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Research library — page 19

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RTHM-02281 · 2022

β-Glucan Combined With PD-1/PD-L1 Checkpoint Blockade for Immunotherapy in Patients With Advanced Cancer.

In a tumor mouse model, whole glucan particle (WGP) beta-glucan combined with PD-1/PD-L1-blocking antibodies increased immune cell recruitment, improved the balance between T-cell activation and immune tolerance, and delayed tumor progression compared with checkpoint blockade alone.

Wang, Meng; Bai, Yang; Pei, Jinjun; Li, Dongjie; Pu, Xiaolan; Zhu, Wenyu; Xia, Lei; Qi, Chunjian; Jiang, Hua; Ning, Yeshan ·

RTHM-02335 · 2025

Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial.

Wießner, Isabel; Falchi-Carvalho, Marcelo; Laborde, Sophie; Barros, Handersson; Bolcont, Raynara; Ruschi Silva, Sérgio; Pantrigo, Érica; Medina, Melanie; Arichelle, Flávia; Almeida, Raissa; Aires, Rosana; Nunes Ferreira, Luis Fernando; Dantas Corrêa, Luísa; Da Costa Bezerra, Romária Bárbara; Thie, Kaike; Silva-Costa, Natan; de Araújo Costa Neto, Luiz Antonio; Jales Lima de Queiroz, Marcos Vinícius; Galvão-Coelho, Nicole; Araujo, Draulio; Palhano-Fontes, Fernanda ·

RTHM-02209 · 2025

What This 2025 Chaga Supplement Authentication Study Actually Found

Authentic chaga canker maintained a low-alpha, moderate-beta glucan pattern, while myceliated grain products flipped to high alpha-glucans that tracked cereal starch content. Lugol staining and alpha-amylase digestion showed that the purple signal in myceliated grain products was starch-driven rather than a marker of authentic chaga chemistry. Melanin-rich dark canker materials separated cleanly from pale myceliated grain products on alkaline extraction and UV-Vis absorbance. Authentic canker contained inotodiol, trametenolic acid, lanosterol, osmundacetone, and syringic acid, whereas the myceliated grain products did not reproduce that marker set. NMR and LC-QToF-MS showed that the canker extract stayed close to authentic chaga canker and that the myceliated grain products still looked chemically like their cereal substrates. This is a strong product-authentication paper, not a health-effects paper. Across glucans, starch, melanin, triterpenoids, NMR, and LC-MS, authentic chaga canker and the one retail canker extract grouped together while the myceliated grain products mostly tracked their cereal substrates instead.

Windsor, Coleton; Kreynes, Anna E; Chilton, Jeff S; Chioffi, William A; Krishnamurthy, Arun; Ishii, Melissa · Comparative Supplement Authentication Study