Psilocybin & the Default Mode Network
Explore mushroom research and guides on psilocybin & the default mode network.
Default Mode Network and Depression: Why Psilocybin's DMN Effect Matters
Psilocybin targets the hyperactive default mode network that drives depression. Here's the fMRI evidence on what it does and why 71% of patients responded.
Psilocybin and the Default Mode Network: How It Quiets the Ego
Psilocybin disrupts the default mode network, causing ego dissolution. The 2024 Nature study shows how, why it lasts, and what it means for depression.
Psilocybin Ego Dissolution: How Your Brain Changes
Psilocybin ego dissolution disrupts three brain networks simultaneously. New research shows how deep those brain changes go predicts recovery four months later.
Psilocybin, DMN Disruption, and Mystical Experience
Psilocybin's DMN disruption correlates with mystical experience. The depth of that state during the session statistically predicts antidepressant outcomes.
What Happens When the DMN Goes Offline on Psilocybin
When psilocybin disrupts the default mode network, it desynchronizes rather than suppresses. Here is what breaks, in order, and what stays changed afterward.