Cordycepin Research

Cordycepin (3'-Deoxyadenosine): The Multi-Target Mushroom Drug

Cordycepin is an adenosine analogue from Cordyceps militaris that hits adenosine receptors, NLRP3, the TIGAR/SIRT1/PGC-1α axis, and PI3K/AKT/mTOR. A 791-paper systematic review puts the median cell-study IC50 at 135 µM — and rapid deamination blocks oral delivery. Here's the mechanism evidence.