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RTHM-02467 · 2025

A meta-analysis finding ashwagandha reliably lowers cortisol but does not significantly change how stressed people say they feel

Ashwagandha significantly reduced cortisol by 1.16 ug/dL (95% CI -1.64 to -0.69, P < 0.001) across 7 randomized comparisons. Ashwagandha did not significantly change perceived stress: SMD = -0.355 (95% CI -1.188 to 0.47, P = 0.40) across 6 randomized comparisons. The confidence interval for perceived stress crosses zero and is wide, so this is an inconclusive null rather than proof that ashwagandha does nothing subjectively. This dissociation between a moving biomarker and an unmoved self-report is the paper's central point, and it directly complicates the marketing claim that lowering cortisol makes people feel less stressed.

Albalawi, Ahmad Abdualrazag · Systematic Review And Meta Analysis Of Randomized Controlled Trials

RTHM-00815 · 2023

Mushroom consumption and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies.

Ba, Djibril M; Ssentongo, Paddy; Pelucchi, Claudio; Negri, Eva; Palli, Domenico; Ferraroni, Monica; Zhang, Zuo-Feng; Yu, Guo-Pei; Tsugane, Shoichiro; Hidaka, Akihisa; Hamada, Gerson Shigueaki; Zaridze, David; Maximovich, Dmitry; Obón-Santacana, Mireia; Álvarez-Álvarez, Laura; Vioque, Jesus; Garcia de la Hera, Manoli; López-Carrillo, Lizbeth; López-Cervantes, Malaquias; Mu, Lina; Lagiou, Areti; Lagiou, Pagona; Boffetta, Paolo; Camargo, Maria Constanza; Curado, Maria Paula; Lunet, Nuno; La Vecchia, Carlo; Muscat, Joshua ·