Psilocybin & Addiction
Explore mushroom research and guides on psilocybin & addiction.
How Psilocybin Helps Stop Drinking: Brain Mechanisms
Psilocybin reduces alcohol cravings via mGluR2 receptor normalization, nucleus accumbens activation, and DMN disruption. Here's what the mechanistic research shows.
Neuroplasticity and Addiction: How Psilocybin Opens a Window
Psilocybin triggers rapid synaptic growth and cortical rewiring that reverses addiction-induced brain atrophy. Here's the neuroplasticity window explained.
One Psilocybin Session and Reduced Drinking: The Data
One psilocybin session reduced heavy drinking by 37.5 percentage points in a 2025 study. The data, the counterevidence, and what the difference means.
Psilocybin Alcohol Use Disorder: Long-Term Results
Psilocybin alcohol use disorder research: 48% abstinence at 8 months from the 2022 JAMA RCT, plus 2025 trial results and what sustained sobriety data tells us.
Psilocybin Craving Reduction: How It Works in the Brain
Psilocybin reduces cravings through four distinct brain mechanisms. We cover the molecular science, fMRI evidence, and what the 2025 phase 2 trial showed.
Psilocybin and Default Mode Network Disruption in Addiction
Psilocybin disrupts the default mode network 3× more powerfully than Ritalin, with key changes lasting up to 3 weeks. What this means for addiction treatment.
Can Psilocybin Help You Quit Weed? Here's the Honest Answer
Psilocybin shows strong results in alcohol and tobacco addiction trials. No completed trial tests it for cannabis. Here's what the evidence shows as of 2025.
Psilocybin for Addiction: Why It Works Across Substances
Psilocybin shows results for tobacco, alcohol, and opioid addiction. The research across substances, and the shared brain mechanism that explains why one compound works.
Psilocybin for Alcohol Addiction: The NYU Clinical Trial Results
Two psilocybin sessions cut heavy drinking days 83% vs 51% for placebo in the JAMA Psychiatry RCT. The trial data, 2025 follow-ups, and what the evidence means.
Why One Psilocybin Session Can Disrupt Addiction
Habits live in specific brain circuits that become automatic over time. Research shows how a single psilocybin session disrupts those circuits for weeks.
How Psilocybin Treats Addiction: The Neuroscience
How psilocybin changes the brain to treat addiction. Five mechanisms: from 5-HT2A receptor binding to structural neuroplasticity to weeks of DMN disruption.