Psilocybin Fundamentals
Explore mushroom research and guides on psilocybin fundamentals.
Psilocybin and the 5-HT2A Receptor Explained
Psilocybin targets the 5-HT2A receptor: dose-dependent occupancy up to ~72% in humans, the receptor-blockade proof, and why serotonin can't trigger the same neuroplasticity. Research-backed.
Psilocybin Receptor Binding Affinity: Why 5-HT2A Selectivity Matters
Psilocin achieves 60-70% 5-HT2A receptor occupancy at therapeutic doses. Why this selectivity matters: a 2023 Science paper changed the entire explanation.