Psilocybin & Depression
Explore mushroom research and guides on psilocybin & depression.
How Long Does Psilocybin Last for Depression? The Evidence
Psilocybin for depression: response appears within days, peaks at 4 weeks, and lasts 12+ months in many trial participants. What the duration evidence shows.
Psilocybin and Default Mode Network Changes in Depression
Psilocybin suppresses the default mode network during dosing and reorganizes it afterward. A 2023 systematic review links both phases to depression recovery.
Psilocybin for Depression: Clinical Trial Results
The complete evidence: what the largest psilocybin trials found for depression, from Phase 2 RCTs to the first Phase 3 results, with null results included.
Psilocybin for Major Depression: The Clinical Evidence
Psilocybin for major depression: the complete evidence from Phase 2 RCTs, a 2025 dose-response analysis, the Phase 3 program, and the EPISODE null result.
Psilocybin Therapy for Depression: Who Responds Best?
Who responds best to psilocybin therapy for depression? New research identifies brain biomarkers, session experience, and SSRI use as outcome predictors.