Psilocybin Neuroscience
Explore mushroom research and guides on psilocybin neuroscience.
5-HT2A Receptor Density and Psilocybin Response
How baseline 5-HT2A serotonin receptor density in the brain predicts individual psilocybin response, from PET imaging data to receptor downregulation.
Psilocybin and Sigma-1 Receptors: Emerging Research
Does psilocybin bind sigma-1 receptors? Its affinity is weak; DMT is the primary tryptamine. Here's what sigma-1 neuroprotection does and why it matters.
Thalamic Gating and Psilocybin: Sensory Flooding Explained
How psilocybin breaks thalamic gating, the brain's sensory filter, and why specific thalamic nuclei produce sensory flooding in psychedelic states.
The Claustrum and Psilocybin: A New Theory of Consciousness
Psilocybin reduces claustrum activity 15-30% and correlates with mystical experience. The 2025 Nature Comms paper pinpoints the receptor mechanism.