, Switzerland), 29(21)", "doi": "10.3390/molecules29215107", "pmid": "39519748", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01869", "slug": "chen-2024-ganoderic-acid-t-a", "title": "Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels.", "authors": "Chen, Suyu; Chen, Kuangdee; Lin, Yihsiu; Wang, Ssuchia; Yu, Huichuan; Chang, Chaohsuan; Cheng, Tingchun; Hsieh, Chiaoyun; Li, Jiayi; Lai, Hsiaohsuan; Chen, Denghai; Huang, Chengpo", "year": 2024, "journal": "Toxicology and applied pharmacology, 491, 117069", "doi": "10.1016/j.taap.2024.117069", "pmid": "39142358", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01870", "slug": "RTHM-01870", "title": "Adjuvant activity of cordycepin, a natural derivative of adenosine from Cordyceps militaris, on an inactivated rabies vaccine in an animal model.", "authors": "Chen, Xin; Liao, Boyu; Ren, Tianci; Liao, Zhipeng; Huang, Zijie; Lin, Yujuan; Zhong, Shouhao; Li, Jiaying; Wen, Shun; Li, Yingyan; Lin, Xiaohan; Du, Xingchen; Yang, Yuhui; Guo, Jiubiao; Zhu, Xiaohui; Lin, Haishu; Liu, Rui; Wang, Jingbo", "year": 2024, "journal": "Heliyon, 10(2), e24612", "doi": "10.1016/j.heliyon.2024.e24612", "pmid": "38293396", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01871", "slug": "RTHM-01871", "title": "Insights into chemical components, health-promoting effects, and processing impact of golden chanterelle mushroom Cantharellus cibarius.", "authors": "Chen, Xinlei; Xu, Baojun", "year": 2024, "journal": "Food & function, 15(15), 7696-7732", "doi": "10.1039/d4fo00891j", "pmid": "38967456", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01872", "slug": "RTHM-01872", "title": "Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease.", "authors": "Chen, Xu-Jia; Deng, Zhou; Zhang, Le-Le; Pan, Yan; Fu, Jia; Zou, Liang; Bai, Zhaofang; Xiao, Xiaohe; Sheng, Feiya", "year": 2024, "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 172, 116222", "doi": "10.1016/j.biopha.2024.116222", "pmid": "38310653", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01873", "slug": "cherian-2024-magnesiumibogaine-therapy-in-veterans", "title": "Magnesium-ibogaine therapy in veterans with traumatic brain injuries.", "authors": "Cherian, Kirsten N; Keynan, Jackob N; Anker, Lauren; Faerman, Afik; Brown, Randi E; Shamma, Ahmed; Keynan, Or; Coetzee, John P; Batail, Jean-Marie; Phillips, Angela; Bassano, Nicholas J; Sahlem, Gregory L; Inzunza, Jose; Millar, Trevor; Dickinson, Jonathan; Rolle, C E; Keller, Jennifer; Adamson, Maheen; Kratter, Ian H; Williams, Nolan R", "year": 2024, "journal": "Nature medicine, 30(2), 373-381", "doi": "10.1038/s41591-023-02705-w", "pmid": "38182784", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01874", "slug": "choi-2024-mechanisms-of-psilocybin-on", "title": "Mechanisms of psilocybin on the treatment of posttraumatic stress disorder.", "authors": "Choi, Charles; Johnson, Danica E; Chen-Li, David; Rosenblat, Joshua", "year": 2024, "journal": "Journal of psychopharmacology (Oxford, England), 2698811241286771", "doi": "10.1177/02698811241286771", "pmid": "39360403", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01875", "slug": "chu-2024-the-nlrp3-inflammasome-a", "title": "The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD.", "authors": "Chu, Feng-Xin; Wang, Xiao; Li, Bo; Xu, Li-Li; Di, Bin", "year": 2024, "journal": "Inflammation research : official journal of the European Histamine Research Society ... [et al.], 73(2), 227-242", "doi": "10.1007/s00011-023-01831-y", "pmid": "38191853", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01876", "slug": "coelho-2024-the-impact-of-cannabidiol", "title": "The Impact of Cannabidiol Treatment on Anxiety Disorders: A Systematic Review of Randomized Controlled Clinical Trials.", "authors": "Coelho, Carly de Faria; Vieira, Rodolfo P; Araújo-Junior, Osvaldo Soares; Lopes-Martins, Pedro Sardinha Leonardo; Dos Santos, Larissa Gomes; Dias, Lucas Danilo; Filho, Alberto Souza de Sá; Leonardo, Patrícia Sardinha; Silva, Sandro Dutra E; Lopes-Martins, Rodrigo Alvaro Brandão", "year": 2024, "journal": "Life (Basel, Switzerland), 14(11)", "doi": "10.3390/life14111373", "pmid": "39598172", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01877", "slug": "RTHM-01877", "title": "Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity.", "authors": "Copa, Débora; Erritzoe, David; Giribaldi, Bruna; Nutt, David; Carhart-Harris, Robin; Tagliazucchi, Enzo", "year": 2024, "journal": "Journal of affective disorders, 353, 60-69", "doi": "10.1016/j.jad.2024.02.089", "pmid": "38423367", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01878", "slug": "del-2024-solute-transporter-octn1slc22a4-affects", "title": "Solute Transporter OCTN1/Slc22a4 Affects Disease Severity and Response to Infliximab in Experimental Colitis: Role of Gut Microbiota and Immune Modulation.", "authors": "Del Chierico, Federica; Masi, Letizia; Petito, Valentina; Baldelli, Valerio; Puca, Pierluigi; Benvenuto, Roberta; Fidaleo, Marco; Palucci, Ivana; Lopetuso, Loris Riccardo; Caristo, Maria Emiliana; Carrozza, Cinzia; Giustiniani, Maria Cristina; Nakamichi, Noritaka; Kato, Yukio; Putignani, Lorenza; Gasbarrini, Antonio; Pani, Giovambattista; Scaldaferri, Franco", "year": 2024, "journal": "Inflammatory bowel diseases, 30(12), 2259-2270", "doi": "10.1093/ibd/izae135", "pmid": "38944815", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01879", "slug": "dewi-2024-cordyceps-sinensis-accelerates-stem", "title": "Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise.", "authors": "Dewi, Luthfia; Liao, Yu-Chieh; Jean, Wei-Horng; Huang, Kuo-Chin; Huang, Chih-Yang; Chen, Liang-Kung; Nicholls, Andrew; Lai, Li-Fan; Kuo, Chia-Hua", "year": 2024, "journal": "Food & function, 15(8), 4010-4020", "doi": "10.1039/d3fo03770c", "pmid": "38501161", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01880", "slug": "RTHM-01880", "title": "NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity.", "authors": "Di Lorenzo, Ritamaria; Falanga, Danila; Ricci, Lucia; Colantuono, Antonio; Greco, Giovanni; Angelillo, Maura; Nugnes, Fiorella; Di Serio, Teresa; Costa, Dorothea; Tito, Annalisa; Laneri, Sonia", "year": 2024, "journal": "International journal of molecular sciences, 25(8)", "doi": "10.3390/ijms25084282", "pmid": "38673866", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01881", "slug": "RTHM-01881", "title": "Impact of Psilocybin on Peripheral Cytokine Production.", "authors": "DiRenzo, Dana; Barrett, Frederick S; Perin, Jamie; Darrah, Erika; Christopher-Stine, Lisa; Griffiths, Roland R", "year": 2024, "journal": "Psychedelic medicine (New Rochelle, N.Y.), 2(2), 109-115", "doi": "10.1089/psymed.2023.0039", "pmid": "40051582", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01882", "slug": "diskit-2024-optimization-of-mycelial-growth", "title": "Optimization of Mycelial Growth Parameters in Lion's Mane Edible Medicinal Mushroom Hericium erinaceus (Agaricomycetes) by Supplementation of Growth Hormones.", "authors": "Diskit, Stanzin; Gupta, Sachin; Gupta, Moni; Kour, Pavleen; Devi, Laxmi; Singh, Ranbir", "year": 2024, "journal": "International journal of medicinal mushrooms, 26(11), 41-49", "doi": "10.1615/IntJMedMushrooms.2024055204", "pmid": "39241162", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01883", "slug": "RTHM-01883", "title": "A Plea for Nuance: Should People with a Family History of Bipolar Disorder Be Excluded from Clinical Trials of Psilocybin Therapy?", "authors": "Downey, Amanda E; Bradley, Ellen R; Lerche, Anna S; O'Donovan, Aoife; Krystal, Andrew D; Woolley, Joshua", "year": 2024, "journal": "Psychedelic medicine (New Rochelle, N.Y.), 2(2), 61-73", "doi": "10.1089/psymed.2023.0051", "pmid": "40051581", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01884", "slug": "RTHM-01884", "title": "Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis.", "authors": "Du, Hengjun; Han, Yanhui; Ma, Gaoxing; Tan, Chen; Hu, Qiuhui; Xiao, Hang", "year": 2024, "journal": "Food research international (Ottawa, Ont.), 184, 114228", "doi": "10.1016/j.foodres.2024.114228", "pmid": "38609215", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01885", "slug": "el-2024-mixing-oak-and-eucalyptus", "title": "Mixing oak and eucalyptus sawdusts improves shiitake (Lentinula edodes) yield and nutritional value.", "authors": "El Sebaaly, Zeina; Nabhan, Stephanie; Outayek, Joelle; Nedelin, Teodor; N Sassine, Youssef", "year": 2024, "journal": "PloS one, 19(11), e0309787", "doi": "10.1371/journal.pone.0309787", "pmid": "39561164", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01886", "slug": "ern-2024-therapeutic-properties-of-inonotus", "title": "Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review.", "authors": "Ern, Phoebe Tee Yon; Quan, Tang Yin; Yee, Fung Shin; Yin, Adeline Chia Yoke", "year": 2024, "journal": "Mycology, 15(2), 144-161", "doi": "10.1080/21501203.2023.2260408", "pmid": "38813471", "tags": ["cancer-oncology", "metabolic-blood-sugar", "liver-kidney", "chemistry-compound-analysis"], "studyType": "review article", "evidenceStrength": "Full-text narrative review of Chaga compounds and extracts across mostly in vitro, animal, and mechanistic studies rather than human therapeutic trials.", "keyFinding": "This paper is a broad Chaga field map, not a human clinical review with pooled therapeutic outcomes.\n\nThe strongest structural move in the article is separating triterpenoids, polysaccharides, phenols or flavonoids, and crude extracts into different evidence buckets instead of flattening them into one Chaga effect.\n\nMost of the review's support comes from cell, rodent, and in silico studies, even when the conclusions lean toward treatment language.\n\nSeveral of the liveliest translational claims depend on preparation-specific details such as solvent, extraction method, host-tree contribution, or cultured-versus-wild source.\n\nThe authors end by acknowledging unresolved questions about food-matrix efficacy and compound or drug interactions, which is a narrower and more defensible conclusion than the headline therapeutic framing.\n\nThis 2024 review collects a large preclinical Chaga literature across triterpenoids, polysaccharides, phenols, and crude extracts. Its safest takeaway is that Chaga repeatedly hits inflammatory, metabolic, tumor-related, and organ-protective pathways in cells and animals, but the paper does not supply human trials or prove that wild conks, cultured material, and commercial products behave the same way."}, {"rthcId": "RTHM-01887", "slug": "erritzoe-2024-effect-of-psilocybin-versus", "title": "Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial.", "authors": "Erritzoe, David; Barba, Tommaso; Greenway, Kyle T; Murphy, Roberta; Martell, Jonny; Giribaldi, Bruna; Timmermann, Christopher; Murphy-Beiner, Ashleigh; Jones, Michelle Baker; Nutt, David; Weiss, Brandon; Carhart-Harris, Robin", "year": 2024, "journal": "EClinicalMedicine, 76, 102799", "doi": "10.1016/j.eclinm.2024.102799", "pmid": "39764567", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01888", "slug": "fang-2024-in-vitro-digestion-and", "title": "In vitro digestion and fecal fermentation of Tremella fuciformis exopolysaccharides from basidiospore-derived submerged fermentation.", "authors": "Fang, Yan; Zhang, Qi; Yu, Caiyuan; Xu, Xiaoqi; Lei, Peng; Xu, Hong; Li, Sha", "year": 2024, "journal": "Food research international (Ottawa, Ont.), 196, 115019", "doi": "10.1016/j.foodres.2024.115019", "pmid": "39614542", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01889", "slug": "fong-2024-ergothioneine-and-mitochondria-an", "title": "Ergothioneine and mitochondria: An important protective mechanism?", "authors": "Fong, Zachary Weijie; Tang, Richard Ming Yi; Cheah, Irwin Kee-Mun; Leow, Damien Meng Kiat; Chen, Lucrecia; Halliwell, Barry", "year": 2024, "journal": "Biochemical and biophysical research communications, 726, 150269", "doi": "10.1016/j.bbrc.2024.150269", "pmid": "38909533", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01890", "slug": "RTHM-01890", "title": "Erinacine S, a small active component derived from Hericium erinaceus, protects oligodendrocytes and alleviates mood abnormalities in cuprizone-exposed rodents.", "authors": "Fu, Jing-Ting; Yang, Chih-Jou; Lee, Li-Ya; Chen, Wan-Ping; Chen, Yu-Wen; Chen, Chin-Chu; Sun, Yuan-Ting; Yang, Chung-Shi; Tzeng, Shun-Fen", "year": 2024, "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 173, 116297", "doi": "10.1016/j.biopha.2024.116297", "pmid": "38394854", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01891", "slug": "gauld-2024-pollen-food-allergy-syndrome", "title": "Pollen food allergy syndrome secondary to molds and raw mushroom cross-reactivity: a case report.", "authors": "Gauld, Ryan; Walter, Graham; Zhu, Rongbo", "year": 2024, "journal": "Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 20(1), 2", "doi": "10.1186/s13223-023-00865-5", "pmid": "38178177", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01892", "slug": "gitsomboon-2024-tremella-fuciformis-beverage-improves", "title": "Tremella fuciformis beverage improves glycated hemoglobin A1c and waist circumference in overweight/obese prediabetic subjects: a randomized controlled trial.", "authors": "Gitsomboon, Sawika; Ratanapornsompong, Ganista; Ongphiphadhanakul, Boonsong; Thongpradit, Supranee; Chanprasertyothin, Suwannee; Chailurtkit, La-Or; Nimitphong, Hataikarn", "year": 2024, "journal": "BMC nutrition, 10(1), 44", "doi": "10.1186/s40795-024-00842-0", "pmid": "38439104", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01893", "slug": "RTHM-01893", "title": "Determination of psilocybin and psilocin content in multiple Psilocybe cubensis mushroom strains using liquid chromatography - tandem mass spectrometry.", "authors": "Goff, Roman; Smith, Morgan; Islam, Sabrina; Sisley, Sue; Ferguson, Jonathan; Kuzdzal, Scott; Badal, Sunil; Kumar, Arun Babu; Sreenivasan, Uma; Schug, Kevin A", "year": 2024, "journal": "Analytica chimica acta, 1288, 342161", "doi": "10.1016/j.aca.2023.342161", "pmid": "38220293", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01894", "slug": "RTHM-01894", "title": "Potential inhibitory effect of Auricularia auricula polysaccharide on advanced glycation end-products (AGEs).", "authors": "Gong, Pin; Pei, Shuya; Long, Hui; Yang, Wenjuan; Yao, Wenbo; Li, Nan; Wang, Jing; Zhao, Yanni; Chen, Fuxin; Xie, Jianwu; Guo, Yuxi", "year": 2024, "journal": "International journal of biological macromolecules, 262(Pt 1), 129856", "doi": "10.1016/j.ijbiomac.2024.129856", "pmid": "38423908", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01895", "slug": "grocholl-2024-listeria-monocytogenes-contamination-leads", "title": "Listeria monocytogenes Contamination Leads to Survival and Growth During Enoki Mushroom Cultivation.", "authors": "Grocholl, John; Ferguson, Martine; Hughes, Stephen; Trujillo, Socrates; Burall, Laurel S", "year": 2024, "journal": "Journal of food protection, 87(6), 100290", "doi": "10.1016/j.jfp.2024.100290", "pmid": "38701973", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01896", "slug": "gu-2024-screening-and-evaluation-of", "title": "Screening and evaluation of antioxidants for retinal pigment epithelial cell protection: L-ergothioneine as a novel therapeutic candidate through NRF2 activation.", "authors": "Gu, Sijie; Wu, Siqi; Lin, Zesong; Han, Zhuo; Mo, Kunlun; Huang, Huaxing; Li, Mingsen; Li, Gen; Ouyang, Hong; Wang, Li", "year": 2024, "journal": "Experimental eye research, 242, 109862", "doi": "10.1016/j.exer.2024.109862", "pmid": "38490292", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01897", "slug": "guo-2024-comparative-study-on-physicochemical", "title": "Comparative study on physicochemical properties and hypoglycemic activities of intracellular and extracellular polysaccharides from submerged fermentation of Morchella esculenta.", "authors": "Guo, Weihong; Yun, Jianmin; Wang, Biao; Xu, Siya; Ye, Chenguang; Wang, Xuerui; Qu, Yuling; Zhao, Fengyun; Yao, Liang", "year": 2024, "journal": "International journal of biological macromolecules, 278(Pt 2), 134759", "doi": "10.1016/j.ijbiomac.2024.134759", "pmid": "39151842", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01898", "slug": "halliwell-2024-are-agerelated-neurodegenerative-diseases", "title": "Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?", "authors": "Halliwell, Barry; Cheah, Irwin", "year": 2024, "journal": "Free radical biology & medicine, 217, 60-67", "doi": "10.1016/j.freeradbiomed.2024.03.009", "pmid": "38492784", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01899", "slug": "halman-2024-drugdrug-interactions-involving-classic", "title": "Drug-drug interactions involving classic psychedelics: A systematic review.", "authors": "Halman, Andreas; Kong, Geraldine; Sarris, Jerome; Perkins, Daniel", "year": 2024, "journal": "Journal of psychopharmacology (Oxford, England), 38(1), 3-18", "doi": "10.1177/02698811231211219", "pmid": "37982394", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01900", "slug": "han-2024-therapeutic-potential-of-cannabidiol", "title": "Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis.", "authors": "Han, Kevin; Wang, Jia-Yu; Wang, Peng-Yun; Peng, Yue-Chu-Han", "year": 2024, "journal": "Psychiatry research, 339, 116049", "doi": "10.1016/j.psychres.2024.116049", "pmid": "38924898", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01901", "slug": "hao-2024-effects-of-a-combination", "title": "Effects of a combination of Poria Cocos, Ziziphus spinose, and gamma-aminobutyric acid (GABA) on sleep quality and skin health: A randomized double-blind placebo-controlled clinical trial.", "authors": "Hao, Yining; Song, Weimin; Qu, Liping", "year": 2024, "journal": "Food science & nutrition, 12(6), 3883-3892", "doi": "10.1002/fsn3.4048", "pmid": "38873452", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01902", "slug": "hnydiuk-stefan-2024-impact-of-bottom-ash", "title": "Impact of bottom ash addition on Pleurotus ostreatus cultivation on coffee ground substrate.", "authors": "Hnydiuk-Stefan, Anna; Królczyk, Jolanta Beata; Matuszek, Dominika Barbara; Biłos, Łukasz; Grzywacz, Żaneta; Bożym, Marta; Junga, Robert; Bierczyński, Karol; Rai, Ritu", "year": 2024, "journal": "Scientific reports, 14(1), 31890", "doi": "10.1038/s41598-024-83434-z", "pmid": "39738424", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01903", "slug": "hu-2024-ameliorative-effect-of-an", "title": "Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model.", "authors": "Hu, Jutuan; Mei, Yuxia; Zhang, Heng; Li, Ji; Zhang, Min; Li, Yanbin; Yang, Wendi; Liu, Yangyang; Liang, Yunxiang", "year": 2024, "journal": "International journal of biological macromolecules, 265(Pt 1), 130959", "doi": "10.1016/j.ijbiomac.2024.130959", "pmid": "38499127", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01904", "slug": "hudspeth-2024-methyl-transfer-in-psilocybin", "title": "Methyl transfer in psilocybin biosynthesis.", "authors": "Hudspeth, Jesse; Rogge, Kai; Dörner, Sebastian; Müll, Maximilian; Hoffmeister, Dirk; Rupp, Bernhard; Werten, Sebastiaan", "year": 2024, "journal": "Nature communications, 15(1), 2709", "doi": "10.1038/s41467-024-46997-z", "pmid": "38548735", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01905", "slug": "iqbal-2024-exploring-therapeutic-potential-of", "title": "Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model.", "authors": "Iqbal, Touseef; Sohaib, Muhammad; Iqbal, Sanaullah; Rehman, Habib", "year": 2024, "journal": "Foods (Basel, Switzerland), 13(5)", "doi": "10.3390/foods13050709", "pmid": "38472823", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01906", "slug": "ishimoto-2024-trkb-phosphorylation-in-serum", "title": "TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans.", "authors": "Ishimoto, Takahiro; Yamashita, Reiya; Matsumoto, Ruri; Matsumoto, Satoshi; Matsuo, Yusuke; Nakao, Shunsuke; Masuo, Yusuke; Suzuki, Makoto; Kato, Yukio", "year": 2024, "journal": "NPJ science of food, 8(1), 11", "doi": "10.1038/s41538-024-00250-5", "pmid": "38321007", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01907", "slug": "RTHM-01907", "title": "Use of Ozone as a Substrate Treatment for the Control of Trichoderma in the Production of Pleurotus ostreatus.", "authors": "Jaramillo Mejía, Santiago; Colavolpe, María B; Ganuza, Mauricio; Albertó, Edgardo", "year": 2024, "journal": "Current microbiology, 81(7), 181", "doi": "10.1007/s00284-024-03691-z", "pmid": "38762690", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01908", "slug": "jeanblanc-2024-psilocybin-reduces-alcohol-selfadministration", "title": "Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats.", "authors": "Jeanblanc, Jérôme; Bordy, Romain; Fouquet, Grégory; Jeanblanc, Virginie; Naassila, Mickaël", "year": 2024, "journal": "Brain : a journal of neurology, 147(11), 3780-3788", "doi": "10.1093/brain/awae136", "pmid": "38703387", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01909", "slug": "jedrzejewski-2024-in-vitro-treatment-of", "title": "In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis.", "authors": "Jędrzejewski, Tomasz; Sobocińska, Justyna; Maciejewski, Bartosz; Spisz, Paulina; Walczak-Skierska, Justyna; Pomastowski, Paweł; Wrotek, Sylwia", "year": 2024, "journal": "Immunologic research, 73(1), 14", "doi": "10.1007/s12026-024-09574-6", "pmid": "39680299", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01910", "slug": "jia-2024-structural-elucidation-of-a", "title": "Structural Elucidation of a Polysaccharide from Flammulina velutipes and Its Lipid-Lowering and Immunomodulation Activities.", "authors": "Jia, Wei; Wang, Wenhan; Yu, Dongsheng; Yu, Yangchao; Feng, Zhan; Li, Hewen; Zhang, Jingsong; Zhang, Henan", "year": 2024, "journal": "Polymers, 16(5)", "doi": "10.3390/polym16050598", "pmid": "38475282", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01911", "slug": "RTHM-01911", "title": "Coffee with Cordyceps militaris and Hericium erinaceus Fruiting Bodies as a Source of Essential Bioactive Substances.", "authors": "Kała, Katarzyna; Cicha-Jeleń, Małgorzata; Hnatyk, Kamil; Krakowska, Agata; Sułkowska-Ziaja, Katarzyna; Szewczyk, Agnieszka; Lazur, Jan; Muszyńska, Bożena", "year": 2024, "journal": "Pharmaceuticals (Basel, Switzerland), 17(7)", "doi": "10.3390/ph17070955", "pmid": "39065803", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01912", "slug": "RTHM-01912", "title": "Auricularia auricula Anionic Polysaccharide Nanoparticles for Gastrointestinal Delivery of Pinus koraiensis Polyphenol Used in Bone Protection under Weightlessness.", "authors": "Kang, Li; Li, Qiao; Jing, Yonghui; Ren, Feiyan; Li, Erzhuo; Zeng, Xiangyin; Xu, Yier; Wang, Dongwei; Wang, Qiang; Sun, Guicai; Wei, Lijun; Diao, Yan", "year": 2024, "journal": "Molecules (Basel, Switzerland), 29(1)", "doi": "10.3390/molecules29010245", "pmid": "38202827", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01913", "slug": "RTHM-01913", "title": "Ergothioneine promotes longevity and healthy aging in male mice.", "authors": "Katsube, Makoto; Ishimoto, Takahiro; Fukushima, Yutaro; Kagami, Asuka; Shuto, Tsuyoshi; Kato, Yukio", "year": 2024, "journal": "GeroScience, 46(4), 3889-3909", "doi": "10.1007/s11357-024-01111-5", "pmid": "38446314", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01914", "slug": "kayes-2024-amanita-phalloidesassociated-liver-failure", "title": "Amanita phalloides-Associated Liver Failure: Molecular Mechanisms and Management.", "authors": "Kayes, Tahrima; Ho, Vincent", "year": 2024, "journal": "International journal of molecular sciences, 25(23)", "doi": "10.3390/ijms252313028", "pmid": "39684738", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01915", "slug": "kim-2024-effects-of-blue-light", "title": "Effects of Blue Light on Fruiting Body Production and Ergothioneine Content During Sawdust Cultivation of Shiitake (Lentinula edodes).", "authors": "Kim, Min-Jun; Jeong, Yeonsug; Park, Mi-Jeong; Jang, Yeongseon; Ka, Kang-Hyeon", "year": 2024, "journal": "Mycobiology, 52(6), 439-445", "doi": "10.1080/12298093.2024.2430052", "pmid": "39845181", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01916", "slug": "RTHM-01916", "title": "The Biphasic Activity of Auricularia Auricula-Judae Extract on Bone Homeostasis through Inhibition of Osteoclastogenesis and Modulation of Osteogenic Activity.", "authors": "Kim, Shin-Hye; Shin, Hye-Lim; Son, Tae Hyun; Kim, Dongsoo; Kim, Hwan-Gyu; Cho, Jae-Han; Choi, Sik-Won", "year": 2024, "journal": "Journal of microbiology and biotechnology, 34(12), 2576-2585", "doi": "10.4014/jmb.2408.08055", "pmid": "39467699", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01917", "slug": "RTHM-01917", "title": "Hepatoprotective Effect of Antrodia camphorata Mycelium Powder on Alcohol-Induced Liver Damage.", "authors": "Kim, Unyong; Jang, Sung-Il; Chen, Pei-Ni; Horii, Shingo; Wen, Wu-Che", "year": 2024, "journal": "Nutrients, 16(19)", "doi": "10.3390/nu16193406", "pmid": "39408373", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01918", "slug": "kim-2024-a-prospective-association-between", "title": "A prospective association between dietary mushroom intake and the risk of type 2 diabetes: the Korean Genome and Epidemiology Study-Cardiovascular Disease Association Study.", "authors": "Kim, Yu-Mi; Woo, Hye Won; Shin, Min-Ho; Koh, Sang Baek; Kim, Hyeon Chang; Kim, Mi Kyung", "year": 2024, "journal": "Epidemiology and health, 46, e2024017", "doi": "10.4178/epih.e2024017", "pmid": "38228086", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01919", "slug": "konozy-2024-from-inflammation-to-immune", "title": "From inflammation to immune regulation: The dual nature of dietary lectins in health and disease.", "authors": "Konozy, Emadeldin H E; Osman, Makarim Elfadil M", "year": 2024, "journal": "Heliyon, 10(20), e39471", "doi": "10.1016/j.heliyon.2024.e39471", "pmid": "39502251", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01920", "slug": "kou-2024-phellinus-linteus-polysaccharides-a", "title": "Phellinus linteus polysaccharides: A review on their preparation, structure-activity relationships, and drug delivery systems.", "authors": "Kou, Fang; Mei, Yuxia; Wang, Weihao; Wei, Xuetuan; Xiao, Hang; Wu, Xian", "year": 2024, "journal": "International journal of biological macromolecules, 258(Pt 1), 128702", "doi": "10.1016/j.ijbiomac.2023.128702", "pmid": "38072341", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01921", "slug": "kulshreshtha-2024-mushroom-as-prebiotics-a", "title": "Mushroom as Prebiotics: a Sustainable Approach for Healthcare.", "authors": "Kulshreshtha, Shweta", "year": 2024, "journal": "Probiotics and antimicrobial proteins, 16(3), 699-712", "doi": "10.1007/s12602-023-10164-5", "pmid": "37776487", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01922", "slug": "RTHM-01922", "title": "Deciphering psilocybin: Cytotoxicity, anti-inflammatory effects, and mechanistic insights.", "authors": "Laabi, Salma; LeMmon, Claire; Vogel, Callie; Chacon, Mariana; Jimenez, Victor M", "year": 2024, "journal": "International immunopharmacology, 130, 111753", "doi": "10.1016/j.intimp.2024.111753", "pmid": "38401463", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01923", "slug": "RTHM-01923", "title": "The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts.", "authors": "Lazić, Vesna; Klaus, Anita; Kozarski, Maja; Doroški, Ana; Tosti, Tomislav; Simić, Siniša; Vunduk, Jovana", "year": 2024, "journal": "Journal of fungi (Basel, Switzerland), 10(3)", "doi": "10.3390/jof10030225", "pmid": "38535233", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01924", "slug": "lee-2024-the-cerebral-protective-effect", "title": "The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways.", "authors": "Lee, Kam-Fai; Hsieh, Yung-Yu; Tung, Shui-Yi; Teng, Chih-Chuan; Cheng, Kung-Chuan; Hsieh, Meng-Chiao; Huang, Cheng-Yi; Lee, Ko-Chao; Lee, Li-Ya; Chen, Wan-Ping; Chen, Chin-Chu; Kuo, Hsing-Chun", "year": 2024, "journal": "Antioxidants (Basel, Switzerland), 13(3)", "doi": "10.3390/antiox13030371", "pmid": "38539904", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01925", "slug": "leow-2024-ergothioneinemediated-neuroprotection-of-human", "title": "Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons.", "authors": "Leow, Damien Meng-Kiat; Cheah, Irwin Kee-Mun; Chen, Lucrecia; Ng, Yang-Kai; Yeo, Crystal Jing-Jing; Halliwell, Barry; Ong, Wei-Yi", "year": 2024, "journal": "Antioxidants (Basel, Switzerland), 13(6)", "doi": "10.3390/antiox13060693", "pmid": "38929132", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01926", "slug": "li-2024-triterpenoids-from-ganoderma-lucidum", "title": "Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.", "authors": "Li, Dawei; Lin, Yuxin; Lv, Xia; Wu, Yuzhuo; Han, Chaoyan; Cao, Peng; Zhang, Guixin; Leng, Aijing; Zhou, Jian; Wang, Chao", "year": 2024, "journal": "Frontiers in pharmacology, 15, 1485209", "doi": "10.3389/fphar.2024.1485209", "pmid": "39619618", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01927", "slug": "RTHM-01927", "title": "The effects of different cooking methods on nutrients, bioactive components and antioxidant activities of Naematelia aurantialba were revealed by simulating in vitro digestion.", "authors": "Li, Guangzhi; Wang, Xin; Na, Zhiguo; Xiu, Weiye; Wang, Jingyang; Guan, Ying; Guo, Jinjin; Ma, Yongqiang", "year": 2024, "journal": "Food research international (Ottawa, Ont.), 198, 115342", "doi": "10.1016/j.foodres.2024.115342", "pmid": "39643343", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-01928", "slug": "li-2024-the-antifatigue-and-sleepaiding", "title": "The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.", "authors": "Li, Kexin; 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Moneypenny, A; Bozzo, G G; Perreault, M L", "year": 2025, "journal": "Frontiers in pharmacology, 16, 1582081", "doi": "10.3389/fphar.2025.1582081", "pmid": "40626304", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02185", "slug": "sprenger-2025-ergothioneine-controls-mitochondrial-function", "title": "Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.", "authors": "Sprenger, Hans-Georg; Mittenbühler, Melanie J; Sun, Yizhi; Van Vranken, Jonathan G; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A; Smythers, Amanda L; Vargas-Castillo, Ariana; Puszynska, Anna M; Spinelli, Jessica B; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L; Gygi, Steven P; Paulo, Joao A; Arthanari, Haribabu; Chouchani, Edward T; Sabatini, David M; Spiegelman, Bruce M", "year": 2025, "journal": "Cell metabolism, 37(4), 857-869.e9", "doi": "10.1016/j.cmet.2025.01.024", "pmid": "39965563", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02186", "slug": "sreedharan-2025-the-emerging-role-of", "title": "The Emerging Role of Oyster Mushrooms as a Functional Food for Complementary Cancer Therapy.", "authors": "Sreedharan, Priya Lakshmi; Kishorkumar, Malu; Neumann, Elke Gabriel; Kurup, Shyam S", "year": 2025, "journal": "Foods (Basel, Switzerland), 14(1)", "doi": "10.3390/foods14010128", "pmid": "39796417", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02187", "slug": "stroud-2025-perceived-changes-in-mental", "title": "Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey.", "authors": "Stroud, Jack; Rice, Charlotte; Orsini, Aaron; Schlosser, Marco; Lee, Justine; Mandy, Will; Kamboj, Sunjeev K", "year": 2025, "journal": "Psychopharmacology, 242(2), 373-387", "doi": "10.1007/s00213-024-06685-8", "pmid": "39367164", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02188", "slug": "sui-2025-ganoderic-acid-a-an", "title": "Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis.", "authors": "Sui, Qi; Zhu, Chengkai; Shi, Sha; Xu, Jiaqi; Zhang, Jingnan; Wang, Ao; Chen, Peng; Liang, Guang; Zhang, Yi", "year": 2025, "journal": "Journal of ethnopharmacology, 349, 119868", "doi": "10.1016/j.jep.2025.119868", "pmid": "40316150", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02189", "slug": "RTHM-02189", "title": "Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.", "authors": "Surendran, Geyan; Saye, Jake; Binti Mohd Jalil, Syahira; Spreadborough, Jack; Duong, Kyle; Shatwan, Israa M; Lilley, Dash; Heinrich, Michael; Dodd, Georgina F; Surendran, Shelini", "year": 2025, "journal": "Frontiers in nutrition, 12, 1405796", "doi": "10.3389/fnut.2025.1405796", "pmid": "40276537", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02190", "slug": "swieczkowski-2025-psilocybinassisted-psychotherapy-as-a", "title": "Psilocybin-assisted psychotherapy as a rapid-acting treatment for cancer-related depression and anxiety: Evidence from a network meta-analysis.", "authors": "Swieczkowski, Damian; Kwaśny, Aleksander; Pruc, Michal; Gaca, Zuzanna; Szarpak, Lukasz; Cubała, Wiesław J", "year": 2025, "journal": "International journal of psychiatry in medicine, 60(6), 603-623", "doi": "10.1177/00912174251337572", "pmid": "40279353", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02191", "slug": "swieczkowski-2025-efficacy-and-safety-of", "title": "Efficacy and safety of psilocybin in the treatment of Major Depressive Disorder (MDD): A dose-response network meta-analysis of randomized placebo-controlled clinical trials.", "authors": "Swieczkowski, Damian; Kwaśny, Aleksander; Pruc, Michal; Gaca, Zuzanna; Szarpak, Lukasz; Cubała, Wiesław J", "year": 2025, "journal": "Psychiatry research, 344, 116337", "doi": "10.1016/j.psychres.2024.116337", "pmid": "39754904", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02192", "slug": "syahputra-2025-ergothioneine-as-a-functional", "title": "Ergothioneine as a functional nutraceutical: Mechanisms, bioavailability, and therapeutic implications.", "authors": "Syahputra, Rony Abdi; Ahmed, Amer; Asriadi; Sitorus, Arnika Gloria Br; Putri, Sintia Karina; Tan, Michle William; Chandra, Qhelen Mayline; Brathennovic; Angiosaki, Yumiko; Lu, Felice Chrismary; Clister, Davini; Prananda, Arya Tjipta; Halim, Princella; Ribeiro, Rosy Iara Maciel de Azambuja; Nurkolis, Fahrul; Dalimunthe, Aminah", "year": 2025, "journal": "The Journal of nutritional biochemistry, 145, 110006", "doi": "10.1016/j.jnutbio.2025.110006", "pmid": "40541582", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02193", "slug": "takhor-2025-the-role-of-ergothioneine", "title": "The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review.", "authors": "Takhor, Nurfarah Hazwani; Phan, Chia Wei", "year": 2025, "journal": "Inflammopharmacology, 33(5), 2351-2375", "doi": "10.1007/s10787-025-01746-6", "pmid": "40249478", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02194", "slug": "timm-2025-substrate-effects-on-the", "title": "Substrate effects on the growth, yield, and nutritional composition of edible mushrooms.", "authors": "Timm, Thaynã Gonçalves; Arantes, Matheus Samponi Tucunduva; de Oliveira, Eduardo Henrique Silva; Tavares, Lorena Benathar Ballod; Mathias, Álvaro Luiz; da Silva, Vítor Renan; Helm, Cristiane Vieira", "year": 2025, "journal": "Advances in applied microbiology, 130, 159-190", "doi": "10.1016/bs.aambs.2024.11.005", "pmid": "40541368", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02195", "slug": "tng-2025-ergothioneine-treatment-ameliorates-the", "title": "Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models.", "authors": "Tng, Teddy J W; Leow, Damien M K; Goh, Geraldine; Wang, Ziyin; Liu, Yanmei; Tang, Richard M Y; Lai, Kate C L; Basil, Adeline H; Choong, Huey Ching; Goh, Wilson W B; Cheah, Irwin K; Ong, Wei-Yi; Halliwell, Barry; Lim, Kah-Leong", "year": 2025, "journal": "Journal of neurochemistry, 169(7), e70168", "doi": "10.1111/jnc.70168", "pmid": "40696819", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02196", "slug": "umbacia-2025-exploring-psilocybins-role-in", "title": "Exploring psilocybin's role in mental health and palliative medicine: a path to improved well-being.", "authors": "Umbacia, Maria-Alejandra; Leon, Marta Ximena; Quintero, Jose-Manuel; Castro, Lina-Maria; Paez, Veronica; Dodd, Seetal; Bustos, Rosa-Helena", "year": 2025, "journal": "Expert opinion on emerging drugs, 30(2), 99-108", "doi": "10.1080/14728214.2025.2488786", "pmid": "40178229", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02197", "slug": "van-2025-triacetin-and-a-mushroom", "title": "Triacetin and a Mushroom Blend Restore Butyrate Production by IBS Microbiomes Ex Vivo, Thus Promoting Barrier Integrity.", "authors": "Van den Abbeele, Pieter; Poppe, Jonas; Baudot, Aurélien; Vu, Lam Dai", "year": 2025, "journal": "International journal of molecular sciences, 26(19)", "doi": "10.3390/ijms26199388", "pmid": "41096656", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02198", "slug": "vanin-2025-characterization-of-the-polysaccharide", "title": "Characterization of the polysaccharide schizophyllan and schizophyllan-chitosan hydrogel formation by diffusing-wave spectroscopy.", "authors": "Vanin, Ana Paula; Camassola, Marli; Eiser, Erika; Stokke, Bjørn Torger", "year": 2025, "journal": "Carbohydrate polymers, 352, 123168", "doi": "10.1016/j.carbpol.2024.123168", "pmid": "39843073", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02199", "slug": "wall-2025-reduced-brain-responsiveness-to", "title": "Reduced Brain Responsiveness to Emotional Stimuli With Escitalopram But Not Psilocybin Therapy for Depression.", "authors": "Wall, Matthew B; Demetriou, Lysia; Giribaldi, Bruna; Roseman, Leor; Ertl, Natalie; Erritzoe, David; Nutt, David J; Carhart-Harris, Robin L", "year": 2025, "journal": "The American journal of psychiatry, 182(6), 569-582", "doi": "10.1176/appi.ajp.20230751", "pmid": "40329640", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02200", "slug": "wallace-2025-dshea-1994-celebrating-30", "title": "DSHEA 1994 - Celebrating 30 Years of Dietary Supplement Regulation in the United States.", "authors": "Wallace, Taylor C; Koturbash, Igor", "year": 2025, "journal": "Journal of dietary supplements, 22(1), 1-8", "doi": "10.1080/19390211.2024.2419434", "pmid": "39449550", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02201", "slug": "wan-2025-tremella-fuciformis-polysaccharides-alleviate", "title": "Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-κB Pathway.", "authors": "Wan, Yu-Hui; Cheng, Zeng-Jing; Fan, Ling-Xiang; Yang, De-Hong; Chen, Bing-Lin; Chen, Xiang-Xin; Zhu, Qing", "year": 2025, "journal": "Molecular neurobiology, 62(9), 11112-11129", "doi": "10.1007/s12035-025-04963-w", "pmid": "40263235", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02202", "slug": "wang-2025-hepatoprotective-effects-of-polysaccharide", "title": "Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.", "authors": "Wang, Dandan; Zhang, Menglian; Zhang, Yaowen; Yin, Zequn; Zhang, Shuang; Zhao, Zhiwei; Duan, Yajun", "year": 2025, "journal": "International journal of biological macromolecules, 301, 140444", "doi": "10.1016/j.ijbiomac.2025.140444", "pmid": "39884630", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02203", "slug": "wang-2025-ganoderma-lucidum-extract-reduces", "title": "Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers.", "authors": "Wang, Han; Tai, Meiling; Li, Wanzhao; Li, Yawen; Zhang, Zhimeng; Zhang, Dongli; Gan, Lishe; Li, Junhao; Song, Xiaojuan; Qiu, Honghong; Li, Manmei; Zhang, Heyun; Liu, Zhong", "year": 2025, "journal": "Fitoterapia, 184, 106627", "doi": "10.1016/j.fitote.2025.106627", "pmid": "40381851", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02204", "slug": "wang-2025-uncovering-hericenones-from-the", "title": "Uncovering Hericenones from the Fruiting Bodies of Hericium erinaceus through Interdisciplinary Collaboration.", "authors": "Wang, Junhong; Wu, Jing; Yamaguchi, Ryo; Nagai, Kaoru; Liu, Chengwei; Choi, Jae-Hoon; Hirai, Hirofumi; Xie, Xiaonan; Kobayashi, Shoji; Kawagishi, Hirokazu", "year": 2025, "journal": "Journal of natural products, 88(1), 80-85", "doi": "10.1021/acs.jnatprod.4c01018", "pmid": "39723452", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02205", "slug": "wang-2025-effects-of-a-cannabidiolterpene", "title": "Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study.", "authors": "Wang, Michael; Faust, Marcus; Abbott, Scott; Patel, Vikrant; Chang, Eric; Clark, John I; Stella, Nephi; Muchowski, Paul J", "year": 2025, "journal": "Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 21(1), 69-80", "doi": "10.5664/jcsm.11324", "pmid": "39167421", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02206", "slug": "wang-2025-flammulina-velutipes-polysaccharide-exerts", "title": "Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.", "authors": "Wang, Qiuyi; Wang, Senye; Cui, Lili; Zhang, Yu; Waterhouse, Geoffrey I N; Sun-Waterhouse, Dongxiao; Ma, Changyang; Kang, Wenyi", "year": 2025, "journal": "International journal of biological macromolecules, 309(Pt 3), 142985", "doi": "10.1016/j.ijbiomac.2025.142985", "pmid": "40210026", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02207", "slug": "wang-2025-psychedelics-and-prosocial-behaviors", "title": "Psychedelics and Pro-Social Behaviors: A Perspective on Autism Spectrum Disorders.", "authors": "Wang, Xue; Lin, Cong; Wang, Xiaohui", "year": 2025, "journal": "ACS pharmacology & translational science, 8(3), 903-906", "doi": "10.1021/acsptsci.5c00034", "pmid": "40109751", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02208", "slug": "wani-2025-healing-with-herbs-a", "title": "Healing with Herbs: A Systematic Review of Natural Treatments for Polycystic Ovary Syndrome.", "authors": "Wani, Rashmi; Shaikh, Mushtaque", "year": 2025, "journal": "JBRA assisted reproduction, 29(2), 359-366", "doi": "10.5935/1518-0557.20240110", "pmid": "40080781", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02209", "slug": "windsor-2025-comparative-study-of-chaga", "title": "Comparative Study of Chaga (Inonotus obliquus) Dietary Supplements Using Complementary Analytical Techniques.", "authors": "Windsor, Coleton; Kreynes, Anna E; Chilton, Jeff S; Chioffi, William A; Krishnamurthy, Arun; Ishii, Melissa", "year": 2025, "journal": "International journal of molecular sciences, 26(7)", "doi": "10.3390/ijms26072970", "pmid": "40243601", "tags": ["chemistry-compound-analysis"], "studyType": "comparative supplement-authentication study", "evidenceStrength": "analytical method / supplement quality evidence", "keyFinding": "Authentic chaga canker maintained a low-alpha, moderate-beta glucan pattern, while myceliated grain products flipped to high alpha-glucans that tracked cereal starch content.\n\nLugol staining and alpha-amylase digestion showed that the purple signal in myceliated grain products was starch-driven rather than a marker of authentic chaga chemistry.\n\nMelanin-rich dark canker materials separated cleanly from pale myceliated grain products on alkaline extraction and UV-Vis absorbance.\n\nAuthentic canker contained inotodiol, trametenolic acid, lanosterol, osmundacetone, and syringic acid, whereas the myceliated grain products did not reproduce that marker set.\n\nNMR and LC-QToF-MS showed that the canker extract stayed close to authentic chaga canker and that the myceliated grain products still looked chemically like their cereal substrates.\n\nThis is a strong product-authentication paper, not a health-effects paper. Across glucans, starch, melanin, triterpenoids, NMR, and LC-MS, authentic chaga canker and the one retail canker extract grouped together while the myceliated grain products mostly tracked their cereal substrates instead."}, {"rthcId": "RTHM-02210", "slug": "wolfgang-2025-research-and-implementation-of", "title": "Research and Implementation of Psychedelic-Assisted Therapy in the Veterans Health Administration.", "authors": "Wolfgang, Aaron S; McClair, Vetisha L; Schnurr, Paula P; Holtzheimer, Paul E; Woolley, Josh D; Stauffer, Christopher S; Wolf, R Cameron; States, Leith J; Benedek, David M; Capaldi, Vincent F; Bradley, John; Fuller, Matthew A; Smyth, Miriam J; Hermes, Eric D A; Tenhula, Wendy; Wiechers, Ilse R", "year": 2025, "journal": "The American journal of psychiatry, 182(1), 17-20", "doi": "10.1176/appi.ajp.20240751", "pmid": "39741441", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02211", "slug": "RTHM-02211", "title": "Cordycepin ameliorates diabetic nephropathy injury by activating the SLC7A11/GPX4 pathway.", "authors": "Wu, Bing; Wang, Jing; Yan, Xiaohui; Jin, Gang; Wang, Qiong", "year": 2025, "journal": "Journal of diabetes investigation, 16(6), 992-1000", "doi": "10.1111/jdi.14407", "pmid": "40120097", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02212", "slug": "xiong-2025-progress-in-the-study", "title": "Progress in the study of bioactivity, chemical composition and pharmacological mechanism of action in Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb.", "authors": "Xiong, Qi; Li, Zhuoran; Yang, Defeng; Liu, Xinze; Pu, Wanxu; Yue, Xitao; Jia, Kaikai; Wan, Xilin; Zou, Yuanjun", "year": 2025, "journal": "Frontiers in pharmacology, 16, 1521235", "doi": "10.3389/fphar.2025.1521235", "pmid": "40098611", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02213", "slug": "RTHM-02213", "title": "The Age-Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer.", "authors": "Xu, Yongzhao; Xu, Tianxiong; Huang, Chujun; Amakye, William Kwame; Li, Kaiqiang; Zhu, Ying; Ren, Jiaoyan", "year": 2025, "journal": "Molecular nutrition & food research, 69(5), e202400733", "doi": "10.1002/mnfr.202400733", "pmid": "39950425", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02214", "slug": "yamada-2025-beneficial-effects-of-enoki", "title": "Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study.", "authors": "Yamada, Shizuo; Shirai, Michiyo; Nagashima, Koji; Mochizuki, Jun; Ono, Ken; Kageyama, Shinji", "year": 2025, "journal": "Nutrients, 17(7)", "doi": "10.3390/nu17071208", "pmid": "40218966", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02215", "slug": "yang-2025-innovative-applications-of-medicinal", "title": "Innovative applications of medicinal mushrooms in functional foods and nutraceuticals: a focus on health-boosting beverages.", "authors": "Yang, Jing-Ya; Tao, Li; Lou, Dengji; Patabendige, Nimesha M; Ediriweera, Aseni N; Liu, Shujuan; Lu, Wenhua; Tarafder, Entaj; Rapior, Sylvie; Hapuarachchi, Kalani K", "year": 2025, "journal": "Frontiers in cellular and infection microbiology, 15, 1605301", "doi": "10.3389/fcimb.2025.1605301", "pmid": "40909340", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02216", "slug": "zeifman-2025-from-relaxed-beliefs-under", "title": "From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).", "authors": "Zeifman, Richard J; Spriggs, Meg J; Kettner, Hannes; Lyons, Taylor; Rosas, Fernando E; Mediano, Pedro A M; Erritzoe, David; Carhart-Harris, Robin L", "year": 2025, "journal": "Scientific reports, 15(1), 3651", "doi": "10.1038/s41598-023-28111-3", "pmid": "39881126", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02217", "slug": "RTHM-02217", "title": "Auricularia auriculaPolysaccharides Exert Anti-inflammatory Effects in Hepatic Fibrosis by the Gut-Liver Axis and Enhancing SCFA Metabolism.", "authors": "Zhang, Lu; Liu, Zhao-Xiu; Liu, Yi-Heng; Chen, Yuyan; Chen, Jing; Lu, Cui-Hua", "year": 2025, "journal": "Journal of agricultural and food chemistry, 73(8), 4617-4629", "doi": "10.1021/acs.jafc.4c07952", "pmid": "39945558", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02218", "slug": "zhang-2025-activity-analysis-and-inhibition", "title": "Activity Analysis and Inhibition Mechanism of Four Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Prepared from Flammulina velutipes by Enzymatic Hydrolysis.", "authors": "Zhang, Yajie; 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Nieves, Carmelo J; Hebert, Kaylan; Vivas, Camilo A; Rivero-Mendoza, Daniela; Colee, James; Tompkins, Thomas A; Dahl, Wendy J", "year": 2025, "journal": "Journal of dietary supplements, 22(5), 795-810", "doi": "10.1080/19390211.2025.2539876", "pmid": "40746014", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02279", "slug": "viazis-2025-an-overview-of-listeriosis", "title": "An Overview of Listeriosis Outbreak Investigations in the United States Linked to Imported Enoki Mushrooms and Associated Regulatory Activities, Research, and Food Safety Knowledge Gaps.", "authors": "Viazis, Stelios; Conrad, Amanda; Palacios, Alexandra; Busbee, Alexandra L; Kirchner, Margaret; Cataldo, Natalie; Wellman, Allison; Weed, Brett; Carstens, Christina K; Wagoner, Victoria; Burall, Laurel S; Salazar, Joelle K; Fay, Megan L; Nieves, Kenneth; Miller, Zachary; Ingram, David T; Hughes, Stephen; Baugher, Joseph; Hatch, Robert; Izyk, Scott; Pederson, Grace; Scott, Allison; Kristof, Matthew C; Williams, Laurie; Yeung, Lauren; Parker, Cary Chen; Bazaco, Michael C", "year": 2025, "journal": "Comprehensive reviews in food science and food safety, 24(5), e70292", "doi": "10.1111/1541-4337.70292", "pmid": "40958164", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02280", "slug": "hofmann-1958-psilocybin-isolation", "title": "Psilocybin, ein psychotroper Wirkstoff aus dem mexikanischen Rauschpilz Psilocybe mexicana Heim", "authors": "Hofmann, Albert; Heim, Roger; Brack, Arthur; Kobel, Hans", "year": 1958, "journal": "Experientia, 14(3), 107-109", "doi": "10.1007/BF02159243", "pmid": "13537892", "tags": [], "studyType": "Original chemistry report", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02281", "slug": "wang-2022-beta-glucan-combined-with-pd-1-pd-l1", "title": "β-Glucan Combined With PD-1/PD-L1 Checkpoint Blockade for Immunotherapy in Patients With Advanced Cancer.", "authors": "Wang, Meng; Bai, Yang; Pei, Jinjun; Li, Dongjie; Pu, Xiaolan; Zhu, Wenyu; Xia, Lei; Qi, Chunjian; Jiang, Hua; Ning, Yeshan", "year": 2022, "journal": "Frontiers in pharmacology, 2022, 13, 887457", "doi": "10.3389/fphar.2022.887457", "pmid": "35548349", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": "In a tumor mouse model, whole glucan particle (WGP) beta-glucan combined with PD-1/PD-L1-blocking antibodies increased immune cell recruitment, improved the balance between T-cell activation and immune tolerance, and delayed tumor progression compared with checkpoint blockade alone."}, {"rthcId": "RTHM-02282", "slug": "furqan-2024-imprime-pgg-and-pembrolizumab-nsclc", "title": "Phase Ib/II study of imprime PGG and pembrolizumab in patients with previously treated advanced non-small cell lung cancer (NSCLC): BTCRC LUN 15-017.", "authors": "Furqan, Muhammad; Malhotra, Jyoti; Shergill, Ardaman; Liu, Lei; Mott, Sarah L; Pasquinelli, Mary M; Hulbert, Alicia; Kennedy, Kelly; Feldman, Lawrence", "year": 2024, "journal": "Translational lung cancer research, 2024, 13, 11", "doi": "10.21037/tlcr-24-346", "pmid": "39670007", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": "In a single-arm phase Ib/II trial (n=33) of Imprime PGG (a 1,3/1,6 beta-glucan) plus pembrolizumab in previously treated advanced NSCLC, the combination was safe (MTD 4 mg/kg) but did not improve outcomes: confirmed objective response rate 10%, median PFS 2.6 months, median OS 11.1 months. Most patients had progressed on prior anti-PD-1/PD-L1 therapy."}, {"rthcId": "RTHM-02285", "slug": "paaventhan-2003-structure-of-fve-fip-family", "title": "A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family.", "authors": "Paaventhan, P; Joseph, J S; Seow, S V; Vaday, S; Robinson, H; Chua, K Y; Kolatkar, P R", "year": 2003, "journal": "Journal of molecular biology, 332(2), 461-70", "doi": "10.1016/s0022-2836(03)00923-9", "pmid": "12948495", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02287", "slug": "svoboda-2017-development-of-matrix-effectfree", "title": "Development of matrix effect-free MISPE-UHPLC-MS/MS method for determination of lovastatin in Pu-erh tea, oyster mushroom, and red yeast rice.", "authors": "Svoboda, Pavel; Sander, Daniel; Plachka, Katerina; Novakova, Lucie", "year": 2017, "journal": "Journal of pharmaceutical and biomedical analysis, 140, 367-376", "doi": "10.1016/j.jpba.2017.03.058", "pmid": "28410522", "tags": [], "studyType": "analytical method / food survey", "evidenceStrength": "", "keyFinding": "Using a matrix-effect-free molecularly imprinted solid-phase extraction UHPLC-MS/MS method, lovastatin was found in low or null amounts in three oyster mushroom samples purchased from Czech food stores."}, {"rthcId": "RTHM-02288", "slug": "piskov-2018-the-influence-of-the", "title": "The influence of the drying method for food properties and hypolipidemic potential of oyster mushrooms (Pleurotus ostreatus).", "authors": "Piskov, S I; Timchenko, L D; Rzhepakovsky, I V; Avanesyan, S S; Sizonenko, M N; Areshidze, D A; Kovalev, D A", "year": 2018, "journal": "Voprosy pitaniia, 87(2), 65-76", "doi": "10.24411/0042-8833-2018-10020", "pmid": "30592870", "tags": [], "studyType": "processing / analytical comparison", "evidenceStrength": "", "keyFinding": "Freeze-dried Pleurotus ostreatus retained 342 +/- 9.0 mg/kg lovastatin versus 190 +/- 6.0 mg/kg in dry-air-dried samples, a significant difference attributed to the gentler drying condition."}, {"rthcId": "RTHM-02289", "slug": "cohen-2014-chemical-composition-and-nutritional", "title": "Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms.", "authors": "Cohen, Nachshol; Cohen, Jacob; Asatiani, Mikheil D; Varshney, Vinay K; Yu, Hui-Tzu; Yang, Yi-Chi; Li, Yu-Hsuan; Mau, Jeng-Leun; Wasser, Solomon P", "year": 2014, "journal": "International journal of medicinal mushrooms, 16(3), 273-91", "doi": "10.1615/intjmedmushr.v16.i3.80", "pmid": "24941169", "tags": [], "studyType": "multi-species compositional survey", "evidenceStrength": "", "keyFinding": "Across 15 strains from 12 species, the highest lovastatin content in fruiting bodies was found in Hericium erinaceus (14.38 microg/g) and Ganoderma lucidum (11.54 microg/g) - neither an oyster mushroom."}, {"rthcId": "RTHM-02293", "slug": "zwaan-2026-the-effects-of-agaricus", "title": "The effects of Agaricus bisporus strain MES01706 on influenza vaccination responses: a double-blind, randomized, placebo-controlled intervention study in men and women aged 60 years or older.", "authors": "Zwaan, Willem; Mensink, Ronald P; Baars, Johan J P; van Peer, Arend F; van den Heuvel, Ellen G H M; Godschalk, Roger; Hageman, Geja; Popeijus, Herman E; Plat, Jogchum", "year": 2026, "journal": "Food & function", "doi": "10.1039/d6fo00915h", "pmid": "42475253", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02294", "slug": "roman-2013-shortterm-supplementation-with-active", "title": "Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine.", "authors": "Roman, Brooke E; Beli, Eleni; Duriancik, David M; Gardner, Elizabeth M", "year": 2013, "journal": "Nutrition research (New York, N.Y.), 33(1), 12-7", "doi": "10.1016/j.nutres.2012.11.001", "pmid": "23351405", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02295", "slug": "laue-2021-adjuvant-effect-of-orally", "title": "Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial.", "authors": "Laue, Christiane; Stevens, Yala; van Erp, Monique; Papazova, Ekaterina; Soeth, Edlyn; Pannenbeckers, Angelika; Stolte, Ellen; Böhm, Ruwen; Gall, Sophie Le; Falourd, Xavier; Ballance, Simon; Knutsen, Svein H; Pinheiro, Iris; Possemiers, Sam; Ryan, Paul M; Ross, R Paul; Stanton, Catherine; Wells, Jerry M; Werf, Sylvie van der; Mes, Jurriaan J; Schrezenmeir, Juergen", "year": 2021, "journal": "Nutrients, 13(8), 2683", "doi": "10.3390/nu13082683", "pmid": "34444843", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02297", "slug": "rodriguez-2021-effect-and-tolerability-of", "title": "Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study.", "authors": "Rodriguez, Julián Andrés Mateus; Bifano, Mónica; Roca Goma, Elvira; Plasencia, Carlos Méndez; Torralba, Anna Olivé; Font, Mercè Santó; Millán, Pedro Roy", "year": 2021, "journal": "Nutrients, 13(12), 4347", "doi": "10.3390/nu13124347", "pmid": "34959898", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02300", "slug": "chanput-2012-glucans-are-involved-in", "title": "β-Glucans are involved in immune-modulation of THP-1 macrophages.", "authors": "Chanput, Wasaporn; Reitsma, Marit; Kleinjans, Lennart; Mes, Jurriaan J; Savelkoul, Huub F J; Wichers, Harry J", "year": 2012, "journal": "Molecular nutrition & food research, 56(5), 822-33", "doi": "10.1002/mnfr.201100715", "pmid": "22648628", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02314", "slug": "bao-2006-immunomodulatory-effects-of-lingzhi", "title": "Immunomodulatory effects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis.", "authors": "Bao, Yi Xi; Wong, Chun Kwok; Li, Edmund Kwok Ming; Tam, Lai Shan; Leung, Ping Chung; Yin, Yi Bing; Lam, Christopher Wai Kei", "year": 2006, "journal": "Immunopharmacology and immunotoxicology, 28(2), 197-200", "doi": "10.1080/08923970600815097", "pmid": "16873089", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02315", "slug": "li-2007-safety-and-efficacy-of", "title": "Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial.", "authors": "Li, Edmund K; Tam, Lai-Shan; Wong, Chun Kwok; Li, Wai Ching; Lam, Christopher W K; Wachtel-Galor, Sissi; Benzie, Iris F F; Bao, Yi Xi; Leung, Ping Chung; Tomlinson, Brian", "year": 2007, "journal": "Arthritis and rheumatism, 57(7), 1143-50", "doi": "10.1002/art.22994", "pmid": "17907228", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02316", "slug": "masuda-2013-oral-administration-of-soluble", "title": "Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice.", "authors": "Masuda, Y; Inoue, H; Ohta, H; Miyake, A; Konishi, M; Nanba, H", "year": 2013, "journal": "International journal of cancer, 133(1), 108-19", "doi": "10.1002/ijc.27999", "pmid": "23280601", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02317", "slug": "masuda-2015-soluble-beta-glucan-from", "title": "Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity.", "authors": "Masuda, Y; Nawa, D; Nakayama, Y; Konishi, M; Nanba, H", "year": 2015, "journal": "Journal of leukocyte biology, 98(6), 1015-25", "doi": "10.1189/jlb.1A0814-415RR", "pmid": "26297795", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02318", "slug": "masuda-2008-inhibitory-effect-of-mdfraction", "title": "Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells.", "authors": "Masuda, Y; Murata, Y; Hayashi, M; Nanba, H", "year": 2008, "journal": "Biological & pharmaceutical bulletin, 31(6), 1104-8", "doi": null, "pmid": "18520039", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02319", "slug": "he-2019-the-biological-activities-of", "title": "The biological activities of the antitumor drug Grifola frondosa polysaccharide.", "authors": "He, Y; Zhang, L; Wang, H", "year": 2019, "journal": "Progress in molecular biology and translational science, 163(), 221-261", "doi": "10.1016/bs.pmbts.2019.02.010", "pmid": "31030750", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02321", "slug": "nakano-1996-intratumoral-administration-of-sizofiran", "title": "Intratumoral administration of sizofiran activates Langerhans cell and T-cell infiltration in cervical cancer.", "authors": "Nakano, T; Oka, K; Hanba, K; Morita, S", "year": 1996, "journal": "Clinical immunology and immunopathology, 79(1), 79-86", "doi": "10.1006/clin.1996.0053", "pmid": "8612354", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02324", "slug": "smigielski-2019-characterization-and-prediction-of", "title": "Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat.", "authors": "Smigielski, Lukasz; Kometer, Michael; Scheidegger, Milan; Krahenmann, Rainer; Huber, Theo; Vollenweider, Franz X", "year": 2019, "journal": "Scientific reports, 9(1), 14914", "doi": "10.1038/s41598-019-50612-3", "pmid": "31649304", "tags": ["psilocybin"], "studyType": "Randomized controlled trial", "evidenceStrength": "moderate", "keyFinding": "Compared with placebo, psilocybin administered during a 5-day mindfulness retreat enhanced post-intervention mindfulness and produced larger positive changes in psychosocial functioning at a 4-month follow-up, corroborated by external ratings."}, {"rthcId": "RTHM-02327", "slug": "kothe-1996-tetrapolar-fungal-mating-types", "title": "Tetrapolar fungal mating types: sexes by the thousands.", "authors": "Kothe, E", "year": 1996, "journal": "FEMS microbiology reviews, 18(1), 65-87", "doi": "", "pmid": "8672296", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02328", "slug": "ampere-2012-hypersensitivity-pneumonitis-induced-by", "title": "Hypersensitivity pneumonitis induced by Shiitake mushroom spores.", "authors": "Ampere, Alexandre; Delhaes, Laurence; Soots, Jacques; Bart, Frederic; Wallaert, Benoit", "year": 2012, "journal": "Medical mycology, 50(6), 654-7", "doi": "10.3109/13693786.2012.658091", "pmid": "22329454", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02329", "slug": "coelho-2017-fungal-sex-the-basidiomycota", "title": "Fungal Sex: The Basidiomycota.", "authors": "Coelho, Marco A; Bakkeren, Guus; Sun, Sheng; Hood, Michael E; Giraud, Tatiana", "year": 2017, "journal": "Microbiology spectrum, 5(3)", "doi": "10.1128/microbiolspec.funk-0046-2016", "pmid": "28597825", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02330", "slug": "auxier-2022-modeling-the-consequences-of", "title": "Modeling the consequences of the dikaryotic life cycle of mushroom-forming fungi on genomic conflict.", "authors": "Auxier, Benjamin; Cz&#xe1;r&#xe1;n, Tam&#xe1;s L; Aanen, Duur K", "year": 2022, "journal": "eLife, 11, e75917", "doi": "10.7554/eLife.75917", "pmid": "35441591", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02331", "slug": "kakizaki-2023-livecell-imaging-of-septins", "title": "Live-cell imaging of septins and cell polarity proteins in the growing dikaryotic vegetative hypha of the model mushroom Coprinopsis cinerea.", "authors": "Kakizaki, Tetsuya; Abe, Haruki; Kotouge, Yuuka; Matsubuchi, Mitsuki; Sugou, Mayu; Honma, Chiharu; Tsukuta, Kouki; Satoh, Souichi; Shioya, Tatsuhiro; Nakamura, Hiroe; Cannon, Kevin S; Woods, Benjamin L; Gladfelter, Amy; Takeshita, Norio; Muraguchi, Hajime", "year": 2023, "journal": "Scientific reports, 13(1), 10132", "doi": "10.1038/s41598-023-37115-y", "pmid": "37349479", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02332", "slug": "li-2024-insight-into-the-nuclear", "title": "Insight into the nuclear distribution patterns of conidia and the asexual life cycle of Polyporus umbellatus.", "authors": "Li, Shoujian; Li, Bing; Xu, Xinlei; Liu, Youyan; Xing, Yongmei; Guo, Shunxing", "year": 2024, "journal": "Fungal biology, 128(6), 2032-2041", "doi": "10.1016/j.funbio.2024.08.001", "pmid": "39174238", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02333", "slug": "fontanilla-2009-the-hallucinogen-nndimethyltryptamine-dmt", "title": "The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.", "authors": "Fontanilla, Dominique; Johannessen, Molly; Hajipour, Abdol R; Cozzi, Nicholas V; Jackson, Meyer B; Ruoho, Arnold E", "year": 2009, "journal": "Science (New York, N.Y.), 323(5916), 934-7", "doi": "10.1126/science.1166127", "pmid": "19213917", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02334", "slug": "dean-2019-biosynthesis-and-extracellular-concentrations", "title": "Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain.", "authors": "Dean, Jon G; Liu, Tiecheng; Huff, Sean; Sheler, Ben; Barker, Steven A; Strassman, Rick J; Wang, Michael M; Borjigin, Jimo", "year": 2019, "journal": "Scientific reports, 9(1), 9333", "doi": "10.1038/s41598-019-45812-w", "pmid": "31249368", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02335", "slug": "wiessner-2025-safety-tolerability-and-subjective", "title": "Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial.", "authors": "Wießner, Isabel; Falchi-Carvalho, Marcelo; Laborde, Sophie; Barros, Handersson; Bolcont, Raynara; Ruschi Silva, Sérgio; Pantrigo, Érica; Medina, Melanie; Arichelle, Flávia; Almeida, Raissa; Aires, Rosana; Nunes Ferreira, Luis Fernando; Dantas Corrêa, Luísa; Da Costa Bezerra, Romária Bárbara; Thie, Kaike; Silva-Costa, Natan; de Araújo Costa Neto, Luiz Antonio; Jales Lima de Queiroz, Marcos Vinícius; Galvão-Coelho, Nicole; Araujo, Draulio; Palhano-Fontes, Fernanda", "year": 2025, "journal": "European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 97, 16-27", "doi": "10.1016/j.euroneuro.2025.06.002", "pmid": "40532423", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02336", "slug": "van-2025-safety-pharmacokinetics-and-pharmacodynamics", "title": "Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial.", "authors": "van der Heijden, Katelijne V; Zuiker, Rob G J A; Otto, Marije E; Bryan, Christopher S; Stewart, Nancy; Stillwell, Christopher; De Kam, Marieke L; van Leuken, Marloes B; van Gerven, Joop M A; Jacobs, Gabriel E", "year": 2025, "journal": "Clinical and translational science, 18(5), e70234", "doi": "10.1111/cts.70234", "pmid": "40356576", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02337", "slug": "calder-2025-effects-of-psychoplastogens-on", "title": "Effects of psychoplastogens on blood levels of brain-derived neurotrophic factor (BDNF) in humans: a systematic review and meta-analysis.", "authors": "Calder, Abigail E; Hase, Adrian; Hasler, Gregor", "year": 2025, "journal": "Molecular psychiatry, 30(2), 763-776", "doi": "10.1038/s41380-024-02830-z", "pmid": "39613915", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02338", "slug": "bhat-2026-short-and-longacting-psychedelics", "title": "Short- and Long-Acting Psychedelics: Structure-Activity Relationships, Pharmacology, and Implications for Neuropsychiatric Therapeutics.", "authors": "Bhat, Anoushka; Zolali, Elmira; Sakib, Mahfuz A; Rahimian, Mohammad; McMahon, Lance R; German, Nadezhda; Obeng, Samuel", "year": 2026, "journal": "ACS chemical neuroscience, 17(12), 2278-2301", "doi": "10.1021/acschemneuro.6c00202", "pmid": "42257400", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02339", "slug": "gupta-2025-the-evolution-of-n", "title": "The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.", "authors": "Gupta, Swanti; Bhatnagar, Raj K; Gupta, Dinesh; K, Maharaj Kumari; Chopra, Amla", "year": 2025, "journal": "Psychopharmacology, 242(9), 1931-1953", "doi": "10.1007/s00213-025-06777-z", "pmid": "40210737", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02340", "slug": "vogt-2023-acute-effects-of-intravenous", "title": "Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants.", "authors": "Vogt, Severin B; Ley, Laura; Erne, Livio; 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Dai, Juan; Zhong, Yan; Wei, Xuelin; Wu, Mengxia; Zhang, Yuexin; Huang, Ai; Wang, Lijun; Huang, YuKun; Zhang, Chisong; Chen, Xianggui; Xiao, Hang", "year": 2021, "journal": "Food & function, 12(14), 6576-6587", "doi": "10.1039/d1fo00521a", "pmid": "34100044", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02357", "slug": "bu-2025-effect-of-flammulina-velutipes", "title": "Effect of Flammulina velutipes polysaccharidees on the quality and digestibility of fresh wet rice noodles: A study perspective from physicochemical and postprandial glucose homeostasis in vivo.", "authors": "Bu, Tingting; Kong, Xiao; Ren, Yuting; Zhang, Zhiguo; Hu, Weiwei; Natallia, Komarova; Cai, Ming; Sun, Peilong; Wu, Weicheng; Yang, Kai", "year": 2025, "journal": "Food chemistry, 484, 144335", "doi": "10.1016/j.foodchem.2025.144335", "pmid": "40273872", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02360", "slug": "gao-2003-effects-of-ganopoly-a", "title": "Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients.", "authors": "Gao, Yihuai; Zhou, Shufeng; Jiang, Wenqi; Huang, Min; Dai, Xihu", "year": 2003, "journal": "Immunological investigations, 32(3), 201-15", "doi": "10.1081/imm-120022979", "pmid": "12916709", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02361", "slug": "sun-2012-enhanced-mhc-class-i", "title": "Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides.", "authors": "Sun, Li-Xin; Lin, Zhi-Bin; Duan, Xin-Suo; Lu, Jie; Ge, Zhi-Hua; Li, Xue-Fei; Li, Xue-Jun; Li, Min; Xing, En-Hong; Song, You-Xin; Jia, Jing; Li, Wei-Dong", "year": 2012, "journal": "Journal of drug targeting, 20(7), 582-92", "doi": "10.3109/1061186X.2012.697167", "pmid": "22697491", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02365", "slug": "naranmandakh-2018-lanostane-triterpenoids-from", "title": "Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity.", "authors": "Naranmandakh, Shinen; Murata, Toshihiro; Odonbayar, Batsuren; Suganuma, Keisuke; Batkhuu, Javzan; Sasaki, Kenroh", "year": 2018, "journal": "Journal of natural medicines, 72(2), 523-529", "doi": "10.1007/s11418-018-1182-1", "pmid": "29417466", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02366", "slug": "shon-2003-inhibition-of-cytochrome-p450", "title": "Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus.", "authors": "Shon, Yun Hee; Nam, Kyung Soo", "year": 2003, "journal": "Biotechnology letters, 25(2), 167-172", "doi": "10.1023/a:1021935922722", "pmid": "12882294", "tags": [], "studyType": "in-vitro", "evidenceStrength": "preliminary", "keyFinding": "Phellinus linteus polysaccharides inhibited CYP1A1, CYP1A2, CYP2B1 and CYP2E1 activity in rat liver microsomes at 0.5-3 mg/ml. This is the only direct cytochrome P450 evidence for the mushroom, and it is an isolated-microsome result in a rat system, not a human drug-interaction study."}, {"rthcId": "RTHM-02367", "slug": "jin-2011-exacerbation-of-pemphigus-following", "title": "Exacerbation of pemphigus following Phellinus linteus ingestion.", "authors": "Jin, Seon Pil; Hong, Jong Soo; Chung, Jin Ho", "year": 2011, "journal": "Journal of the European Academy of Dermatology and Venereology, 25(4), 492-493", "doi": "10.1111/j.1468-3083.2010.03746.x", "pmid": "20561124", "tags": [], "studyType": "case-report", "evidenceStrength": "preliminary", "keyFinding": "A single published case report documents worsening of pemphigus, an autoantibody-driven blistering disease, in a patient after ingesting Phellinus linteus. It is the most serious adverse event linked to meshima anywhere in the literature."}, {"rthcId": "RTHM-02368", "slug": "li-2020-optimized-production-and-safety", "title": "Optimized production and safety evaluation of hispidin-enriched Sanghuangporus sanghuang mycelia.", "authors": "Li, I-Chen; Chen, Chin-Chu; Sheu, Shuenn-Jyi; Huang, I-Hsuan; Chen, Chien-Chih", "year": 2020, "journal": "Food science & nutrition, 8(4), 1864-1873", "doi": "10.1002/fsn3.1469", "pmid": "32328252", "tags": [], "studyType": "preclinical", "evidenceStrength": "moderate", "keyFinding": "A standard four-assay toxicology battery (Ames test, in vitro chromosome aberration, acute oral toxicity, bone marrow micronucleus) on hispidin-enriched Sanghuangporus sanghuang mycelia found no statistically significant difference from negative controls, indicating a very low order of toxicity."}, {"rthcId": "RTHM-02373", "slug": "thomann-2024-in-vitro-and-in", "title": "In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.", "authors": "Thomann, Jan; Kolaczynska, Karolina E; Stoeckmann, Oliver V; Rudin, Deborah; Vizeli, Patrick; Hoener, Marius C; Pryce, Christopher R; Vollenweider, Franz X; Liechti, Matthias E; Duthaler, Urs", "year": 2024, "journal": "Frontiers in Pharmacology, 15", "doi": "10.3389/fphar.2024.1391689", "pmid": "38741590", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02374", "slug": "koopmans-2021-metaanalysis-of-probability-estimates", "title": "Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19.", "authors": "Koopmans, Anne B; Braakman, Mario H; Vinkers, David J; Hoek, Hans W; van Harten, Peter N", "year": 2021, "journal": "Translational Psychiatry, 11(1)", "doi": "10.1038/s41398-020-01129-1", "pmid": "33627619", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02375", "slug": "zhao-2014-inotodiol-inhabits-proliferation-and", "title": "Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells.", "authors": "Zhao, Li-Wei; Zhong, Xiu-Hong; Yang, Shu-Yan; Zhang, Yu-Zhen; Yang, Nai-Jun", "year": 2014, "journal": "Asian Pacific journal of cancer prevention : APJCP, 15(7), 3195-9", "doi": "", "pmid": "24815470", "tags": [], "studyType": "cell-study", "evidenceStrength": "", "keyFinding": "Purified inotodiol inhibited HeLa cervical cancer cell proliferation dose-dependently and induced apoptosis, decreasing cyclin E and bcl-2 while increasing p27 and bax."}, {"rthcId": "RTHM-02376", "slug": "zhang-2018-inotodiol-suppresses-proliferation-of", "title": "Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of beta-catenin signaling.", "authors": "Zhang, Xin; Bao, Chun; Zhang, Jingping", "year": 2018, "journal": "Biomedicine & pharmacotherapy, 99, 142-150", "doi": "10.1016/j.biopha.2017.12.084", "pmid": "29331760", "tags": [], "studyType": "animal-study", "evidenceStrength": "", "keyFinding": "In rats with streptozotocin-induced diabetes and DMBA-induced breast tumors, inotodiol lowered blood glucose, reduced the proliferation marker PCNA, downregulated beta-catenin and its targets c-Myc and cyclin D1, and induced apoptosis."}, {"rthcId": "RTHM-02377", "slug": "elenkov-2005-cytokine-dysregulation-inflammation-and", "title": "Cytokine dysregulation, inflammation and well-being.", "authors": "Elenkov, Ilia J; Iezzoni, Domenic G; Daly, Adrian; Harris, Alan G; Chrousos, George P", "year": 2005, "journal": "Neuroimmunomodulation, 12(5), 255-269", "doi": "10.1159/000087104", "pmid": "16166805", "tags": [], "studyType": "Review", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02379", "slug": "lee-2026-kidney-injury-induced-by", "title": "Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model.", "authors": "Lee, Sua; Cui, Sheng; Fang, Xianying; Lee, Hanbi; Lim, Sun Woo; Shin, Yoo Jin; Li, Can; Yang, Chul Woo; Chung, Byung Ha", "year": 2026, "journal": "Journal of Korean medical science, 41(3), e37", "doi": "10.3346/jkms.2026.41.e37", "pmid": "41555803", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02380", "slug": "lumlertgul-2018-secondary-oxalate-nephropathy-a", "title": "Secondary Oxalate Nephropathy: A Systematic Review.", "authors": "Lumlertgul, Nuttha; Siribamrungwong, Monchai; Jaber, Bertrand L; Susantitaphong, Paweena", "year": 2018, "journal": "Kidney international reports, 3(6), 1363-1372", "doi": "10.1016/j.ekir.2018.07.020", "pmid": "30450463", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02381", "slug": "everard-2013-cross-talk-between-akkermansia", "title": "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.", "authors": "Everard, Amandine; Belzer, Clara; Geurts, Lucie; Ouwerkerk, Janneke P; Druart, Céline; Bindels, Laure B; Guiot, Yves; Derrien, Muriel; Muccioli, Giulio G; Delzenne, Nathalie M; de Vos, Willem M; Cani, Patrice D", "year": 2013, "journal": "Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9066-71", "doi": "10.1073/pnas.1219451110", "pmid": "23671105", "tags": [], "studyType": "Animal study", "evidenceStrength": "", "keyFinding": "Administering live Akkermansia muciniphila to high-fat-diet mice reversed fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance. Heat-killed bacteria produced no benefit, indicating the effect requires viable organisms."}, {"rthcId": "RTHM-02383", "slug": "taylor-2002-the-betaglucan-receptor-dectin1", "title": "The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages.", "authors": "Taylor, Philip R; Brown, Gordon D; Reid, Delyth M; Willment, Janet A; Martinez-Pomares, Luisa; Gordon, Siamon; Wong, Simon Y C", "year": 2002, "journal": "Journal of immunology (Baltimore, Md. : 1950), 169(7), 3876-3882", "doi": "10.4049/jimmunol.169.7.3876", "pmid": "12244185", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02384", "slug": "ross-2000-regulation-of-the-adhesion", "title": "Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein.", "authors": "Ross, Gordon D", "year": 2000, "journal": "Critical reviews in immunology, 20(3), 197-222", "doi": "", "pmid": "10968371", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02385", "slug": "xia-2002-function-of-the-lectin", "title": "Function of the lectin domain of Mac-1/complement receptor type 3 (CD11b/CD18) in regulating neutrophil adhesion.", "authors": "Xia, Yu; Borland, Gillian; Huang, Jun; Mizukami, Isaac F; Petty, Howard R; Todd, Robert F 3rd; Ross, Gordon D", "year": 2002, "journal": "Journal of immunology (Baltimore, Md. : 1950), 169(11), 6417-6426", "doi": "10.4049/jimmunol.169.11.6417", "pmid": "12444150", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02386", "slug": "allendorf-2005-c5amediated-leukotriene-b4amplified-neutrophil", "title": "C5a-mediated leukotriene B4-amplified neutrophil chemotaxis is essential in tumor immunotherapy facilitated by anti-tumor monoclonal antibody and beta-glucan.", "authors": "Allendorf, Daniel J; Yan, Jun; Ross, Gordon D; Hansen, Richard D; Baran, Jaroslav T; Subbarao, Kalavathi; Wang, Li; Haribabu, Bodduluri", "year": 2005, "journal": "Journal of immunology (Baltimore, Md. : 1950), 174(11), 7050-7056", "doi": "10.4049/jimmunol.174.11.7050", "pmid": "15905548", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02388", "slug": "rovensky-2011-the-effects-of-glucan", "title": "The effects of β-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis.", "authors": "Rovenský, Jozef; Stančíkova, Maria; Svík, Karol; Bauerová, Katarína; Jurčovičová, Jana", "year": 2011, "journal": "Rheumatology international, 31(4), 507-511", "doi": "10.1007/s00296-009-1258-z", "pmid": "20033413", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02389", "slug": "bauerova-2009-study-of-new-ways", "title": "Study of new ways of supplementary and combinatory therapy of rheumatoid arthritis with immunomodulators. Glucomannan and Imunoglukán in adjuvant arthritis.", "authors": "Bauerová, Katarína; Paulovičová, Ema; Mihalová, Danica; Svík, Karol; Ponist, Silvester", "year": 2009, "journal": "Toxicology and industrial health, 25(4-5), 329-335", "doi": "10.1177/0748233709102945", "pmid": "19651805", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02390", "slug": "choi-2025-simultaneous-gene-editing-of", "title": "Simultaneous gene editing of both nuclei in a dikaryotic strain of Ganoderma lucidum using Cas9-gRNA ribonucleoprotein.", "authors": "Choi, Yeon-Jae; Eom, Hyerang; Nandre, Rutuja; Kim, Minseek; Oh, Youn-Lee; Kim, Sinil; Ro, Hyeon-Su", "year": 2025, "journal": "Journal of microbiology (Seoul, Korea), 63(1), e.2409006", "doi": "10.71150/jm.2409006", "pmid": "39895071", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02391", "slug": "yamasaki-2022-gene-targeting-of-dikaryotic", "title": "Gene targeting of dikaryotic Pleurotus ostreatus nuclei using the CRISPR/Cas9 system.", "authors": "Yamasaki, Fuga; Nakazawa, Takehito; Oh, Minji; Bao, Dapeng; Kawauchi, Moriyuki; Sakamoto, Masahiro; Honda, Yoichi", "year": 2022, "journal": "FEMS microbiology letters, 369(1), fnac083", "doi": "10.1093/femsle/fnac083", "pmid": "36001999", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02392", "slug": "koshi-2024-transnuclei-crisprcas9-safe-approach", "title": "Trans-nuclei CRISPR/Cas9: safe approach for genome editing in the edible mushroom excluding foreign DNA sequences.", "authors": "Koshi, Daishiro; Sugano, Junko; Yamasaki, Fuga; Kawauchi, Moriyuki; Nakazawa, Takehito; Oh, Minji; Honda, Yoichi", "year": 2024, "journal": "Applied microbiology and biotechnology, 108(1), 548", "doi": "10.1007/s00253-024-13367-0", "pmid": "39738613", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02393", "slug": "waltz-2016-geneedited-crispr-mushroom-escapes", "title": "Gene-edited CRISPR mushroom escapes US regulation.", "authors": "Waltz, Emily", "year": 2016, "journal": "Nature, 532(7599), 293", "doi": "10.1038/nature.2016.19754", "pmid": "27111611", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02394", "slug": "sipka-1985-effect-of-lentinan-on", "title": "Effect of lentinan on the chemiluminescence produced by human neutrophils and the murine macrophage cell line C4M phi.", "authors": "Sipka, S; Abel, G; Csongor, J; Chihara, G; Fachet, J", "year": 1985, "journal": "International journal of immunopharmacology, 7(5), 747-751", "doi": "10.1016/0192-0561(85)90161-4", "pmid": "4044098", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02395", "slug": "xu-2022-lentinan-enhances-the-antitumor", "title": "Lentinan enhances the antitumor effects of Delta-like 1 via neutrophils.", "authors": "Xu, Hui; Qi, Zhen; Zhao, Qian; Xue, Jiao; Zhu, Jiahao; He, Yang; Liu, Gang; Qin, Songbing", "year": 2022, "journal": "BMC cancer, 22(1), 918", "doi": "10.1186/s12885-022-10011-w", "pmid": "36008793", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02396", "slug": "tanaka-2019-different-activities-of-antitumor", "title": "Different activities of antitumor immunomodulators to induce neutrophil adherence response.", "authors": "Tanaka, Mamoru; Abe, Shigeru", "year": 2019, "journal": "Drug discoveries & therapeutics, 13(6), 299-305", "doi": "10.5582/ddt.2019.01065", "pmid": "31956227", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02405", "slug": "ohm-2010-genome-sequence-of-the", "title": "Genome sequence of the model mushroom Schizophyllum commune.", "authors": "Ohm, Robin A; de Jong, Jan F; Lugones, Luis G; Aerts, Andrea; Kothe, Erika; Stajich, Jason E; de Vries, Ronald P; Record, Eric; Levasseur, Anthony; Baker, Scott E; Bartholomew, Kirk A; Coutinho, Pedro M; Erdmann, Susann; Fowler, Thomas J; Gathman, Allen C; Lombard, Vincent; Henrissat, Bernard; Knabe, Nicole; Kües, Ursula; Lilly, Walt W; Lindquist, Erika; Lucas, Susan; Magnuson, Jon K; Piumi, François; Raudaskoski, Marjatta; Salamov, Asaf; Schmutz, Jeremy; Schwarze, Francis W M R; vanKuyk, Patricia A; Horton, J Stephen; Grigoriev, Igor V; Wösten, Han A B", "year": 2010, "journal": "Nature biotechnology, 28(9), 957-63", "doi": "10.1038/nbt.1643", "pmid": "20622885", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02406", "slug": "zhu-2016-comparative-analysis-of-the", "title": "Comparative analysis of the secretomes of Schizophyllum commune and other wood-decay basidiomycetes during solid-state fermentation reveals its unique lignocellulose-degrading enzyme system.", "authors": "Zhu, Ning; Liu, Jiawen; Yang, Jinshui; Lin, Yujian; Yang, Yi; Ji, Lei; Li, Meng; Yuan, Hongli", "year": 2016, "journal": "Biotechnology for biofuels, 9, 42", "doi": "10.1186/s13068-016-0461-x", "pmid": "26900401", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02407", "slug": "riley-2014-extensive-sampling-of-basidiomycete", "title": "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the white-rot/brown-rot paradigm for wood decay fungi.", "authors": "Riley, Robert; Salamov, Asaf A; Brown, Daren W; Nagy, Laszlo G; Floudas, Dimitrios; Held, Benjamin W; Levasseur, Anthony; Lombard, Vincent; Morin, Emmanuelle; Otillar, Robert; Lindquist, Erika A; Sun, Hui; LaButti, Kurt M; Schmutz, Jeremy; Jabbour, Dina; Luo, Hong; Baker, Scott E; Pisabarro, Antonio G; Walton, Jonathan D; Blanchette, Robert A; Henrissat, Bernard; Martin, Francis; Cullen, Dan; Hibbett, David S; Grigoriev, Igor V", "year": 2014, "journal": "Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9923-8", "doi": "10.1073/pnas.1400592111", "pmid": "24958869", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02408", "slug": "tovar-herrera-2018-schizophyllum-commune-an-unexploited", "title": "Schizophyllum commune: An unexploited source for lignocellulose degrading enzymes.", "authors": "Tovar-Herrera, Omar Eduardo; Martha-Paz, Adriana Mayrel; Pérez-LLano, Yordanis; Aranda, Elisabet; Tacoronte-Morales, Juan Enrique; Pedroso-Cabrera, María Teresa; Arévalo-Niño, Katiushka; Folch-Mallol, Jorge Luis; Batista-García, Ramón Alberto", "year": 2018, "journal": "MicrobiologyOpen, 7(3), e00637", "doi": "10.1002/mbo3.637", "pmid": "29785766", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02409", "slug": "james-1999-evidence-for-limited-intercontinental", "title": "EVIDENCE FOR LIMITED INTERCONTINENTAL GENE FLOW IN THE COSMOPOLITAN MUSHROOM, SCHIZOPHYLLUM COMMUNE.", "authors": "James, Timothy Y; Porter, David; Hamrick, James L; Vilgalys, Rytas", "year": 1999, "journal": "Evolution; international journal of organic evolution, 53(6), 1665-1677", "doi": "10.1111/j.1558-5646.1999.tb04552.x", "pmid": "28565469", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02410", "slug": "chu-2025-evidence-for-the-existence", "title": "Evidence for the Existence of Mating Subtypes Within the Schizophyllum commune: Mating Behavior and Genetic Divergence.", "authors": "Chu, Chen; Li, Dongxu; Gu, Linqing; Yang, Sihai; Liu, Changhong", "year": 2025, "journal": "Journal of fungi (Basel, Switzerland), 11(4), 277", "doi": "10.3390/jof11040277", "pmid": "40278098", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02411", "slug": "chowdhary-2013-schizophyllum-commune-as-an", "title": "Schizophyllum commune as an emerging fungal pathogen: a review and report of two cases.", "authors": "Chowdhary, A; Randhawa, H S; Gaur, S N; Agarwal, K; Kathuria, S; Roy, P; Klaassen, C H; Meis, J F", "year": 2013, "journal": "Mycoses, 56(1), 1-10", "doi": "10.1111/j.1439-0507.2012.02190.x", "pmid": "22524529", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02412", "slug": "cavanna-2019-human-infections-due-to", "title": "Human infections due to Schizophyllumcommune: Case report and review of the literature.", "authors": "Cavanna, C; Pagella, F; Esposto, M C; Tamarozzi, F; Clemente, L; Marone, P; Matti, E; Lallitto, F", "year": 2019, "journal": "Journal de mycologie medicale, 29(4), 365-371", "doi": "10.1016/j.mycmed.2019.100897", "pmid": "31543381", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02413", "slug": "wu-2026-schizophyllum-communeassociated-allergic-bronchopulmonary", "title": "Schizophyllum commune-associated allergic bronchopulmonary mycosis in a postoperative lung cancer patient: A case report and comprehensive literature review.", "authors": "Wu, Ningpei; Liang, Yi; Yan, Qunfeng", "year": 2026, "journal": "Medicine, 105(7), e47480", "doi": "10.1097/MD.0000000000047480", "pmid": "41686546", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02419", "slug": "el-2022-nutritional-profile-and-health", "title": "Nutritional Profile and Health Benefits of Ganoderma lucidum \"Lingzhi, Reishi, or Mannentake\" as Functional Foods: Current Scenario and Future Perspectives.", "authors": "El Sheikha, Aly Farag", "year": 2022, "journal": "Foods (Basel, Switzerland), 11(7), 1030", "doi": "10.3390/foods11071030", "pmid": "35407117", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02420", "slug": "awashra-2026-b-vitamins-and-cardiovascular", "title": "B vitamins and cardiovascular health: mechanisms, clinical evidence, and precision prevention strategies.", "authors": "Awashra, Ameer; AbuBaha, Mohammed; Istetieh, Kareem; Sandouka, Dana; Aldwaik, Samia; AbuBaha, Bara; Saife, Sarah; Emara, Ahmed; Zahran, Anwar; Elgendy, Mohamed S; Shubietah, Abdalhakim; Baniowda, Muath A", "year": 2026, "journal": "Nutrition & metabolism, 23(1)", "doi": "10.1186/s12986-026-01125-0", "pmid": "42067935", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02421", "slug": "al-2026-onecarbon-metabolism-and-cardiovascular", "title": "One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.", "authors": "Al Qassab, Mohamad; Bou Ghanem, Ayman; Hussayni, Yaman; Kadbey, Raghid; Ratel, Yara; Yehya, Shereen; Zahr, Maysaa; Ghadieh, Hilda E; Abi Khattar, Ziad; Azar, Sami; Kanaan, Amjad; Harb, Frederic", "year": 2026, "journal": "Biochemistry and biophysics reports, 46, 102544", "doi": "10.1016/j.bbrep.2026.102544", "pmid": "41890215", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02429", "slug": "zhang-2026-ganoderma-lucidum-mediates-microglial", "title": "Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway.", "authors": "Zhang, L; Chen, J; Yuen, S; Wu, M; Li, W; Yan, S; Shen, J", "year": 2026, "journal": "Chinese medicine, 21", "doi": "10.1186/s13020-026-01327-x", "pmid": "41957858", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02431", "slug": "fang-2025-combined-transcriptomic-and-metabolomic", "title": "Combined Transcriptomic and Metabolomic Analyses of the Response of Ganoderma lucidum to Elevated CO2.", "authors": "Fang, Tingting; Chen, Lu; Yao, Hui; Li, Ye; Liu, Guohui; Wu, Shaofeng; Lan, Jin; Chen, Xiangdong", "year": 2025, "journal": "Journal of fungi (Basel, Switzerland), 12(1), 5", "doi": "10.3390/jof12010005", "pmid": "41590417", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02439", "slug": "yue-2008-effects-of-cordyceps-sinensis", "title": "Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells.", "authors": "Yue, Grace Gar-Lee; Lau, Clara Bik-San; Fung, Kwok-Pui; Leung, Ping-Chung; Ko, Wing-Hung", "year": 2008, "journal": "Journal of ethnopharmacology, 117(1), 92-101", "doi": "10.1016/j.jep.2008.01.030", "pmid": "18358654", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02444", "slug": "chen-2020-antiinflammatory-effects-of-a", "title": "Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma.", "authors": "Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Leong, Pou Kuan; Yan, Choly Tat Ming; Ko, Kam Ming", "year": 2020, "journal": "Molecules, 25(18), 4051", "doi": "10.3390/molecules25184051", "pmid": "32899766", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02445", "slug": "song-2023-cordyceps-militaris-polysaccharide-alleviates", "title": "Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota.", "authors": "Song, Lanyue; Yang, Jintao; Kong, Weihan; Liu, Yang; Liu, Shuyan; Su, Ling", "year": 2023, "journal": "International journal of biological macromolecules, 238, 124333", "doi": "10.1016/j.ijbiomac.2023.124333", "pmid": "37030458", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02446", "slug": "kometer-2013-activation-of-serotonin-2a", "title": "Activation of serotonin 2A receptors underlies the psilocybin-induced effects on α oscillations, N170 visual-evoked potentials, and visual hallucinations.", "authors": "Kometer, Michael; Schmidt, André; Jäncke, Lutz; Vollenweider, Franz X", "year": 2013, "journal": "The Journal of neuroscience, 33(25), 10544-10551", "doi": "10.1523/JNEUROSCI.3007-12.2013", "pmid": "23785166", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02447", "slug": "hesselgrave-2021-harnessing-psilocybin-antidepressantlike-behavioral", "title": "Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice.", "authors": "Hesselgrave, Natalie; Troppoli, Timothy A; Wulff, Andreas B; Cole, Anthony B; Thompson, Scott M", "year": 2021, "journal": "Proceedings of the National Academy of Sciences, 118(17)", "doi": "10.1073/pnas.2022489118", "pmid": "33850049", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02452", "slug": "harrison-2025-wolves-among-sheep-sexual", "title": "Wolves Among Sheep: Sexual Violations in Psychedelic-Assisted Therapy.", "authors": "Harrison, Tahlia R; Faber, Sonya C; Zare, Manzar; Fontaine, Matthieu; Williams, Monnica T", "year": 2025, "journal": "The American journal of bioethics : AJOB, 25(1), 40-55", "doi": "10.1080/15265161.2024.2433423", "pmid": "39804304", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02453", "slug": "holoyda-2023-the-perilous-policy-of", "title": "The Perilous Policy of Oregon's Psilocybin Services.", "authors": "Holoyda, Brian", "year": 2023, "journal": "The journal of the American Academy of Psychiatry and the Law, 51(2), 160-166", "doi": "10.29158/JAAPL.230023-23", "pmid": "37311597", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02454", "slug": "holoyda-2023-malpractice-and-other-civil", "title": "Malpractice and Other Civil Liability in Psychedelic Psychiatry.", "authors": "Holoyda, Brian James", "year": 2023, "journal": "Psychiatric services (Washington, D.C.), 74(1), 92-95", "doi": "10.1176/appi.ps.20220528", "pmid": "36587277", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02455", "slug": "mcnamee-2023-studying-harms-is-key", "title": "Studying Harms Is Key to Improving Psychedelic-Assisted Therapy-Participants Call for Changes to Research Landscape.", "authors": "McNamee, Sarah; Devenot, Nese; Buisson, Meaghan", "year": 2023, "journal": "JAMA psychiatry, 80(5), 411-412", "doi": "10.1001/jamapsychiatry.2023.0099", "pmid": "36988924", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02456", "slug": "chwyl-2026-prevalence-and-predictors-of", "title": "Prevalence and predictors of sexual and physical violence during psychedelic use in a US population-based study.", "authors": "Chwyl, Christina; Ladka, Michael S; Black, Joshua C; Rockhill, Karilynn M; Dart, Richard C; Luoma, Jason B; Monte, Andrew A", "year": 2026, "journal": "World psychiatry : official journal of the World Psychiatric Association (WPA), 25(2), 333-334", "doi": "10.1002/wps.70071", "pmid": "42136434", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02458", "slug": "sweeney-2026-advances-in-enzymatic-measurement", "title": "Advances in Enzymatic Measurement of β-Glucan in Mushrooms, Yeast, Algae, and Dietary Supplements.", "authors": "Sweeney, Lucie C; Walsh, Caoilfhionn; O'Cochlain, Amaya; Ivory, Ruth; Mangan, David", "year": 2026, "journal": "Journal of AOAC International", "doi": "10.1093/jaoacint/qsag041", "pmid": "42152188", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": "The standard indirect beta-glucan method (total glucan minus alpha-glucan) shows matrix-dependent limitations in supplement formulations containing resistant starches, trehalose, and sugar alcohols."}, {"rthcId": "RTHM-02459", "slug": "keerthana-2026-unveiling-the-glucan-profile", "title": "Unveiling the glucan profile: a comparative study of Lion's Mane and Shiitake mushrooms.", "authors": "Keerthana, C S; Kumari, Rozy; Beura, Muskan; Sharan, Sumit; Sharma, Susheel Kumar; Ganjoo, Ananta; Dahuja, Anil; Krishnan, Veda", "year": 2026, "journal": "Natural product research, 40", "doi": "10.1080/14786419.2025.2509142", "pmid": "40407020", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": "Shiitake fruiting bodies measured 13.4-26.2% beta-glucan against only 0.8-5.5% alpha-glucan; Lion's Mane measured 17.4% beta-glucan against 0.673% alpha-glucan."}, {"rthcId": "RTHM-02463", "slug": "collins-2024-psychedelics-for-the-treatment", "title": "Psychedelics for the Treatment of Obsessive-Compulsive Disorder: Efficacy and Proposed Mechanisms.", "authors": "Collins, Helen M", "year": 2024, "journal": "The international journal of neuropsychopharmacology, 27(12), pyae057", "doi": "10.1093/ijnp/pyae057", "pmid": "39611453", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02464", "slug": "gray-2001-paradoxical-trafficking-and-regulation", "title": "Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists.", "authors": "Gray, J A; Roth, B L", "year": 2001, "journal": "Brain research bulletin, 56(5), 441-51", "doi": "10.1016/s0361-9230(01)00623-2", "pmid": "11750789", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02465", "slug": "massou-1997-frontal-5ht2a-receptors-studied", "title": "Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors.", "authors": "Massou, J M; Trichard, C; Attar-Levy, D; Feline, A; Corruble, E; Beaufils, B; Martinot, J L", "year": 1997, "journal": "Psychopharmacology, 133(1), 99-101", "doi": "10.1007/s002130050377", "pmid": "9335087", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02466", "slug": "depoortere-2021-marble-burying-in-nmri", "title": "Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists.", "authors": "Depoortere, Ronan; Bardin, Laurent; Auclair, Agnès L; Bruins Slot, Liesbeth A; Newman-Tancredi, Adrian", "year": 2021, "journal": "Pharmacology, 106(1-2), 114-118", "doi": "10.1159/000509729", "pmid": "32950991", "tags": [], "studyType": "", "evidenceStrength": "", "keyFinding": ""}, {"rthcId": "RTHM-02467", "slug": "albalawi-2025-dual-impact-of-ashwagandha", "title": "Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis.", "authors": "Albalawi, Ahmad Abdualrazag", "year": 2025, "journal": "Nutrition and health, 31(4), 1395-1408", "doi": "10.1177/02601060251363647", "pmid": "40746175", "tags": ["anxiety-stress"], "studyType": "systematic review and meta-analysis of randomized controlled trials", "evidenceStrength": "Meta-analytic evidence pooling 7 cortisol comparisons and 6 perceived-stress comparisons (n = 488) with moderate heterogeneity, moderate risk of bias, and no detected publication bias. Strong for the cortisol conclusion; the perceived-stress null is limited by a small pooled sample and wide confidence interval.", "keyFinding": "Ashwagandha significantly reduced cortisol by 1.16 ug/dL (95% CI -1.64 to -0.69, P < 0.001) across 7 randomized comparisons.\n\nAshwagandha did not significantly change perceived stress: SMD = -0.355 (95% CI -1.188 to 0.47, P = 0.40) across 6 randomized comparisons.\n\nThe confidence interval for perceived stress crosses zero and is wide, so this is an inconclusive null rather than proof that ashwagandha does nothing subjectively.\n\nThis dissociation between a moving biomarker and an unmoved self-report is the paper's central point, and it directly complicates the marketing claim that lowering cortisol makes people feel less stressed."}, {"rthcId": "RTHM-02468", "slug": "reishi-ashwagandha-perceived-stress-cdn-2025", "title": "A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effects of a Reishi Mushroom and Ashwagandha Supplement on Perceived Stress in Healthy Adults", "authors": "Gundermann, David; Ghatak, Somsuvra; Wilcox, Meredith L.; Maki, Kevin C.; Pauli, Emily K.", "year": 2025, "journal": "Current Developments in Nutrition, 9(Suppl 2), 106183", "doi": "10.1016/j.cdnut.2025.106183", "pmid": null, "tags": ["anxiety-stress", "reishi"], "studyType": "conference abstract of a virtual randomized, double-blind, placebo-controlled supplement trial", "evidenceStrength": "Large randomized sample but very low reporting depth. As a meeting abstract it is not a peer-reviewed full paper: methods, component doses, effect sizes, confidence intervals, secondary outcomes and adverse-event data are all unpublished. Treat as a preliminary signal awaiting full publication.", "keyFinding": "A supplement combining reishi (Ganoderma lucidum) fruiting-body extract with ashwagandha (Withania somnifera) extract improved perceived stress significantly more than placebo over 6 weeks in 499 healthy adults (P < 0.05).\n\nThis is the only randomized human comparison of a mushroom-plus-ashwagandha combination against placebo that has been reported to date.\n\nThe abstract reports no effect size, no confidence interval, no component doses, and no biological stress markers, so the magnitude and mechanism of the effect cannot be assessed.\n\nThe work was funded by MegaFood, which sells the reishi-and-ashwagandha product, and the author group includes company-affiliated and contract-research personnel."}]